Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting

Autor: Arthur Hsu, Graham R. Taylor, Renata Marquis, Andrew W. Roberts, Andrew Fellowes, Stephen B. Fox, Ben Tran, Ken Doig, Belinda Lee, Paul A. James, Anne Hamilton, Jayesh Desai, Raymond Snyder, Jennifer Mooi, Paul G Ekert, Grant A. McArthur, Dishan Herath, Paul Waring, Clara Gaff

Publikováno v: Internal Medicine Journal. 48:786-794

BACKGROUND: Technology has progressed from single gene panel to large-scale genomic sequencing. This is raising expectations from clinicians and patients alike. The utility and performance of this technology in a clinical setting needs to be evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48335ce3a1e6d4713600d3c3085a2fb1
https://doi.org/10.1111/imj.13806

Mapping the EORTC-QLQ-C30 to the EQ-5D-3L: An assessment of existing and newly developed algorithms

Autor: Fionn Woodcock, Brett Doble, Stephen B. Fox, Ian Collins, Theresa Hayes, Madhu Singh, Gary Richardson, Lara Lipton, So-Young Moon, Mark Lucas, Andrew Fellowes, Huiling Xu, Heather Thorne, John J. McNeil, Paula Lorgelly, David M. Thomas, Paul A. James, Tomas John, Gail Risbridger, Gavin Wright, Raymond Snyder

Publikováno v: Medical Decision Making. 38(8)

Objectives: To assess the external validity of mapping algorithms for predicting EQ-5D-3L utility values from EORTC QLQ-C30 responses not previously validated and to assess whether statistical models not previously applied are better suited for mappi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30f46207947244ff0f040698d6b5bc2
http://ora.ox.ac.uk/objects/uuid:

Differential efficacy of three cycles of CMF followed by tamoxifen in patients with ER-positive and ER-negative tumors: Long-term follow up on IBCSG Trial IX

Autor: A. Goldhirsch, Richard D. Gelber, S. Aebi, Edda Simoncini, Diana Crivellari, Barry A. Gusterson, Danielle Braun, Per Karlsson, Zhuoxin Sun, Meredith M. Regan, Manuela Rabaglio, Karen N. Price, J. Lindtner, M. Castiglione-Gertsch, Alan S. Coates, Raymond Snyder, Giuseppe Viale

Publikováno v: Aebi, S; Sun, Z; Braun, D; Price, K N; Castiglione-Gertsch, M; Rabaglio, M; Gelber, R D; Crivellari, D; Lindtner, J; Snyder, R; Karlsson, P; Simoncini, E; Gusterson, B A; Viale, G; Regan, M M; Coates, A S; Goldhirsch, A (2011). Differential efficacy of three cycles of CMF followed by tamoxifen in patients with ER-positive and ER-negative tumors: long-term follow up on IBCSG Trial IX. Annals of oncology, 22(9), pp. 1981-7. Oxford: Oxford University Press 10.1093/annonc/mdq754

Background: The benefit of adjuvant chemotherapy in postmenopausal patients with estrogen receptor (ER)-positive lymph node-negative breast cancer is being reassessed. Patients and methods: After stratification by ER status, 1669 postmenopausal patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf82f7af05b736383c5103e291b5c758
http://doc.rero.ch/record/304488/files/mdq754.pdf

A retrospective cohort study of metastatic colorectal cancer patients treated with oxaliplatin-based chemotherapy, with an exploratory analysis of changing serum carcinoembryonic antigen levels

Autor: Say Liang Ng, Genni M Newnham, W. I. Burns, Sue-Anne McLachlan, Raymond Snyder, Anthony Dowling, Danny Liew

Publikováno v: Asia-Pacific Journal of Clinical Oncology. 8:172-179

Aim: To examine the relationship between changes in serum carcinoembryonic antigen (CEA) levels and survival during oxaliplatin-based chemotherapy for metastatic colorectal cancer (mCRC). Methods: A retrospective review of 142 patients with mCRC who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0c5a5113e5d548f7833e279337a400
https://doi.org/10.1111/j.1743-7563.2011.01486.x

Abstract P5-13-01: Patterns of Breast Cancer Relapse According to Breast Cancer Subtypes in Lymph Node-Negative Breast Cancer — Results from International Breast Cancer Study Group Trials VIII and IX

Autor: R. D. Gelber, Zhuoxin Sun, A. Goldhirsch, Diana Crivellari, Fatima Cardoso, Raymond Snyder, Meredith M. Regan, Otto Metzger, A. S. Coates, G. Viale

Publikováno v: Cancer Research. 70:P5-13

Background: To explore the patterns of breast cancer (BC) relapse according to BC subtypes in a lower risk (lymph node (LN)-negative) population we classified pts from two trials according to a molecular classification using IHC surrogates. IBCSG Tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46469b044a769a03fd3e993a2685f13e
https://doi.org/10.1158/0008-5472.sabcs10-p5-13-01