Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Raymond Kaempfer"'
Autor:
Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-16 (2023)
Abstract Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulato
Externí odkaz:
https://doaj.org/article/72abed205b8b4743a7793760acc8aa32
Autor:
Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout, Raymond Kaempfer
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation. We report that this RNA-mediated ne
Externí odkaz:
https://doaj.org/article/a21711e43d92478496d8b395fce71a1b
Autor:
Raymond Kaempfer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1323 (2024)
Specific sequences within RNA encoded by human genes essential for survival possess the ability to activate the RNA-dependent stress kinase PKR, resulting in phosphorylation of its substrate, eukaryotic translation initiation factor-2α (eIF2α), eit
Externí odkaz:
https://doaj.org/article/94e8b8b8bc3340e29528927152c48a71
Autor:
Martina Kunkl, Carola Amormino, Francesco Spallotta, Silvana Caristi, Maria Teresa Fiorillo, Alessandro Paiardini, Raymond Kaempfer, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/7398ad673f554322845e852eaafa09cc
Autor:
Martina Kunkl, Carola Amormino, Francesco Spallotta, Silvana Caristi, Maria Teresa Fiorillo, Alessandro Paiardini, Raymond Kaempfer, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Staphylococcus aureus superantigens (SAgs) such as staphylococcal enterotoxin A (SEA) and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory cytokines, thus causing toxic shock and sepsis. Here we used a recently rel
Externí odkaz:
https://doaj.org/article/d0e37fe1b08242fb8f783f034f5b376d
Autor:
Raymond Kaempfer
Publikováno v:
Genes, Vol 14, Iss 5, p 974 (2023)
The transient activation of the cellular stress kinase, protein kinase RNA-activated (PKR), by double-helical RNA, especially by viral double-stranded RNA generated during replication, results in the inhibition of translation via the phosphorylation
Externí odkaz:
https://doaj.org/article/e72830ff58f843afa9d197fe59a9f2e6
Autor:
Martina Kunkl, Carola Amormino, Silvana Caristi, Valentina Tedeschi, Maria Teresa Fiorillo, Revital Levy, Andrey Popugailo, Raymond Kaempfer, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory receptor CD28 on T cells and MHC class II and B7 molecules on antig
Externí odkaz:
https://doaj.org/article/e9839b2de1114e4c8aeff04c20fb8389
Autor:
Oliver Klepsch, Lise Sarah Namer, Nadine Köhler, Raymond Kaempfer, Anna Dittrich, Fred Schaper
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short and long isoform. He
Externí odkaz:
https://doaj.org/article/fe30643aa25e4834a6e08dfbb94c75ba
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 188-200 (2017)
Tumor necrosis factor alpha (TNF-α) is expressed promptly during inflammatory responses. Efficient TNF-α mRNA splicing is achieved through a 3′ UTR element that activates RNA-dependent eIF2α protein kinase (PKR). The TNF-α RNA activator, we sho
Externí odkaz:
https://doaj.org/article/b08a0644fc3049c88278087c2467dabc
Autor:
Raymond Kaempfer, Lena Ilan, Smadar Cohen-Chalamish, Orli Turgeman, Lise Sarah Namer, Farhat Osman
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation
Externí odkaz:
https://doaj.org/article/64d3508dcf124420accf8e6bb274fa61