Zobrazeno 1 - 10
of 1 034
pro vyhledávání: '"Raymond S, Hurst"'
Autor:
Jean‐François Blain, Angela Y.P. Chen, Morgan A. Brand, James C. Lanter, Christopher J. Holler, Jerusha K. Brendel, Gerhard Koenig, Duane A. Burnett, Raymond S. Hurst
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9044e175ad98fcfd65aa7cfa4c8a217f
https://doi.org/10.1002/alz.061924
https://doi.org/10.1002/alz.061924
Autor:
Xiaowen Peng, James C. Lanter, Angela Y.-P. Chen, Morgan A. Brand, Mary K. Wozniak, Steven Hoekman, Ondřej Longin, Hendrik Regeling, Wim Zonneveld, Roel P. L. Bell, Gerhard Koenig, Raymond S. Hurst, Jean-François Blain, Duane A. Burnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 80
Phenotypic screening of an annotated small molecule library and initial SAR studies identified compound 2 as a robust enhancer of progranulin secretion. Detailed SAR development on conformationally restricted carbamate isosteres led to the identifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3166d43ab089bab031ab58c991137363
https://pubmed.ncbi.nlm.nih.gov/36368496
https://pubmed.ncbi.nlm.nih.gov/36368496
Autor:
Mihály Hajós, Zhiming Tu, Ting Chen, Matthew Townsend, Milan Stoiljkovic, Dorothy G. Flood, Hilliary Hodgdon, Daniel Bertrand, Liza Leventhal, Dávid Nagy, Gerhard Koenig, Angela Chen, Raymond S. Hurst, Timothy M. Piser, Cuyue Tang, Rachelle Driscoll
Publikováno v:
Biochemical Pharmacology. 97:576-589
Pharmacological activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) may improve cognition in schizophrenia and Alzheimer's disease. The present studies describe an integrated pharmacological analysis of the effects of FRM-17874, an analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945e50f33ae5780980b6ee6800eca3ee
https://doi.org/10.1016/j.bcp.2015.07.006
https://doi.org/10.1016/j.bcp.2015.07.006
Autor:
Raymond S. Hurst, Hans Rollema
Publikováno v:
Psychopharmacology. 235(9)
Two mechanisms underlie smoking cessation efficacies of α4β2* nicotinic acetylcholine receptor (nAChR) agonists: a “nicotine-like” agonist activity reduces craving by substituting for nicotine during a quit attempt, and a “nicotine-blocking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fbc9a8e9d239b003dafce071b1d33c
https://pubmed.ncbi.nlm.nih.gov/29980822
https://pubmed.ncbi.nlm.nih.gov/29980822
Autor:
Raymond S. Hurst, Mihály Hajós, Dennis J. Hoover, William E. Hoffmann, Nandini Chaturbhai Patel, Christopher L. Shaffer, Xinjun J. Hou, Christopher J. O’Donnell, Dina McGinnis, Jayvardhan Pandit, Eric S. Marr, Randall James Gallaschun, Dianne K. Bryce, John T. Lazzaro, Longfei Xie, Jacob Bradley Schwarz, Fliri Anton F J, Justin L Gazard, Ashley N. Hanks, Renato J. Scialis
Publikováno v:
Journal of Medicinal Chemistry. 56:9180-9191
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56e4065349b607cc298e139b742e784
https://doi.org/10.1021/jm401274b
https://doi.org/10.1021/jm401274b
Publikováno v:
Pharmacology & Therapeutics. 137:22-54
Substantial progress in the identification of genes encoding for a large number of proteins responsible for various aspects of neurotransmitter release, postsynaptic detection and downstream signaling, has advanced our understanding of the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8059cffbedd1054350dfe63055f4e00c
https://doi.org/10.1016/j.pharmthera.2012.08.012
https://doi.org/10.1016/j.pharmthera.2012.08.012
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(12)
Activation of α7 nAChRs has been shown to improve performance in a variety of nonclinical assays of cognitive function. The role of α7 nAChRs in cognitive processes is likely related to their role in modulating synaptic transmission and plasticity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91d638e2595a8417f54be958a15d374
https://pubmed.ncbi.nlm.nih.gov/27866776
https://pubmed.ncbi.nlm.nih.gov/27866776
Autor:
Laura McDowell, Sarah M. Osgood, Shari L. DeNinno, Hans Rollema, Chris L. Shaffer, Robert J. Mather, Brenda R. Ellerbrock, Jotham Wadsworth Coe, Theresa Tritto, Rouba Kozak, Jen Sadlier, Raymond S. Hurst, Weldon Horner, Roxanne R Gorczyca, Mary C. MacDougall, F. David Tingley, Mark J. Majchrzak, Lei Zhang, Alka Shrikhande, John A. Lowe, Scot Richard Mente, Karen M. Ward, David E. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4749-4752
We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of α3- and α6-containing nicotinic receptors. In particular, compound 17a from this series is a potent α3β4 and α6/4β4 receptor agonist in terms of bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c382b229004850d41226ee3e512105a
https://doi.org/10.1016/j.bmcl.2010.06.142
https://doi.org/10.1016/j.bmcl.2010.06.142
Autor:
Steve L. Stice, Raymond S. Hurst, John E. Hambor, Jacob Bradley Schwarz, Robert J. Mather, John D. McNeish, Laura E. Zawadzke, Justin L Gazard, David W. Machacek, Robert A. Volkmann, Christopher J. O’Donnell, John T. Lazzaro, Marsha L. Roach, Laura Weibley
Publikováno v:
Journal of Biological Chemistry. 285:17209-17217
Stem cell biology offers advantages to investigators seeking to identify new therapeutic molecules. Specifically, stem cells are genetically stable, scalable for molecular screening, and function in cellular assays for drug efficacy and safety. A key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7ae6eb34a5c085f4005a3a4646a0a5
https://doi.org/10.1074/jbc.m109.098814
https://doi.org/10.1074/jbc.m109.098814
Autor:
Raymond S. Hurst, Bruce N. Rogers, Mihály Hajós, Rodney R. Walters, Donn G. Wishka, Brian A. Staton, David W. Piotrowski, Brad A. Acker, Kai S. Li, Michael Krause, Vincent E. Groppi, William E. Hoffmann, Daniel P. Walker, Barbara A. Olson, Laura Fitzgerald, E. Jon Jacobsen, Thomas J. Raub, Mark L. Wolfe, Bruce A. Thornburgh, Paula M. Tinholt, Steven Charles Reitz, Jason K. Myers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3611-3615
A novel α7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (3a, PHA-709829), has been identified for the potential treatment of cognitive deficits in schizophrenia. The compound shows potent and selective α7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4401b56d4c1dc535fb66dd987f2e99f3
https://doi.org/10.1016/j.bmcl.2008.04.070
https://doi.org/10.1016/j.bmcl.2008.04.070