Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Raymond J. Winquist"'
Autor:
Hua Zhang, Ting Chen, Vamsidhar Velcheti, Kwok-Kin Wong, Jared E Lopes, Heather C Losey, Elaine Shum, Han Han, Hai Hu, Yuanwang Pan, Yuan Hao, Hailin Ding, Kristen E Labbe, Kayla Guidry, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Raymond J Winquist
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Small cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less than 7%. The addition of immunotherapy to chemotherapy was recently approved as first-line treatment; however, the improved clinical benefit is modest, highli
Externí odkaz:
https://doaj.org/article/5f4845cac4494148a2dafe15454c9d88
Autor:
Yee Peng Phoon, Jared E. Lopes, Lukas W. Pfannenstiel, C. Marcela Diaz-Montero, Ye F. Tian, Marc S. Ernstoff, Pauline Funchain, XiaoXia Li, Heather C. Losey, Raymond J. Winquist, Brian R. Gastman
Publikováno v:
Cancer Research. 83:1818-1818
Introduction: The development and FDA approval of drugs targeting the PD-1/PD-L1 axis has greatly shifted the paradigm of immunotherapy and has improved the clinical outcome for patients diagnosed with advanced melanoma. Despite the recent advancemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69baa6a476e073733a257791a114a416
https://doi.org/10.1158/1538-7445.am2023-1818
https://doi.org/10.1158/1538-7445.am2023-1818
Autor:
Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Kristen E Labbe, Elaine Shum, Kayla Guidry, Hai Hu, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Jared E Lopes, Heather C Losey, Raymond J Winquist, Vamsidhar Velcheti, Hua Zhang, Kwok-Kin Wong
Publikováno v:
Journal for immunotherapy of cancer. 10(9)
BackgroundSmall cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less than 7%. The addition of immunotherapy to chemotherapy was recently approved as first-line treatment; however, the improved clinical benefit is modest, highlig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d066777967055bb157d69269f541db5b
https://pubmed.ncbi.nlm.nih.gov/36472839
https://pubmed.ncbi.nlm.nih.gov/36472839
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 94
Glucagon-like peptide-1 (GLP-1) receptor agonists are extensively used in type 2 diabetic patients for the effective control of hyperglycemia. It is now clear from outcomes trials that this class of drugs offers important additional benefits to these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a810e93e5562556c26d0603e1594a0d
https://pubmed.ncbi.nlm.nih.gov/35659373
https://pubmed.ncbi.nlm.nih.gov/35659373
Publikováno v:
Advances in Pharmacology ISBN: 9780323910873
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e2eb18e44021635c90a3ac06608997
https://doi.org/10.1016/bs.apha.2022.02.005
https://doi.org/10.1016/bs.apha.2022.02.005
Publikováno v:
Biochemical Pharmacology. 208:115413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e4f26ae7dc9acd4e8722b00ef3a4015
https://doi.org/10.1016/j.bcp.2023.115413
https://doi.org/10.1016/j.bcp.2023.115413
Autor:
Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125
https://doi.org/10.1101/2021.08.29.458125
Autor:
Charles J. Cohen, Raymond J. Winquist
Publikováno v:
Biochemical Pharmacology. 151:252-262
Monogenetic diseases offer clear human validation for launching drug discovery programs in Pharma designed to develop important new medicines for unmet medical needs. However, mismatches in the genotype-phenotype of presenting patients complicate bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e86ac5fe69ac9fe0af304b03494e3e
https://doi.org/10.1016/j.bcp.2018.01.003
https://doi.org/10.1016/j.bcp.2018.01.003
Autor:
Yuanwang Pan, Ting Chen, H.C. Losey, S. Nguyen, Raymond J. Winquist, H. Ding, C. Almonte, K.E. Labbe, H. Han, Hua Zhang, K-K. Wong, Jared E. Lopes
Publikováno v:
Annals of Oncology. 32:S1169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4255e40fc55153dfbc5f89cf927d9ceb
https://doi.org/10.1016/j.annonc.2021.08.245
https://doi.org/10.1016/j.annonc.2021.08.245
Autor:
Heather C. Losey, Liliane Robillard, Bryan Vought, Bruce L Roth, Raymond J. Winquist, Jared E. Lopes, Minh Ly Nguyen, Arthur Liberzon, Rachel L. Dusek
Publikováno v:
Cancer Research. 80:2202-2202
ALKS 4230, an engineered cytokine designed for selective binding to the intermediate affinity interleukin-2 receptor (IL-2R), is being evaluated as a monotherapy and in combination with pembrolizumab in patients with advanced solid tumors. The select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2513ec43d794501ced8bc9a70c00014
https://doi.org/10.1158/1538-7445.am2020-2202
https://doi.org/10.1158/1538-7445.am2020-2202