Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Raymond R Tice"'
Autor:
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177902 (2017)
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dep
Externí odkaz:
https://doaj.org/article/8b650d38ea7240319ec39f2d30d45c86
Autor:
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181291 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0177902.].
Externí odkaz:
https://doaj.org/article/789e569b41a9423faff626bf9ef46955
Autor:
B Alex Merrick, Dhiral P Phadke, Scott S Auerbach, Deepak Mav, Suzy M Stiegelmeyer, Ruchir R Shah, Raymond R Tice
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61768 (2013)
Deep sequencing was used to investigate the subchronic effects of 1 ppm aflatoxin B1 (AFB1), a potent hepatocarcinogen, on the male rat liver transcriptome prior to onset of histopathological lesions or tumors. We hypothesized RNA-Seq would reveal mo
Externí odkaz:
https://doaj.org/article/a3b59a1659ee46fb996fa3a880f22e55
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Autor:
Sara A. Grimm, Takashi Shimbo, Motoki Takaku, James W. Thomas, Scott Auerbach, Brian D. Bennett, John R. Bucher, Adam B. Burkholder, Frank Day, Ying Du, Christopher G. Duncan, John E. French, Julie F. Foley, Jianying Li, B. Alex Merrick, Raymond R. Tice, Tianyuan Wang, Xiaojiang Xu, NISC Comparative Sequencing Program, Pierre R. Bushel, David C. Fargo, James C. Mullikin, Paul A. Wade
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across g
Externí odkaz:
https://doaj.org/article/f487b8a5e96d4b4596531537eeed2656
Autor:
Candice, Johnson, Lennart T, Anger, Romualdo, Benigni, David, Bower, Frank, Bringezu, Kevin M, Crofton, Mark T D, Cronin, Kevin P, Cross, Magdalena, Dettwiler, Markus, Frericks, Fjodor, Melnikov, Scott, Miller, David W, Roberts, Diana, Suarez-Rodriguez, Alessandra, Roncaglioni, Elena, Lo Piparo, Raymond R, Tice, Craig, Zwickl, Glenn J, Myatt
Publikováno v:
Comput Toxicol
Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing reliability and relevance is well d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c0d7cdba4ae97555f59d6dc5262e2a5
https://pubmed.ncbi.nlm.nih.gov/35368849
https://pubmed.ncbi.nlm.nih.gov/35368849
Autor:
Emilio Benfenati, Elisabet Berggren, Ellen Fritsche, Thomas Hartung, William Slikker Jr, Horst Spielmann, Emanuela Testai, Raymond R. Tice, Manuela Tiramani, Remi Villenave
Publikováno v:
EFSA Journal, Vol 14, Iss S1, Pp n/a-n/a (2016)
Abstract There is a fundamental change in thinking within the regulatory community due to a better understanding of the underlying biology of adverse effects to human health and the environment. The development of alternatives to use laboratory anima
Externí odkaz:
https://doaj.org/article/31cd481e3da74de39492e49948b64d3f
Autor:
Frank Bringezu, Phillip Bellion, Alexander Amberg, Jeffrey M. Birmingham, Alejandra Trejo-Martin, Glenn J. Myatt, Amy L. Mihalchik-Burhans, Amarjit Luniwal, Naomi L. Kruhlak, Rosalie K. Elespuru, Karen H. Watanabe-Sailor, Louise Neilson, Lidia Ceriani, Markus Frericks, Alessandro Brigo, John P. Rooney, Arun R. Pandiri, Helga Gerets, Alice Luu, Arianna Bassan, Angela White, Marc A. Beal, Federica Madia, Manuela Pavan, David Faulkner, Lennart T. Anger, Elena Lo Piparo, Marie C. Fortin, Jordi Mestres, Ian Crooks, David Woolley, Raymond R. Tice, Paul Fowler, Balasubramanian Manickam, David R. Jones, Cynthia V. Rider, Serena Manganelli, Juan Lopez-Belmonte, Gloria D. Jahnke, Kevin P. Cross, Romualdo Benigni
Publikováno v:
Comput Toxicol
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. In silico models have been developed for predicting rodent carcinogens but have not yet found general reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de085dd3094d276c69682e6dfe5bb402
https://europepmc.org/articles/PMC8967183/
https://europepmc.org/articles/PMC8967183/
Autor:
Amanda Green, Kim G. Shepard, Cheryl A. Hobbs, John Winters, Grace E. Kissling, John R. Bucher, Raymond R. Tice, Matthew D. Stout, Keith R. Shockley, Stephanie L. Smith-Roe, Michael E. Wyde, Kristine L. Witt
Publikováno v:
Environmental and Molecular Mutagenesis
The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2-year rodent cancer bioassay that included interim assessments of additional animals for genotoxicity endpoints. Male an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf997a36ab5e9ee34380de1cd749a84c
http://europepmc.org/articles/PMC7027901
http://europepmc.org/articles/PMC7027901
Autor:
Scott S. Auerbach, B. Alex Merrick, Kristine L. Witt, Ruili Huang, Alexander Sedykh, Menghang Xia, Stephanie L. Smith-Roe, Keith R. Shockley, Raymond R. Tice, Jui-Hua Hsieh
Publikováno v:
Chem Res Toxicol
Genotoxicity is a critical component of a comprehensive toxicological profile. The Tox21 Program used five quantitative high throughput screening (qHTS) assays measuring some aspect of DNA damage/repair to provide information on the genotoxic potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c5f3afa8234e89fa94c65d8a88099f
https://doi.org/10.1021/acs.chemrestox.9b00053
https://doi.org/10.1021/acs.chemrestox.9b00053