Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Raymond J, Gonzalez"'
Autor:
Katerina, Vlasakova, Jennifer, Bourque, Wendy J, Bailey, Shetal, Patel, Elizabeth G, Besteman, Raymond J, Gonzalez, Frank D, Sistare, Warren E, Glaab
Publikováno v:
Toxicological Sciences. 187:219-233
The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would provide a valuable tool in early exploratory animal studies to understand potential drug liabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b063b32a14b4046a9ff7c68d7d3fd6a5
https://doi.org/10.1093/toxsci/kfac030
https://doi.org/10.1093/toxsci/kfac030
Autor:
Kristal Kaan, Nicole Boo, Yu-Chi Angela Juang, Chandra S. Verma, Kaustav Biswas, Ruchia Duggal, Christopher J. Brown, Bhvana Bhatt, Chunhui Huang, Simon Ng, Ahmad Sadruddin, Nianyu Jason Li, Srinivasaraghavan Kannan, Shuhui Lim, Xiang Yu, Charles W. Johannes, Andrea M. Peier, Anthony W. Partridge, Erjia Wang, Lan Ge, Michael Garrigou, Pooja Gopal, Gireedhar Venkatachalam, Brian Henry, Nicolas Boyer, Khong Ming Peh, Tsz Ying Yuen, Raymond J. Gonzalez, Feifei Chen, Tomi K. Sawyer, Alexander Stoeck, Peter Orth, David P. Lane
Publikováno v:
Chemical Science
Macrocyclic peptides have the potential to address intracellular protein–protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons for applying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf11d85ecefa612930f36d6645df5d18
http://europepmc.org/articles/PMC8672774
http://europepmc.org/articles/PMC8672774
Autor:
Neil French, Christopher E. Goldring, Rosalind E. Jenkins, Samantha Korver, Kevin Park, Joanne M. Bowen, Raymond J. Gonzalez, Kara Pearson
Publikováno v:
ARCHIVES OF TOXICOLOGY
Archives of Toxicology
Archives of Toxicology
Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during preclinical and clinical drug therapy. DILI is a leading cause of candidate drug attrition, withdrawal and in clinic, is the primary cause of acute liver failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f774f2741819141c57379b00a0f2ad
http://livrepository.liverpool.ac.uk/3133119/1/Korver2021_Article_TheApplicationOfCytokeratin-18.pdf
http://livrepository.liverpool.ac.uk/3133119/1/Korver2021_Article_TheApplicationOfCytokeratin-18.pdf
Autor:
Shu-An Lin MS, Donna L. Suresch, Brett Connolly, Gebre Mesfin, Raymond J. Gonzalez, Manishkumar R. Patel, Diane Shevell, Timothy Johnson, Bohumil Bednar
Publikováno v:
Molecular Imaging, Vol 14 (2015)
Drug-induced vascular injury (DIVI), defined as arterial medial degeneration/necrosis usually associated with perivascular inflammation, is frequently observed in the mesenteric arteries of rats but the relevance to humans remains a hurdle for drug d
Externí odkaz:
https://doaj.org/article/e2e491c7f47b418b836d1b20b48456a1
Autor:
Allen Kaczor, Qiuwei Xu, José A. Lebrón, Amy G Aslamkhan, John Imredy, Yan Yu, Christina Wei, Matthew Kuhls, Kaushik Mitra, Michael P. Ruth, Kara Pearson, Andy Liaw, Liping Liu, Heather Vu, Frank D. Sistare, Raymond J. Gonzalez
Publikováno v:
Chemical Research in Toxicology. 32:1528-1544
Human hepatocellular carcinoma cells, HepG2, are often used for drug mediated mitochondrial toxicity assessments. Glucose in HepG2 culture media is replaced by galactose to reveal drug-induced mitochondrial toxicity as a marked shift of drug IC50 val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17919a6e2badadf5dc61110f063a9a8b
https://doi.org/10.1021/acs.chemrestox.9b00033
https://doi.org/10.1021/acs.chemrestox.9b00033
Autor:
José A. Lebrón, Donna Lynch, Kristin Geddes, Stephen Pacchione, Hong Duong, Yutai Li, Warren E. Glaab, Alema Galijatovic-Idrizbegovic, Frank D. Sistare, Wen Kang, Raymond J. Gonzalez, Daniel J. Holder, Kyeongmi Cheon, Kara Pearson, Nanyan Rena Zhang, Alex M Tamburino, Michael J. Hafey, Raymond Evers, Keith Q. Tanis, Lisa LaFranco-Scheuch
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 170(1)
Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical animal models. Here we present the development of a novel rat model using siRNA knockdown (KD) of Bsep th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0bf4d9d28084bd888d7572b62cf84e
https://pubmed.ncbi.nlm.nih.gov/30903168
https://pubmed.ncbi.nlm.nih.gov/30903168
Autor:
Timothy E. Johnson, Frank D. Sistare, Brett Connolly, Warren E. Glaab, Thomas Philip, Raymond J. Gonzalez, Shu-An Lin, Gebre M Mesfin, Bohumil Bednar, Shetal Patel, Lisa LaFranco-Scheuch
Publikováno v:
Toxicologic pathology. 45(5)
Lack of biomarkers specific to and either predictive or diagnostic of drug-induced vascular injury (DIVI) continues to be a major obstacle during drug development. Biomarkers derived from physiologic responses to vessel injury, such as inflammation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db09844dd2eab65c89e092873139b476
https://pubmed.ncbi.nlm.nih.gov/28830331
https://pubmed.ncbi.nlm.nih.gov/28830331
Autor:
Tanja S. Zabka, Bradley E. Enerson, Michael P. Lawton, Raymond J. Gonzalez, Marshall S. Scicchitano, Peter Hoffmann, Deidre A. Dalmas, Mark Cameron, James L. Weaver, Nicholas M.P. King, Holly W. Smith, Igor Mikaelian, Silvia Guionaud, Roberta A. Thomas
Publikováno v:
Toxicologic Pathology. 42:635-657
Better biomarkers are needed to identify, characterize, and/or monitor drug-induced vascular injury (DIVI) in nonclinical species and patients. The Predictive Safety Testing Consortium (PSTC), a precompetitive collaboration of pharmaceutical companie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682df031e89863ce652005e46452377f
https://doi.org/10.1177/0192623314525686
https://doi.org/10.1177/0192623314525686
Autor:
Wendy J. Bailey, Raymond J. Gonzalez, Craig E. Thomas, Hima Patel, Frank D. Sistare, Nagaraja Muniappa, Warren E. Glaab, Pam Devlin, Valerie Hamilton, Dan Holder, Diane Hamlin
Publikováno v:
Toxicological Sciences. 130:229-244
Alanine aminotransferase (ALT) activity is the most frequently relied upon reference standard for monitoring liver injury in humans and nonclinical species. However, limitations of ALT include a lack of specificity for diagnosing liver injury (e.g.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93259bc8f33319aba2c2cf51f4236785
https://doi.org/10.1093/toxsci/kfs243
https://doi.org/10.1093/toxsci/kfs243
Autor:
Brett Connolly, Manishkumar Patel, Bohumil Bednar, Donna L. Suresch, Raymond J. Gonzalez, Timothy D. Johnson, Diane Shevell, Gebre M Mesfin, Shuan Lin
Publikováno v:
Molecular Imaging, Vol 14 (2015)
Drug-induced vascular injury (DIVI), defined as arterial medial degeneration/necrosis usually associated with perivascular inflammation, is frequently observed in the mesenteric arteries of rats but the relevance to humans remains a hurdle for drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d8876c52b8314f9105f47b15c138d8
https://doaj.org/article/e2e491c7f47b418b836d1b20b48456a1
https://doaj.org/article/e2e491c7f47b418b836d1b20b48456a1