Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Raymond J. Bergeron"'
Autor:
Stephanie Merfeld-Clauss, Pinar Zorlutuna, Bradley W. Ellis, Uryan Isik Can, Keith L. March, Raymond J. Bergeron, Dmitry O. Traktuev, Meijing Wang
Publikováno v:
Stem Cells
Heart transplantation is a life-saving therapy for end-stage organ failure. Organ deterioration during transportation limits storage to 4 hours, limiting hearts available. Approaches ameliorating organ damage could increase the number of hearts accep
Autor:
Matthias Kroiss, Yiling Xu, Sergei G. Tevosian, Graeme Eisenhofer, Raymond J. Bergeron, Arthur S. Tischler, Mercedes Robledo, Heather M. Hatch, Sudhir K. Rai, Dan Plant, Srilaxami Kalavalapalli, Robert Hromas, Karel Pacak, Henri J L M Timmers, Felix Beuschlein, David Taïeb, Bruna Calsina, Kenneth Cusi, Priyanaka Gupta, James A. Bibb, Susan Richter, Timothy J. Garrett, Fernando Bril, Prodip Bose, Hans K. Ghayee
Publikováno v:
Journal of the Endocrine Society
Background: Pheochromocytomas (PCCs) and paragangliomas (PGLs) are neuroendocrine tumors that are mostly benign. Metastatic disease occurs in about 10% of cases, and for these patients no effective therapies are available. Patients with mutations in
Autor:
Felix Beuschlein, David Taïeb, Sergei G. Tevosian, Raymond J. Bergeron, Laura Shelton, Kenneth Cusi, Srilaxmi Kalavalapalli, Karel Pacak, Arthur S. Tischler, Abhishek Jha, Soumya Luthra, James A. Bibb, Shashank Jatav, Chris Beecher, Jose G. Trevino, Kimi Kong, Fernando Bril, Prodip Bose, Arielle Click, Susan Richter, Matthias Kroiss, Priyanka Gupta, Robert Hromas, Douglas P. Lee, Austin Kirby, Katharina Langton, Yiling Xu, Mercedes Robledo, Timothy J. Garrett, Kriti Kriti, James F. Powers, Daniel Plant, Henri J L M Timmers, Bruna Calsina, Joy Guingab-Cagmat, Graeme Eisenhofer, Hans K. Ghayee, Heather M. Hatch, Sudhir K. Rai
Publikováno v:
Metabolism
Metabolism, Elsevier, 2020, 110, pp.154297. ⟨10.1016/j.metabol.2020.154297⟩
Metabolism-Clinical and Experimental, 110
Metabolism, 2020, 110, pp.154297. ⟨10.1016/j.metabol.2020.154297⟩
Metabolism, Elsevier, 2020, 110, pp.154297. ⟨10.1016/j.metabol.2020.154297⟩
Metabolism-Clinical and Experimental, 110
Metabolism, 2020, 110, pp.154297. ⟨10.1016/j.metabol.2020.154297⟩
Background Pheochromocytomas (PCCs) and paragangliomas (PGLs) are neuroendocrine tumors that are mostly benign. Metastatic disease does occur in about 10% of cases of PCC and up to 25% of PGL, and for these patients no effective therapies are availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce52549c75b861138e9ad0db9381927f
https://hal.archives-ouvertes.fr/hal-02890700
https://hal.archives-ouvertes.fr/hal-02890700
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5954-5971
Extensive structure activity relationship (SAR) studies focused on the desferrithiocin [DFT, (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid] pharmacophore have led to three different DFT analogs being evaluated clinicall
Publikováno v:
Journal of Medicinal Chemistry. 55:7090-7103
Desferrithiocin (DFT, 1) is a very efficient iron chelator when given orally. However, it is severely nephrotoxic. Structure-activity studies with 1 demonstrated that removal of the aromatic nitrogen to provide desazadesferrithiocin (DADFT, 2) and in
Publikováno v:
Tetrahedron. 67:3163-3169
The synthesis of the Rhodococcus erythropolis siderophores heterobactins A and B, and the structurally related Nocardia heterobactin, is described. Two approaches for the assembly of these asymmetric ligand donor chelators are explored. In the first
Publikováno v:
Journal of Medicinal Chemistry. 50:3302-3313
The impact of introducing a 3,6,9-trioxadecyloxyl group at various positions of the desazadesferrithiocin (DADFT) aromatic ring on iron clearance and organ distribution is described. Three DADFT polyethers are evaluated: (S)-4,5-dihydro-2-[2-hydroxy-
Publikováno v:
Synthesis. 2007:1033-1037
A short, high-yield, flexible synthesis is described for accessing vulnibactin and related siderophores, e.g., vibriobactin analogues and homologues. The spectral properties of the synthetic vulnibactin are identical with those reported for the natur
Publikováno v:
Journal of Medicinal Chemistry
The successful search for orally active iron chelators to treat transfusional iron-overload diseases, e.g., thalassemia, is overviewed. The critical role of iron in nature as a redox engine is first described, as well as how primitive life forms and
Publikováno v:
Journal of Medicinal Chemistry. 48:4120-4137
The utility of polyamines as vectors for the intracellular transport of iron chelators is further described. Consistent with earlier results with polyamine analogues, these studies underscore the importance of charge in the design of polyamine-vector