Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Raymond J. Vavrek"'
Publikováno v:
Journal of Bone and Mineral Research. 6:807-815
The receptor subtype mediating the bradykinin (Bk)-induced burst of prostaglandin formation in osteoblasts has been studied. Bk, but not des-Arg9-Bk, induced the formation of prostaglandin E2 and prostacyclin in neonatal mouse calvarial bones incubat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7ad6221d0ff5666d61874be1edecd5
https://doi.org/10.1002/jbmr.5650060805
https://doi.org/10.1002/jbmr.5650060805
Publikováno v:
International Journal of Peptide and Protein Research. 19:334-342
Substitution of Pro residues with AIB (alpha-aminoisobutyric acid) residues in peptides provides a means of evaluating the presence of cis' proline conformations both in solution and, using bioassay data, in a receptor complex. 1H n.m.r. has been use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62660e13293de1a603ef453e0d60aafe
https://doi.org/10.1111/j.1399-3011.1982.tb02612.x
https://doi.org/10.1111/j.1399-3011.1982.tb02612.x
Publikováno v:
Journal of the American Chemical Society. 112:1357-1364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2273204deee3caee8fcb39f01c0f3b6f
https://doi.org/10.1021/ja00160a011
https://doi.org/10.1021/ja00160a011
Autor:
Raymond J. Vavrek, John M. Stewart
Publikováno v:
Journal of Cardiovascular Pharmacology. 15:S69-S74
Bradykinin antagonists effective in a great variety of kinin-responsive tissues have been developed and used to study the roles of kinins in various physiological and pathological phenomena. Structural changes required to yield antagonists and to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deb2096692eca74d5fd155944409027
https://doi.org/10.1097/00005344-199000156-00013
https://doi.org/10.1097/00005344-199000156-00013
Autor:
Lajos Gera, John M. Stewart, Chan Dc, Whalley Ej, Raymond J. Vavrek, P. A. Bunn, Eunice J. York
Publikováno v:
Biological chemistry. 382(1)
Bradykinin plays many roles in normal and pathological physiology, but rapid enzymatic degradation made elucidation of its functions extremely difficult. Development of effective degradation-resistant antagonists made it possible to delineate these r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffc79c3e5cad17a55f79b4649489fb9
https://pubmed.ncbi.nlm.nih.gov/11258669
https://pubmed.ncbi.nlm.nih.gov/11258669
Publikováno v:
Biochemical pharmacology. 46(9)
T-Kinin (Ile-Ser-bradykinin) is unique to the rat. This study characterizes the receptors involved in T-kinin activity on both the intact isolated rat uterus and membrane receptor preparations of the rat uterus. The results show that T-kinin acts thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7f1f30823c52b5aa1fcb2a84da489f
https://pubmed.ncbi.nlm.nih.gov/8240418
https://pubmed.ncbi.nlm.nih.gov/8240418
Autor:
Ricardo H. Silva, Raymond J. Vavrek, John Stewart, Ronald K. Mayfield, Philip F. Rust, Ayad A. Jaffa, Carlos P. Vio
Publikováno v:
The Journal of clinical investigation. 89(5)
This study examined the role of tissue kallikrein and kinins in renal vasodilation produced by infusion of amino acids (AA). In rats fed a 9% protein diet for 2 wk, intravenous infusion of a 10% AA solution over 60-90 min reduced total renal vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3388c603b651b90a32076cb2ec85315
https://pubmed.ncbi.nlm.nih.gov/1373739
https://pubmed.ncbi.nlm.nih.gov/1373739
Publikováno v:
Peptides ISBN: 9789401050050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a58e9943ca8306e6af00d4e0b52a1b29
https://doi.org/10.1007/978-94-011-2264-1_146
https://doi.org/10.1007/978-94-011-2264-1_146
Publikováno v:
Recent Progress on Kinins ISBN: 9783034873239
More than 200 new analogs of bradykinin have been synthesized and assayed. Analogs containing a D-aliphatic amino acid residue at position 7 and an L-aliphatic residue at position 8 are very potent antagonists of BK action on classical systems. Thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e240948b45d601fc6a4350ca4d6a6752
https://doi.org/10.1007/978-3-0348-7321-5_70
https://doi.org/10.1007/978-3-0348-7321-5_70
Publikováno v:
Recent Progress on Kinins ISBN: 9783034873239
Over 100 reduced-bond analogs of bradykinin and bradykinin antagonists were designed, synthesized, and assayed in the classic smooth muscle and blood pressure assays in a further study of the structure-activity relationships of bradykinin. Both poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dcacb5041f5bc2aa35776e9373ac455
https://doi.org/10.1007/978-3-0348-7321-5_69
https://doi.org/10.1007/978-3-0348-7321-5_69