Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Raymond Toles"'
Autor:
Martin Hauer-Jensen, Steven R. Mog, Shilpa Kulkarni, Merriline M. Satyamitra, Raymond Toles, Kevin P. Hieber, Tzu Cheg Kao, Sanchita P. Ghosh, Lyudmila Romanyukha, K. Sree Kumar, Kristen Gambles
Publikováno v:
Radiation Research. 173:738-747
We analyzed the radioprotective effects of gamma-tocotrienol (GT3) on hematopoietic stem cells (HSCs) and progenitor cells (HPCs) in sublethally irradiated mice. Flow cytometry analysis indicated that radiation depleted HPCs (c-Kit(+), Lin(-)) to 40%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e65c2eee08627881164275489a9d535
https://doi.org/10.1667/rr1824.1
https://doi.org/10.1667/rr1824.1
Autor:
Lyudmila Romanyukha, Kevin P. Hieber, Tzu Cheg Kao, Raymond Toles, K. Sree Kumar, Shilpa Kulkarni, Martin Hauer-Jensen, Sanchita P. Ghosh
Publikováno v:
International Journal of Radiation Biology. 85:598-606
To assess the radioprotective potential of gamma-tocotrienol.To optimise its dose and time regimen, gamma-tocotrienol (GT3) was injected subcutaneously (SC) at different doses into male CD2F1 mice [LD(50/30) (lethal radiation dose that results in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ff24dfe15c97f96319c76c794da119
https://doi.org/10.1080/09553000902985128
https://doi.org/10.1080/09553000902985128
Autor:
Andreas M. Papas, Nannette C Parra, Kevin P. Hieber, Thomas M. Seed, Mythili Raghavan, K. Sree Kumar, Venkataraman Srinivasan, Vijay K. Singh, Steven R. Mog, Gyorgy Petrovics, Shiv Srivastava, Patience Karikari, Raymond Toles, Christine A Ege, Annette Hildabrand
Publikováno v:
Life Sciences. 78:2099-2104
Gamma-tocotrienol (GT) is a member of the vitamin E family. Our preliminary studies indicated that it protected mice from lethal irradiation, so we hypothesized that GT might be a radiation sensitizing agent for tumors. To test this, we induced prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d0fb4e5e53d0ae2e1ef97964289a89
https://doi.org/10.1016/j.lfs.2005.12.005
https://doi.org/10.1016/j.lfs.2005.12.005
Autor:
Raymond Toles, William E. Jackson, K. Sree Kumar, Venkataraman Srinivasan, Venita Miner, Thomas M. Seed
Publikováno v:
Journal of Radiation Research. 43:361-370
There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb5fc3b7de3b758019e6cc2b8a118e7
https://doi.org/10.1269/jrr.43.361
https://doi.org/10.1269/jrr.43.361
Publikováno v:
Military medicine. 167
Low-level radiation injury is dependent on the radiation dose and dose rate. The major military use of any potential radioprotectant is to prevent the short-term effects of lethality and the long-term effects of cancer and other pathologies from radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7135e94534b0ec7d883394e91252a27
https://pubmed.ncbi.nlm.nih.gov/11873518
https://pubmed.ncbi.nlm.nih.gov/11873518
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 197(4)
Bile acids are one of the components of the gastric contents capable of disrupting the mucosal barrier to diffusion. The mechanism by which bile acids can damage the gastric epithelium is not completely understood. Several studies have emphasized muc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df78d6e171f5fbc4fc86f7c351145d1
https://pubmed.ncbi.nlm.nih.gov/1871149
https://pubmed.ncbi.nlm.nih.gov/1871149
Publikováno v:
Pharmacology. 30:215-224
In rabbit gastric cells the new H2-antagonists, BL-6341A, SK&F 93479 and L-643,441 were highly potent inhibitors of the H2-receptor mediated action of histamine as monitored by 14C-aminopyrine uptake and cyclic AMP formation. BL-6341A and SK&F 93479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b8aeff7fde94190cca349562130646
https://doi.org/10.1159/000138071
https://doi.org/10.1159/000138071
Publikováno v:
Biochimica et biophysica acta. 720(2)
In dispersed mucosal cells prepared from rabbit and guinea pig stomach, the secretion of intrinsic factor was constant (0.3–0.4%/min) for at least 30 min incubation at 37°C. Histamine or isobutyl methylxanthine increased cyclic AMP and intrinsic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39259ce9f61395333036d8a57e67c42a
https://pubmed.ncbi.nlm.nih.gov/6177350
https://pubmed.ncbi.nlm.nih.gov/6177350
Autor:
Venita Miner, Ckatherine Farrell, Michael Stewart, Jason Deen, CM Chang, Edward Hilyard, William E. Jackson, James Pendergrass, Alexandra C. Miller, Mark H. Whitnall, Thomas M. Seed, Venkataraman Srinivasan, Thomas B. Elliott, Vijay K. Singh, Raymond Toles, Cyndi Inal, Sree Kumar, Michael R. Landauer, James Benjack, Dimitry M. Danilenko, Martin Gehlhaus, Vilmar Villa
Publikováno v:
Scopus-Elsevier
New strategies for the prevention of radiation injuries are currently being explored with the ultimate aim of developing globally radioprotective, nontoxic pharmacologics. The prophylactic treatments under review encompass such diverse pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9397a99b79bab47c0d247d20dc5413f
http://www.scopus.com/inward/record.url?eid=2-s2.0-0038678495&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0038678495&partnerID=MN8TOARS
