Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Raymond J Monnat"'
Autor:
Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp 1-18 (2020)
Abstract Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking these phenotypes to genotype or RNA expression at scale remains challenging. Here, we present Visual Cell Sorting, a method that physically separates h
Externí odkaz:
https://doaj.org/article/f34f0d3435be4971918d05251757a448
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009626 (2021)
Identification of cell phenotypic states within heterogeneous populations, along with elucidation of their switching dynamics, is a central challenge in modern biology. Conventional single-cell analysis methods typically provide only indirect, static
Externí odkaz:
https://doaj.org/article/6a86ed4571f04203a16e11a0d87ddd1e
Autor:
Blake T Hovde, Chloe R Deodato, Heather M Hunsperger, Scott A Ryken, Will Yost, Ramesh K Jha, Johnathan Patterson, Raymond J Monnat, Steven B Barlow, Shawn R Starkenburg, Rose Ann Cattolico
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005469 (2015)
Haptophytes are recognized as seminal players in aquatic ecosystem function. These algae are important in global carbon sequestration, form destructive harmful blooms, and given their rich fatty acid content, serve as a highly nutritive food source t
Externí odkaz:
https://doaj.org/article/38cc5dfd7d474fe79819b931816d156b
Autor:
Thomas Pavelitz, Lindsay Renfro, Nathan R Foster, Amber Caracol, Piri Welsch, Victoria Valinluck Lao, William B Grady, Donna Niedzwiecki, Leonard B Saltz, Monica M Bertagnolli, Richard M Goldberg, Peter S Rabinovitch, Mary Emond, Raymond J Monnat, Nancy Maizels
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108483 (2014)
PURPOSE:Colon cancers deficient in mismatch repair (MMR) may exhibit diminished expression of the DNA repair gene, MRE11, as a consequence of contraction of a T11 mononucleotide tract. This study investigated MRE11 status and its association with pro
Externí odkaz:
https://doaj.org/article/12fbd8e82c5d447bb904205e39b02664
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59709 (2013)
Werner syndrome (WS) is an autosomal recessive genetic instability and progeroid ('premature aging') syndrome which is associated with an elevated risk of cancer.Our study objectives were to characterize the spectrum of neoplasia in WS using a well-d
Externí odkaz:
https://doaj.org/article/67dc8b2aed6c4d2284095f7574e5ce6a
Autor:
Raymond J. Monnat
Publikováno v:
Cells, Vol 13, Iss 13, p 1077 (2024)
James German’s work to establish the natural history and cancer risk associated with Bloom syndrome (BS) has had a strong influence on the generation of scientists and clinicians working to understand other RECQ deficiencies and heritable cancer pr
Externí odkaz:
https://doaj.org/article/466226b2086d427e8384b123f050e633
Autor:
Hiep Tai Nguyen, Weiliang Tang, Andrew L. H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin, Khashayar Roohollahi, Madeline Fritzke, Elizabeth E. Hoskins, Erica Jonlin, Leslie Wakefield, Lucas B. Sullivan, Eleanor Y. Chen, Josephine Dorsman, Ruud Brakenhoff, Amanda G. Paulovich, Markus Grompe, Ramon Garcia‐Escudero, Susanne I. Wells, Agata Smogorzewska, Raymond J. Monnat
Publikováno v:
International Journal of Cancer, 153(1), 183-196. Wiley-Liss Inc.
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Fanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of developing carcinomas arising in squamous mucosal epithelia lining the mouth, proximal esophagus, vulva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015dddfce92f17afb210d60a0683723
https://doi.org/10.1002/ijc.34506
https://doi.org/10.1002/ijc.34506
Autor:
José L. McFaline-Figueroa, Sanjay Srivatsan, Andrew J. Hill, Molly Gasperini, Dana L. Jackson, Lauren Saunders, Silvia Domcke, Samuel G. Regalado, Paul Lazarchuck, Sarai Alvarez, Raymond J. Monnat, Jay Shendure, Cole Trapnell
Publikováno v:
bioRxiv
SummaryChemical genetic screens are a powerful tool for exploring how cancer cells’ response to drugs is shaped by their mutations, yet they lack a molecular view of the contribution of individual genes to the response to exposure. Here, we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81974f1a25cd3d58cf74d5b8e18a83bb
https://europepmc.org/articles/PMC10312454/
https://europepmc.org/articles/PMC10312454/
Autor:
Guangrong Qin, Jin Dai, Sylvia Chien, Timothy J. Martins, Brenda Loera, Quy Nguyen, Melanie L. Oakes, Bahar Tercan, Boris Aguilar, Lauren Hagen, Jeannine McCune, Richard Gelinas, Raymond J. Monnat, Ilya Shmulevich, Pamela S. Becker
Acute myeloid leukemia (AML) is an aggressive malignancy of myeloid progenitor cells characterized by successive acquisition of genetic alterations. This inherent heterogeneity poses challenges in the development of precise and effective therapies. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8319f859d807a96395214f8382eacf71
https://doi.org/10.1101/2023.05.24.541944
https://doi.org/10.1101/2023.05.24.541944
Autor:
William M. Grady, Beatriz Carvalho, Raymond J. Monnat, Gerrit A. Meijer, Wim van Criekinge, Cornelis J.A. Punt, Iris D. Nagtegaal, Miriam Koopman, James G. Herman, Piri Welcsh, Weiliang Tang, Sandra Mongera, Ilse Vlassenbroeck, Geert Trooskens, Petur Snaebjornsson, Victoria V. Lao, Yanxin Luo, Linda J.W. Bosch
supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a68b930d8549eb4d8c4d9afd3e1d4e
https://doi.org/10.1158/1078-0432.22454832
https://doi.org/10.1158/1078-0432.22454832