Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Raymond Nadeson"'
Publikováno v:
Anesthesia & Analgesia. :1521-1527
Recent investigations have sought to improve intrathecal analgesia by combining opioids with other classes of analgesics. In this study we assessed the ability of intrathecal midazolam to increase the potency and duration of the analgesic effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a695b635bc01a95d0d228338619bec73
https://doi.org/10.1213/01.ane.0000112434.68702.e4
https://doi.org/10.1213/01.ane.0000112434.68702.e4
Publikováno v:
Anesthesia & Analgesia. :798-805
In this study, we investigated the antinociceptive and sedative effects of the opioids fentanyl, morphine, and oxycodone given alone and in combination with two neurosteroids: alphadolone and alphaxalone. An open-field activity monitor and rotarod ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b496f21dec12a909d7b07f2151e46b3b
https://doi.org/10.1213/01.ane.0000075835.73967.f3
https://doi.org/10.1213/01.ane.0000075835.73967.f3
Autor:
Colin S. Goodchild, Raymond Nadeson
Publikováno v:
British Journal of Anaesthesia. 86:704-708
The veterinary neurosteroid anaesthetic Saffan has the same formulation as Althesin now withdrawn from human use and is a mixture of two neurosteroids, alphadolone, and alphaxalone. The molecular structures of these two pregnanes and their properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e971a8034630cd318303fdd6d36174f9
https://doi.org/10.1093/bja/86.5.704
https://doi.org/10.1093/bja/86.5.704
Publikováno v:
Pain medicine (Malden, Mass.). 10(5)
Objective. Alphadolone is a neuroactive steroid that causes antinociception in rats and analgesia in humans by interaction with spinal cord GABAA receptors. This study investigated whether alphadolone could affect morphine tolerance. Methods. Morphin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc3616db3081a67b796404e394bd385
https://pubmed.ncbi.nlm.nih.gov/19682273
https://pubmed.ncbi.nlm.nih.gov/19682273
Publikováno v:
Anesthesia and analgesia. 98(6)
Despite conflicting evidence regarding the safety of intrathecal midazolam from animal investigations, its clinical use is increasing. We investigated the potential of intrathecal midazolam to produce symptomatology suggestive of neurological damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d548920e844f58965c1a7d6e8da5c56f
https://pubmed.ncbi.nlm.nih.gov/15673922
https://pubmed.ncbi.nlm.nih.gov/15673922
Autor:
C S Goodchild, Raymond Nadeson
Publikováno v:
British journal of anaesthesia. 88(5)
Background Intrathecal administration of 5-hydroxytryptamine (5-HT) is antinociceptive to noxious heat and electrical stimuli. The contributions of different receptor subtypes to the antinociceptive effects of 5-HT are controversial. The main reasons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debdbc492ecfcafff64fc030014d9d8c
https://pubmed.ncbi.nlm.nih.gov/12067006
https://pubmed.ncbi.nlm.nih.gov/12067006
Publikováno v:
British journal of anaesthesia. 88(5)
Background Ketamine has been found to exert antinociceptive effects in animals and to be analgesic at subanaesthetic doses in humans. This study was designed to investigate the involvement of spinal cord mechanisms in the potentiation of opioid analg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671d12ae7a67fe507440a22de872ab22
https://pubmed.ncbi.nlm.nih.gov/12067007
https://pubmed.ncbi.nlm.nih.gov/12067007
Publikováno v:
British journal of anaesthesia. 86(4)
Fourteen patients scheduled for orthopaedic knee reconstruction surgery were enrolled in a prospective, double-blind, randomized study in which they received alphadolone (25-500 mg, n = 9) or placebo (lactose, n = 5) given orally 1 h after operation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c49ded12865ddbed79e13543e324d7f
https://pubmed.ncbi.nlm.nih.gov/11573627
https://pubmed.ncbi.nlm.nih.gov/11573627
Publikováno v:
Pain. 90(1-2)
This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811b277b416a3095c3ba0bc60870381e
https://pubmed.ncbi.nlm.nih.gov/11166970
https://pubmed.ncbi.nlm.nih.gov/11166970
Publikováno v:
BMC Anesthesiology, Vol 5, Iss 1, p 2 (2005)
BMC Anesthesiology
BMC Anesthesiology
Background Despite preclinical evidence suggesting a synergistic interaction between ketamine and opioids promoting analgesia, several clinical trials have not identified dosing regimens capable of eliciting a benefit in the co-administration of keta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf967dfbc070f838612e78b13528781