Výsledky vyhledávání - "Raymond S. H. Yang"

Akademický článek

An In Silico Approach for Evaluating a Fraction-Based, Risk Assessment Method for Total Petroleum Hydrocarbon Mixtures

Autor: Nina Ching Y. Wang, Glenn E. Rice, Linda K. Teuschler, Joan Colman, Raymond S. H. Yang

Publikováno v: Journal of Toxicology, Vol 2012 (2012)

Both the Massachusetts Department of Environmental Protection (MADEP) and the Total Petroleum Hydrocarbon Criteria Working Group (TPHCWG) developed fraction-based approaches for assessing human health risks posed by total petroleum hydrocarbon (TPH)

Externí odkaz: https://doaj.org/article/18e00ce8b6674e1fb9792664e5f2bde4

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Abstract 5696: Genetic reprogramming of TAMs by engineered exosomes results in potent single agent anti-tumor activity

Autor: Dalia Burzyn, William K. Dahlberg, Eric Zhang, Sylvie Maubant, Sriram Sathyanarayanan, Kyriakos D. Economides, Scott Estes, Olivier Duchamp, Tong Zi, Katherin Kirwin, Charan Leng, Timothy Soos, Raymond S. H. Yang, Sushrut Kamerkar, Olga Burenkova, Su Chul Jang

Publikováno v: Cancer Research. 80:5696-5696

Background: Tumor-associated macrophages (TAMs) are potent drivers of an immunosuppressive tumor microenvironment by reducing T cell recruitment and activation, promoting resistance to immune checkpoint inhibition. Experimental therapies blocking mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de5ec91b66e92ec0ada16623393e147a
https://doi.org/10.1158/1538-7445.am2020-5696

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Toxicology and Risk Assessment of Chemical Mixtures and Multiple Stressors

Autor: Raymond S. H. Yang

This article is a continuation and update from the previous two editions which were published, respectively, in 1997 and 2010. Since the publication of the first book on Toxicology of Chemical Mixtures in 1994 ( Yang, 1994a ), we witnessed, with grat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::408d08f874654625f267740584909794
https://doi.org/10.1016/b978-0-12-801238-3.64942-5

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A physiologically-based pharmacokinetic model of methotrexate incorporating hepatic excretion via multidrug-resistance-associated protein 2 (Mrp2) in mice, rats, dogs, and humans

Autor: Yasong Lu, Raymond S. H. Yang, Ornrat Lohitnavy, Manupat Lohitnavy

Publikováno v: EMBC

An updated physiologically-based pharmacokinetic (PBPK) model of methotrexate (MTX) was built based on an earlier model developed by Bischoff et al. (1971). MTX has been known to be a substrate of multidrug-resistance-associated protein 2 (Mrp2). A t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7200a434c369c6e9e098347b9012fa2b
https://pubmed.ncbi.nlm.nih.gov/29060462

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Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples

Autor: Raymond S. H. Yang, Jeffrey W. Fisher, Jim E. Riviere, Shiqiang Jin, Chunla He, Majid Jaberi-Douraki, Zhoumeng Lin

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 158(1)

Many physiologically based pharmacokinetic (PBPK) models for environmental chemicals, drugs, and nanomaterials have been developed to aid risk and safety assessments using acslX. However, acslX has been rendered sunset since November 2015. Alternativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4408bdaa129ef3883e6dc089b0fbfec
https://pubmed.ncbi.nlm.nih.gov/28402537

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Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

Autor: Paul S. Price, Rosemary T Zaleski, Moiz Mumtaz, Kevin M. Crofton, Susan P. Felter, Michelle R. Embry, Alan R. Boobis, Robert A. Budinsky, David Kopp, Raymond S. H. Yang, Shanna Collie, Linda K. Teuschler, Keith R. Solomon, Gary Mihlan, Richard C. Hertzberg

Publikováno v: Critical Reviews in Toxicology. 41:369-383

There is increasing interest in the use of tiered approaches in risk assessment of mixtures or co-exposures to chemicals for prioritization. One possible screening-level risk assessment approach is the threshold of toxicological concern (TTC). To dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b494e8f68025624503e62c4a53efa6a2
https://doi.org/10.3109/10408444.2010.543655

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Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results

Autor: Thomas E. McKone, Dennis P.H. Hsieh, Michael D. Sohn, Laurel E. Redding, Shu-Li Wang, Raymond S. H. Yang, Jein-Wen Chen

Publikováno v: Environmental Health Perspectives

Background One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these chemicals in breast milk. Objectives We developed a physiologically based pharmacokinetic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6b46601781a657c28803fccfeafddd
https://doi.org/10.1289/ehp.11519

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