Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Raymond L. Mernaugh"'
Autor:
Natalia R. Barbaro, Jason D. Foss, Dmytro O. Kryshtal, Nikita Tsyba, Shivani Kumaresan, Liang Xiao, Raymond L. Mernaugh, Hana A. Itani, Roxana Loperena, Wei Chen, Sergey Dikalov, Jens M. Titze, Bjorn C. Knollmann, David G. Harrison, Annet Kirabo
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 1009-1020 (2017)
Summary: Sodium accumulates in the interstitium and promotes inflammation through poorly defined mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through amiloride-sensitive channels including the alpha and gamma subunit
Externí odkaz:
https://doaj.org/article/d1235ed70c9742e59a814cf1462c6cee
Autor:
William N. Beavers, Andrew J. Monteith, Venkataraman Amarnath, Raymond L. Mernaugh, L. Jackson Roberts, Walter J. Chazin, Sean S. Davies, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Staphylococcus aureus infects every niche of the human host. In response to microbial infection, vertebrates have an arsenal of antimicrobial compounds that inhibit bacterial growth or kill bacterial cells. One class of antimicrobial compoun
Externí odkaz:
https://doaj.org/article/8d48f172b9184d079ef7539080bca2d8
Autor:
Lilly He, Keiko Takahashi, Lejla Pasic, Raymond L. Mernaugh, Rachel H. Kim, Takamune Takahashi, Raymond C. Harris, Tracy May, Shinya Nagasaka, Akira Shimizu, Daisuke Katagiri
Publikováno v:
Am J Physiol Renal Physiol
CD148 is a transmembrane protein tyrosine phosphatase (PTP) that is expressed in the renal vasculature, including the glomerulus. Previous studies have shown that CD148 plays a role in the negative regulation of growth factor signals (including epide
Autor:
Lejla Pasic, Annet Kirabo, Sean S. Davies, Justin H. Layer, Alan J. Simmons, Cassandra Warden, Raymond L. Mernaugh
Publikováno v:
Journal of Visualized Experiments.
Isolevuglandins (IsoLGs) are highly reactive gamma ketoaldehydes formed from H2-isoprostanes through lipid peroxidation and crosslink proteins leading to inflammation and various diseases including hypertension. Detection of IsoLG accumulation in tis
Autor:
Raymond L. Mernaugh, Mingxiao Hou, Dongzhi Wang, Wenhui Yue, Samuel C. Dudley, Xinyu Weng, Yingjie Chen, E. Kenneth Weir, Linlin Shang, Yawei Xu, Venkataraman Amarnath
Publikováno v:
Free Radical Biology and Medicine. 141:291-298
Increased levels of reactive isolevuglandins (IsoLGs) are associated with vascular inflammation and hypertension, two important factors affect heart failure (HF) development. The role of IsoLGs in HF development is unknown. Here we studied the role o
Autor:
Sharon M. Weiss, Scott T. Retterer, Shuren Hu, Girija Gaur, Raymond L. Mernaugh, Ivan I. Kravchenko
Publikováno v:
Sensors and Actuators B: Chemical. 275:394-401
Highly sensitive detection of heat denatured Herceptin® (trastuzumab), an important monoclonal antibody used in breast cancer therapeutics, is demonstrated using transverse magnetic (TM) mode suspended microring resonators (MRRs). The suspended MRRs
Publikováno v:
Biosensors, Vol 10, Iss 71, p 71 (2020)
Biosensors
Volume 10
Issue 6
Biosensors
Volume 10
Issue 6
Enzyme-catalyzed chemical reactions produce heat. We developed an enclosed, capillary-perfused nanocalorimeter platform for thermometric enzyme-linked immunosorbent assay (TELISA). We used catalase as enzymes to model the thermal characteristics of t
Autor:
Ashley Pitzer, Luciana Simao do Carmo, Natalia R. Barbaro, Justin P Van Beusecum, David G. Harrison, Aseel Alsouqi, Heitor Moreno, Wei Chen, Kim Ramil C. Montaniel, Cristi L. Galindo, Raymond L. Mernaugh, Annet Kirabo, Fernando Elijovich, Jason D. Foss, Cheryl L. Laffer, Agnes B. Fogo, Talat Alp Ikizler, Mingfang Ao, Liang Xiao, Sean S. Davies, Shilin Zhao, Roxana Loperena
Publikováno v:
Cardiovascular Research
Aims Prior studies have focused on the role of the kidney and vasculature in salt-induced modulation of blood pressure; however, recent data indicate that sodium accumulates in tissues and can activate immune cells. We sought to examine mechanisms by
Publikováno v:
Biomedical microdevices. 21(4)
Advances in microfabrication allow for highly sensitive calorimeters with dramatically reduced volume, decreased response time and increased energy resolution. These calorimeters hold the potential for designs of ELISA platforms competitive with fluo
Autor:
Arvind K. Pandey, Olivier Boutaud, Anna Dikalova, Alexander Panov, Vladimir Mayorov, Hana A. Itani, David G. Harrison, Sergey Dikalov, Sean S. Davies, John A. Oates, Raymond L. Mernaugh, Venkataraman Amarnath
Publikováno v:
Hypertension. 72
One third of adult population has hypertension and third of hypertensive patients remain hypertensive despite treatment with multiple drugs. There have been no mechanistically novel treatments for hypertension in the past 30 years. We propose that ne