Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Raymond Piatt"'
Autor:
Stephen P. Holly, Nidhi Gera, Putianqi Wang, Alexander Wilson, Ziqiang Guan, Ling Lin, Brian Cooley, Hammodah R. Alfar, Ruchi G. Patil, Raymond Piatt, Tina M. Leisner, Wolfgang Bergmeier, Rinku Majumder, Leslie V. Parise
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3818-3828 (2019)
Abstract: We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC)
Externí odkaz:
https://doaj.org/article/cfd11219f3594d06852884f8acda0943
Autor:
Caterina Casari, David S. Paul, Sophie Susen, Cécile Lavenu-Bombled, Annie Harroche, Raymond Piatt, Kathryn O. Poe, Robert H. Lee, Marijke Bryckaert, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Wolfgang Bergmeier
Publikováno v:
Blood Advances, Vol 2, Iss 12, Pp 1417-1428 (2018)
Abstract: von Willebrand disease (VWD) type 2B is characterized by gain-of-function mutations in von Willebrand factor (VWF), enhancing its binding affinity for the platelet receptor glycoprotein (GP)Ibα. VWD type 2B patients display a bleeding tend
Externí odkaz:
https://doaj.org/article/1507902593a948d4b4b113e3cb58c34b
Autor:
David S. Paul, Caterina Casari, Congying Wu, Raymond Piatt, Swetha Pasala, Robert A. Campbell, Kathryn O. Poe, Dorsaf Ghalloussi, Robert H. Lee, Jeremy D. Rotty, Brian C. Cooley, Kellie R. Machlus, Joseph E. Italiano, Jr, Andrew S. Weyrich, James E. Bear, Wolfgang Bergmeier
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1398-1408 (2017)
Abstract: Actin reorganization regulates key processes in platelet activation. Here we examined the role of the Arp2/3 complex, an essential component in actin filament branching, in platelet function. The Arpc2 gene, encoding the p34 subunit of the
Externí odkaz:
https://doaj.org/article/44144d7cf1194f29b42a8abe4531b894
Publikováno v:
Haematologica, Vol 102, Iss 3 (2017)
Externí odkaz:
https://doaj.org/article/614fb67cd1284c7fb9fe5790ed7ab27d
Publikováno v:
J Basic Clin Physiol Pharmacol
Objectives Neurokinin 2 receptor (NK2R) agonists may be useful for treating bladder and bowel dysfunction via direct contraction of detrusor and gastrointestinal smooth muscle. The NK2R agonist [Lys5, MeLeu9, Nle10]-NKA(4–10) (LMN-NKA) induces urin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69548022098484d67abe22bb878fc0cb
https://doi.org/10.1515/jbcpp-2022-0119
https://doi.org/10.1515/jbcpp-2022-0119
Publikováno v:
Spinal Cord. 59:1013-1017
STUDY DESIGN Animal proof of principle study. OBJECTIVES Bladder and bowel dysfunction are common after spinal cord injury (SCI) and in the elderly. Neurokinin 2 receptor agonists are known to produce on-demand urination and defecation in adult SCI r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7f13c2f4950edd3fcd8094bd011d4d
https://doi.org/10.1038/s41393-021-00684-8
https://doi.org/10.1038/s41393-021-00684-8
Autor:
Putianqi Wang, Ruchi G. Patil, Ziqiang Guan, Ling Lin, Wolfgang Bergmeier, Brian C. Cooley, Leslie V. Parise, Nidhi Gera, Raymond Piatt, Stephen P. Holly, Tina M. Leisner, Rinku Majumder, Hammodah R. Alfar, Alexander Wilson
Publikováno v:
Blood Advances. 3:3818-3828
We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73c83ee7be7de4b882ee212c1c0e93
https://doi.org/10.1182/bloodadvances.2018030767
https://doi.org/10.1182/bloodadvances.2018030767
Publikováno v:
Spinal cord. 59(9)
Animal proof of principle study.Bladder and bowel dysfunction are common after spinal cord injury (SCI) and in the elderly. Neurokinin 2 receptor agonists are known to produce on-demand urination and defecation in adult SCI rats. This study compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39291553c71271aa4ee8f5ec49feca4d
https://pubmed.ncbi.nlm.nih.gov/34404911
https://pubmed.ncbi.nlm.nih.gov/34404911
Autor:
Dorsaf Ghalloussi, David S. Paul, Robert H. Lee, Chris I. Jones, Wolfgang Bergmeier, Dan O. Kechele, Kathleen M. Caron, Raymond Piatt, Klaus M. Hahn, Ellen C. O’Shaughnessy, Lucia Stefanini, Jonathan M. Gibbins, Kathryn O. Poe, Yacine Boulaftali
Publikováno v:
Blood. 132:1951-1962
RAP GTPases, important regulators of cellular adhesion, are abundant signaling\ud molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e99a4773ae489c79f57beb67ba50578
https://doi.org/10.1182/blood-2018-03-838714
https://doi.org/10.1182/blood-2018-03-838714
Autor:
Maria Luisa Lozano, Robert H. Lee, Wolfgang Bergmeier, Verónica Palma-Barqueros, José Rivera, Raymond Piatt, Ankita Dhenge
Publikováno v:
Science translational medicine. 11(522)
Platelet transfusions can fail to prevent bleeding in patients with inherited platelet function disorders (IPDs), such as Glanzmann's thrombasthenia (GT; integrin αIIbβ3 dysfunction), Bernard-Soulier syndrome [BSS; glycoprotein (GP) Ib/V/IX dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5918dc2d3cd37bfcaac2a3d63e02a58b
https://pubmed.ncbi.nlm.nih.gov/31826978
https://pubmed.ncbi.nlm.nih.gov/31826978