Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Raymond S. Yeung"'
Autor:
Sophia M. Lauer, Mitchell H. Omar, Martin G. Golkowski, Heidi L. Kenerson, Kyung-Soon Lee, Bryan C. Pascual, Huat C. Lim, Katherine Forbush, F. Donelson Smith, John D. Gordan, Shao-En Ong, Raymond S. Yeung, John D. Scott
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113678- (2024)
Summary: The DNAJ-PKAc fusion kinase is a defining feature of fibrolamellar carcinoma (FLC). FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor. By combining proximity pr
Externí odkaz:
https://doaj.org/article/0017dacb347145b2ba79f18c4ba57c47
Autor:
Yu Ling Huang, Lindsay K. Dickerson, Heidi Kenerson, Xiuyun Jiang, Venu Pillarisetty, Qiang Tian, Leroy Hood, Taranjit S. Gujral, Raymond S. Yeung
Publikováno v:
BME Frontiers, Vol 4 (2023)
In the era of personalized oncology, there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual cancers. An ideal assay will serve as a diagnostic companion to inform the oncologist of the va
Externí odkaz:
https://doaj.org/article/43b2d1ba3f9349ed94f8b46945481809
Autor:
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan
Publikováno v:
eLife, Vol 12 (2023)
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signal
Externí odkaz:
https://doaj.org/article/05fc37cffa674796bf7877b4353fc32a
Autor:
Lindsay C. Czuba, Xia Wu, Weize Huang, Nicole Hollingshead, Jessica B. Roberto, Heidi L. Kenerson, Raymond S. Yeung, Ian N. Crispe, Nina Isoherranen
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 976-989 (2021)
Abstract All‐trans‐retinoic acid (atRA), the active metabolite of vitamin A, has antifibrogenic properties in vitro and in animal models. Liver vitamin A homeostasis is maintained by cell‐specific enzymatic activities including storage in hepat
Externí odkaz:
https://doaj.org/article/34b049063fdf462bbd6d0416bfd3488f
Autor:
Kevin P. Labadie, Andrew D. Ludwig, Adrienne L. Lehnert, Donald K. Hamlin, Aimee L. Kenoyer, Kevin M. Sullivan, Sara K. Daniel, Tara N. Mihailovic, Jonathan G. Sham, Johnnie J. Orozco, Raymond S. Yeung, Delphine L. Chen, D. Scott Wilbur, Robert S. Miyaoka, James O. Park
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Glypican-3 (GPC3) is a tumor associated antigen expressed by hepatocellular carcinoma (HCC) cells. This preclinical study evaluated the efficacy of a theranostic platform using a GPC3-targeting antibody αGPC3 conjugated to zirconium-89 (89Z
Externí odkaz:
https://doaj.org/article/ddea22e7449b4b418c2f02ca24983fd2
Autor:
Xia Wu, Jessica B. Roberto, Allison Knupp, Alexander L. Greninger, Camtu D. Truong, Nicole Hollingshead, Heidi L. Kenerson, Marianne Tuefferd, Antony Chen, David M. Koelle, Helen Horton, Keith R. Jerome, Stephen J. Polyak, Raymond S. Yeung, Ian N. Crispe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Precision-cut human liver slice cultures (PCLS) have become an important alternative immunological platform in preclinical testing. To further evaluate the capacity of PCLS, we investigated the innate immune response to TLR3 agonist (poly-I:C) and TL
Externí odkaz:
https://doaj.org/article/75336c7dd31743c385e9d9eee84beec0
Autor:
Heidi L. Kenerson, Kevin M. Sullivan, Kevin P. Labadie, Venu G. Pillarisetty, Raymond S. Yeung
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100574- (2021)
Summary: The impact of systemic therapy on the tumor microenvironment has been difficult to study in human solid tumors. Our protocol describes steps for establishing slice cultures to investigate response to chemotherapies, immunotherapies, or adopt
Externí odkaz:
https://doaj.org/article/1fef7fe50ad6476a9f8d210e0453e5c6
Autor:
Minjun C. Apodaca, Amy E. Wright, Angela M. Riggins, William P. Harris, Raymond S. Yeung, Lei Yu, Chihiro Morishima
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background Myeloid-derived suppressor cells (MDSC) have been found to play an important role in limiting immune responses in cancer. Higher circulating MDSC levels have been associated with greater tumor burden, poorer response to immunother
Externí odkaz:
https://doaj.org/article/f6bc21757aba4630b488698793a27e25
Autor:
Timothy A. Dinh, Mark L. Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E. Turnham, Seona Lee, Edward R. Kastenhuber, Eliane Wauthier, Cynthia D. Guy, Raymond S. Yeung, Scott W. Lowe, Lola M. Reid, John D. Scott, Anna M. Diehl, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 803-817 (2019)
Background & Aims: Fibrolamellar carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. It is characterized by a heterozygous approximately 400-kb deletion on chromosome 19 that results in a unique fusion between
Externí odkaz:
https://doaj.org/article/7c0b575b397444a8aec84eb5e9313d8a
Autor:
Sara B. Keller, Dingjie Suo, Yak-Nam Wang, Heidi Kenerson, Raymond S. Yeung, Michalakis A. Averkiou
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Despite advances in interventional procedures and chemotherapeutic drug development, hepatocellular carcinoma (HCC) is still the fourth leading cause of cancer-related deaths worldwide with a
Externí odkaz:
https://doaj.org/article/a7125e09c696441b92317d5365a97a5d