Výsledky vyhledávání - "Raymond Mccague"

A measure of the solid-solution extent useful for crystallisation resolution studies

Autor: Raymond McCague

Publikováno v: Tetrahedron Letters. 48:869-872

The ratio of partition coefficients of molecular components between crystal and liquor phases gives a measure of the solid-solution extent, termed D. This measure is considered useful to compare the results of resolution experiments and to make predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20a6c1854c6e9e528e70fe88e0ade068
https://doi.org/10.1016/j.tetlet.2006.11.131

Zobrazit plný text záznamu

Use of hydrolases for the synthesis of cyclic amino acids

Autor: Philip Alexander Keene, Karen E. Holt, Richard C. Lloyd, Raymond McCague, Michael C. Lloyd, Mark E. B. Smith, Jonathan P. Swift, Stephen Taylor

Publikováno v: Tetrahedron. 60:717-728

The synthesis of several cyclic amino acids that have all the necessary structural features to make them ideal scaffolds for use in medicinal chemistry is described. A key step in each synthesis is the use of hydrolase enzymes to define a chiral cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd01bbe21d741a0c6441be98e07ec874
https://doi.org/10.1016/j.tet.2003.10.116

Zobrazit plný text záznamu

Chemoenzymatic Synthesis of the Four Diastereoisomers of 4-Hydroxypipecolic Acid from N-Acetyl-(R,S)-allylglycine: Chiral Scaffolds for Drug Discovery

Autor: David A. Chaplin, Richard C. Lloyd, Raymond McCague, Dean Brick, Stephen Taylor, Mark E. B. Smith

Publikováno v: Organic Process Research & Development. 6:762-766

All four diastereoisomers of 4-hydroxypipecolic acid were prepared in a form conveniently protected for drug discovery applications with the use of industrially scaleable methodology. Resolution of the racemic starting material using proprietary acyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf2801c21998e30a6e5dc8e26644a2ea
https://doi.org/10.1021/op020017x

Zobrazit plný text záznamu

Synthesis of the Potent Antiglaucoma Agent, Travoprost

Autor: Raymond Mccague, Mark Jackson, Ian C. Lennon, Graham Ruecroft, Nicholas Parkin, Lee T. Boulton, Dean Brick, Martin E. Fox, Darren Rhodes

Publikováno v: Organic Process Research & Development. 6:138-145

A commercial synthesis of the antiglaucoma agent, travoprost 2, is described. A total of 22 synthetic steps are required to provide the single enantiomer prostanoid, with the longest linear sequence being 16 steps from 3-hydroxybenzotrifluoride. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41b64dd498ff6c66a625f10e2c52f4c5
https://doi.org/10.1021/op010097p

Zobrazit plný text záznamu

An efficient stereoselective synthesis of Z-(2S)- and Z-(2R)-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid, key intermediates in the synthesis of (2S,4S,5R)-(−)- and (2R,4R,5S)-(+)-bulgecinine

Autor: Karen E. Holt, Jonathan P. Swift, Raymond McCague, Mark E.B. Smith, Stephen J.C. Taylor

Publikováno v: Tetrahedron Letters. 43:1545-1548

A concise, scaleable route to both isomers of Z -2- tert -butoxycarbonylamino-6-hydroxyhex-4-enoic acid from 2-butyne-1,4-diol, utilizing l - and d -acylase enzymes is presented. These intermediates were readily converted to multigram quantities of N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86fdcc48199a1e6ce92e45596b0d3bb1
https://doi.org/10.1016/s0040-4039(01)02338-3

Zobrazit plný text záznamu

Highly selective directed hydrogenation of enantiopure 4-( tert -butoxycarbonylamino)cyclopent-1-enecarboxylic acid methyl esters

Autor: David A. Chaplin, Nadine Derrien, Raymond McCague, Michael C. Lloyd, Stephen Taylor, Mark E. B. Smith

Publikováno v: Tetrahedron Letters. 42:1347-1350

The use of both N-tert-butoxycarbonylamino- and hydroxyl-directed hydrogenation methodology to yield essentially single diastereomers of 3-(tert-butoxycarbonylamino)-4-hydroxycyclopentanecarboxylic acid methyl esters and 3-(tert-butoxycarbonylamino)c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a545268cb67606b0df7c53031a0e314
https://doi.org/10.1016/s0040-4039(00)02210-3

Zobrazit plný text záznamu

Synthesis Of Monohydroxylated 2-Azabicyclo[2.2.1]heptan-3-ones

Autor: Stanley M. Roberts, Ben Webb, Andrew Willetts, Raymond McCague, Susan Broad, Christopher F. Palmer, Sharon Casson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:1299-1302

Oxymercuration/demercuration of 2-benzyl-2-azabicyclo[2.2.1]hept-5-en-3-one (1) and biohydroxylation of the corresponding saturated lactam (−)-( 8 ) are compared as methods for the preparation of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones. �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58c6f74d9daaaad5d55b8854004c85fd
https://doi.org/10.1016/s0960-894x(97)00217-5

Zobrazit plný text záznamu

The synthesis of (R)-(+)-lipoic acid using a monooxygenase-catalysed biotransformation as the key step

Autor: M. Teresa Bes, Raymond Mccague, Stanley M. Roberts, Brian Adger, Sandrine Pedragosa-Moreau, Gideon Grogan, Andrew J. Willets, Peter W. H. Wan, Raffaella Villa

Publikováno v: Bioorganic & Medicinal Chemistry. 5:253-261

2-(2-Acetoxyethyl)cyclohexanone ( 4 ) was converted into the lactone (−)-( 5 ) regio- and enantioselectively using 2-oxo-Δ 3 -4,5,5-trimethylcyclopentenyl acetyl-CoA monooxygenase, an NADPH-dependent Baeyer-Villiger monooxygenase from camphor grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c6a6e923a66eda5e2e1bac78abcc02
https://doi.org/10.1016/s0968-0896(96)00234-9

Zobrazit plný text záznamu

Unexpected stereoselectivity in the cis dihydroxylation of some 2-cyclopentene-1-carboxamides

Autor: Christel Ries, Stephen Taylor, Graham Ruecroft, Sean Savage, Raymond McCague, Christopher F. Palmer

Publikováno v: Tetrahedron Letters. 37:4601-4604

While 4-substituted-2-cyclopentene-1-carboxylate esters gave no facial selectivity in the cis dihydroxylation of the olefin function with osmium tetroxide/N-methylmorpholine-N-oxide, the corresponding carboxamides unexpectedly gave high diastereosele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c5581844217d364d3cb1f8e687391b
https://doi.org/10.1016/0040-4039(96)00887-8

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání