Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Raymond K. Tong"'
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Autor:
Priti S. Hegde, Shuang Bai, Ryan Watts, Yibing Yan, Raymond K. Tong, Rainer Brachmann, Patricia LoRusso, Amita Patnaik, Colin D. Weekes, Rashell Kinard, Jenny Wu, Jessica Li, Yan Xin
PDF file, 57K, Ratio of plasma PlGF or cNRP1 to baseline for each subject at all time points evaluated (Days 14, 21) from the Phase Ia study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fae68f878d3eeea26caf7691855252
https://doi.org/10.1158/1078-0432.22447688.v1
https://doi.org/10.1158/1078-0432.22447688.v1
Autor:
Priti S. Hegde, Shuang Bai, Ryan Watts, Yibing Yan, Raymond K. Tong, Rainer Brachmann, Patricia LoRusso, Amita Patnaik, Colin D. Weekes, Rashell Kinard, Jenny Wu, Jessica Li, Yan Xin
PDF file, 72K, Binding experiments were carried out by surface plasmon resonance (SPR) measurements on a ProteOn XPR36 (Bio-Rad Laboratories) instrument at 25{degree sign}C. For the binding competition experiment, PlGF (20μg/ml) was immobilized at h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b137772da4e6a94d6de5853f3ed25162
https://doi.org/10.1158/1078-0432.22447691.v1
https://doi.org/10.1158/1078-0432.22447691.v1
Autor:
Priti S. Hegde, Shuang Bai, Ryan Watts, Yibing Yan, Raymond K. Tong, Rainer Brachmann, Patricia LoRusso, Amita Patnaik, Colin D. Weekes, Rashell Kinard, Jenny Wu, Jessica Li, Yan Xin
PDF file, 57K, Baseline levels of Plasma PlGF for the Phase I study with MNRP1658A and Avf0776 were measured using MSD assay. Equivalent levels and similar distribution of PlGF was observed between the two clinical trials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf6dae8cc84fcd13f900e0e13f87c92
https://doi.org/10.1158/1078-0432.22447694.v1
https://doi.org/10.1158/1078-0432.22447694.v1
Autor:
Sarah L. DeVos, Y. Joy Yu Zuchero, Jennifer A. Getz, Tina Giese, Michelle E. Pizzo, Meredith E. K. Calvert, Robert C. Wells, Ryan J. Watts, Mark S. Dennis, Sulochanadevi Baskaran, Takashi Miyamoto, Xiaocheng Chen, Kylie S. Chew, Yin Zhang, Raymond K. Tong, Victoria A. Assimon, Ankita Srivastava, Adam P. Silverman, Kane Lesley Ann, Sejal S. Hall, Zachary Kevin Sweeney, Catherine Bedard, Katherine Jenkins, Mihalis Kariolis, Kwan Wanda, Do Jin Kim, Robert G. Thorne, Pascal E. Sanchez, Kirk R. Henne, Hilda Solanoy, Nicholas Liang, Cathal Mahon
Publikováno v:
Science Translational Medicine. 12
Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB transport vehicle (TV) comprising an engineered Fc fragment that exploit
Autor:
James A. Ernst, Christoph Spiess, Angie Yee, Hok Seon Kim, Jo-Anne Hongo, Ingrid Kim, Raymond K. Tong, Diana Ronai Dunshee, Farzam Farahi, Junichiro Sonoda
Publikováno v:
Protein Engineering, Design and Selection
Bispecific antibodies offer a clinically validated platform for drug discovery. In generating functionally active bispecific antibodies, it is necessary to identify a unique parental antibody pair to merge into a single molecule. However, technologie
Autor:
Saroja Ramanujan, Kristin R. Wildsmith, Y. Lu, Y. Zhang, Raymond K. Tong, Jitendra Kanodia, Dennis, Daniela Bumbaca, Sean B. Joseph, Jessica Couch, Ryan J. Watts, Kapil Gadkar, Ernst James, Jasvinder K. Atwal, Kimberly Scearce-Levie, Kwame Hoyte, W. Luk
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Anti‐transferrin receptor (TfR)‐based bispecific antibodies have shown promise for boosting antibody uptake in the brain. Nevertheless, there are limited data on the molecular properties, including affinity required for successful development of
Autor:
Mark S. Dennis, James A. Ernst, Christine Tan, Dara Y. Kallop, Raymond K. Tong, Xiaocheng Chen, Ben Chih, Melanie A. Huntley, Yanmei Lu, Shuo Zhang, Robby M. Weimer, Kwame Hoyte, Xiaoying Gao, Daniela Bumbaca, Y. Joy Yu Zuchero, Wilman Luk, Ryan J. Watts, Donald S. Kirkpatrick, Nga Bien-Ly, Lilian Phu
Publikováno v:
Neuron. 89:70-82
The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could pot
Autor:
Alexander Jaworski, Marc Tessier-Lavigne, Lino C. Gonzalez, Holly K. Gildea, Alexander W. Koch, Raymond K. Tong, Irene Tom
Publikováno v:
Science. 350:961-965
Axon pathfinding is orchestrated by numerous guidance cues, including Slits and their Robo receptors, but it remains unclear how information from multiple cues is integrated or filtered. Robo3, a Robo family member, allows commissural axons to reach