Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms

Autor: Nathalie Rousselet, Didier Jean, Raymond Frade

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2006, 25 (10), pp.1474-1484. ⟨10.1038/sj.onc.1209196⟩
Oncogene, 2006, 25 (10), pp.1474-1484. ⟨10.1038/sj.onc.1209196⟩

International audience; Cathepsin L, a cysteine protease, is overexpressed in human tumor cells and plays a major role in melanoma progression. Our aim was herein to identify molecular mechanisms, which contribute to its overexpression. We found that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f236b31301ca06f50b5e4bbcb1c4d36
https://doi.org/10.1038/sj.onc.1209196

Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human cell surface triggers pp60src and Akt-GSK3 activities upstream and downstream to PI 3-kinase, respectively

Autor: Monique Barel, Raymond Frade, Muriel Le Romancer, Michelle Balbo

Publikováno v: European Journal of Immunology. 33:2557-2566

We previously demonstrated that CR2 activation on human B lymphocyte surface specifically triggered tyrosine phosphorylation of the 95-kDa nucleolin, this leading to its binding on SH2 domains of p85 sub-unit of PI 3-kinase and to activation of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d64163ec163b0c2bfea3f67a11fd40
https://doi.org/10.1002/eji.200324059

Structure and functions of proteases which cleave human C3 and are expressed on normal or tumor human cells: some are involved in tumorigenic and metastatic properties of human melanoma cells

Autor: Raymond Frade

Publikováno v: Immunopharmacology. 42:39-45

Human C3 is a multipotent molecule which participates to different events involved in immune response as complement activation, antigen presentation, cell–cell interactions and cell proliferation. Thus, proteinases which cleave C3 may modify C3-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f5b578f724cca3fc2346f1aa3bb7ca
https://doi.org/10.1016/s0162-3109(99)00028-4

Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53

Autor: Raymond Frade, Michelle Balbo, Pascal Drané, Monique Barel

Publikováno v: Oncogene. 15:3013-3024

Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. Immunoblotting or immunopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b435dd205407871434b76187248e0c20
https://doi.org/10.1038/sj.onc.1201492

Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein

Autor: Monique Barel, Michelle Balbo, Aline Gauffre, Raymond Frade

Publikováno v: Molecular Immunology. 32:389-397

Epstein-Barr virus/C3d receptor (CR2, CD21) interacts with three intracellular proteins: the p53 anti-oncoprotein expressed in human B lymphoma cells, the p68 calcium binding protein expressed in normal B lymphocytes and the nuclear p120 ribonucleopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e789aa17f4f426b5c06c2670c0940a9
https://doi.org/10.1016/0161-5890(95)00005-y