Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Raymond M. Schiffelers"'
Autor:
Nazma F. Ilahibaks, Thomas A. Kluiver, Olivier G. deJong, Saskia C. A. deJager, Raymond M. Schiffelers, Pieter Vader, Weng Chuan Peng, Zhiyong Lei, Joost P. G. Sluijter
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract The loss‐of‐function of the proprotein convertase subtilisin–kexin type 9 (Pcsk9) gene has been associated with significant reductions in plasma serum low‐density lipoprotein cholesterol (LDL‐C) levels. Both CRISPR/Cas9 and CRISPR
Externí odkaz:
https://doaj.org/article/83cebf0ddaa745919861e6dd47a10bfc
Autor:
Nazma F. Ilahibaks, Marieke T. Roefs, Maike A. D. Brans, Christian Snijders Blok, Saskia C. A. deJager, Raymond M. Schiffelers, Pieter Vader, Zhiyong Lei, Joost P. G. Sluijter
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 9, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) are nanoscale particles that facilitate intercellular communication. They are regarded as a promising natural drug delivery system for transporting and delivering bioactive macromolecules to target cells. Recentl
Externí odkaz:
https://doaj.org/article/f0d6509b52744eafa22ce31a72ced2f4
Autor:
Laura E. Swart, Marcel H. A. M. Fens, Anita van Oort, Piotr Waranecki, L. Daniel Mata Casimiro, David Tuk, Martijn Hendriksen, Luca van den Brink, Elizabeth Schweighart, Cor Seinen, Ryan Nelson, Anja Krippner-Heidenreich, Tom O’Toole, Raymond M. Schiffelers, Sander Kooijmans, Olaf Heidenreich
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1603 (2023)
Lipid nanoparticles (LNPs) have evolved rapidly as promising delivery systems for oligonucleotides, including siRNAs. However, current clinical LNP formulations show high liver accumulation after systemic administration, which is unfavorable for the
Externí odkaz:
https://doaj.org/article/78bef8767f4d46198e0d4ecc34f83761
Autor:
Mirthe Dekker, Farahnaz Waissi, Joelle van Bennekom, Max J. M. Silvis, Nathalie Timmerman, Ingrid E. M. Bank, Joan E. Walter, Christian Mueller, A. H. Schoneveld, Raymond M. Schiffelers, Gerard Pasterkamp, Diederick E. Grobbee, Robbert J. de Winter, A. Mosterd, Dominique P. V. de Kleijn, Leo Timmers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Diagnosing stable ischemic heart disease (IHD) is challenging, especially in females. Currently, no blood test is available. Plasma extracellular vesicles (EV) are emerging as potential biomarker source. We therefore aimed to identify stress
Externí odkaz:
https://doaj.org/article/59575484f3ea45c389f59fdfc9efc0c8
Autor:
Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known. Here the authors develop a CRISPR-based reporting system to det
Externí odkaz:
https://doaj.org/article/1db2023ed1d94f558ace5b4d70bad252
Autor:
Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 3, Pp 1-12 (2019)
Therapeutics: Helping vesicles to deliver drugs inside cells An increased understanding of how extracellular vesicles (EVs) enter cells and deliver molecules will enable promising new therapies, according to researchers in the Netherlands, UK and Fra
Externí odkaz:
https://doaj.org/article/316df075eed04434ba364fbd33b3895c
Autor:
Aida Varela-Moreira, Demian van Straten, Heleen F. van Leur, Ruud W.J. Ruiter, Anil K. Deshantri, Wim E. Hennink, Marcel H.A.M. Fens, Richard W.J. Groen, Raymond M. Schiffelers
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100049- (2020)
Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a “humanized” bone ma
Externí odkaz:
https://doaj.org/article/659a110c23f844a89b5c16e99fdd91ce
Autor:
Anil K. Deshantri, Marcel H.A.M. Fens, Ruud W.J. Ruiter, Josbert M. Metselaar, Gert Storm, Sanjay N. Mandhane, Gerard H.M. Graat, Eef G.W. Lentjes, Huipin Yuan, Joost D. de Bruijn, Tuna Mutis, Anton C.M. Martens, Richard W.J. Groen, Raymond M. Schiffelers
Publikováno v:
HemaSphere, Vol 4, Iss 5, p e463 (2020)
Externí odkaz:
https://doaj.org/article/c365ef35b6cc47a7a252f44f6aa587d1
Autor:
Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P. Verhagen, Silvia Pignatelli, Minke A.E. Rab, Raymond M. Schiffelers, Elena Seiler, Wouter W. van Solinge, Joan-LLuis Vives Corrons, Lars Kaestner, Maria Mañú-Pereira, Anna Bogdanova, Richard van Wijk
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and
Externí odkaz:
https://doaj.org/article/1c68fad6745d4dcf9f1217dde473aff1
Autor:
Daan Vorselen, Susan M. van Dommelen, Raya Sorkin, Melissa C. Piontek, Jürgen Schiller, Sander T. Döpp, Sander A. A. Kooijmans, Brigitte A. van Oirschot, Birgitta A. Versluijs, Marc B. Bierings, Richard van Wijk, Raymond M. Schiffelers, Gijs J. L. Wuite, Wouter H. Roos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Red blood cell disorders are often accompanied by increased release of extracellular vesicles (EVs), but their structural and mechanical properties are not fully understood. Here, the authors show that red blood cell EVs show liposome-like mechanical
Externí odkaz:
https://doaj.org/article/ee3d649d089e45a59a0d4b1fccb687f2