Zobrazeno 1 - 10 of 97 pro vyhledávání: '"Raymond F. Novak"'
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The Evolution of
Autor: Edward T, Morgan, Raymond F, Novak, James R, Halpert, Eric F, Johnson, Jeffrey C, Stevens
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 51(1)
This article was solicited to commemorate the 50th anniversary of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ee6b5ea2b7edda0326c20fe93fd0431
https://pubmed.ncbi.nlm.nih.gov/36273824
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3
Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
Autor: Raymond F. Novak, Brian Kress, G. Gordon Gibson, Michael Boberg, Jeffrey G. Sarver, Nico P. E. Vermeulen, Steven A. Wrighton, Phillip S. Portoghese, Nicholas Bodor, Kenneth Bachmann, Jack Hinson, Amarjit Luniwal, M. Teresa Serafini, Donald J. Birkett, Daniel Koehler, David R. Hawkins, Hiroshi Masumoto, Paul W. Erhardt, Gabrielle Hawksworth, Christopher J. Trabbic
Publikováno v: Erhardt, P, Bachmann, K, Birkett, D, Boberg, M, Bodor, N, Gibson, G, Hawkins, D, Hawksworth, G, Hinson, J, Koehler, D, Kress, B, Luniwal, A, Masumoto, H, Novak, R, Portoghese, P, Sarver, J, Serafini, M T, Trabbic, C, Vermeulen, N & Wrighton, S 2021, ' Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report) ', Pure and Applied Chemistry, vol. 93, no. 3, pp. 273-403 . https://doi.org/10.1515/pac-2018-0208
Pure and Applied Chemistry, 93(3), 273-403. IUPAC Secretariat
© 2021 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/ 2021.This project orig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8509c6fdda44736f10a565af150c11
https://research.vu.nl/en/publications/3219fb5d-9fad-4fb4-bd54-21dbe7ffe060
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4
Insights into Insulin-Mediated Regulation of CYP2E1: miR-132/-212 Targeting of CYP2E1 and Role of Phosphatidylinositol 3-Kinase, Akt (Protein Kinase B), Mammalian Target of Rapamycin Signaling in Regulating miR-132/-212 and miR-122/-181a Expression in Primary Cultured Rat Hepatocytes
Autor: Nithin Tumma, Alan A. Dombkowski, Raymond F. Novak, Theresa Gratsch, Upasana Shukla
Publikováno v: Drug Metabolism and Disposition. 41:1769-1777
Several microRNAs (miRNAs) were selected for characterization of their response to insulin signaling based on in silico predictions of targeting CYP2E1 mRNA and previous reports implicating their role in hepatic metabolism and disease. CYP2E1 express
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d253d5c4fde0997d703b4ff1d94d5771
https://doi.org/10.1124/dmd.113.052860
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5
Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes
Autor: B. Bhaskar Gollapudi, Daniela Cukovic, J. Craig Rowlands, Raymond F. Novak, Alan A. Dombkowski, Robert A. Budinsky, Mohamed A. Abdelmegeed
Publikováno v: Chemosphere. 85:232-238
Toxicogenomics was used to examine mRNA expression profiles obtained from primary rat hepatocytes treated for 24 h with 0.01 or 1.0 nM 2,3,7,8-tetrachlorodibenzo- p -dioxin (2,3,7,8-TCDD), 0.02 or 2.0 nM 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e488b3353611c841d428291ad23b5a9a
https://doi.org/10.1016/j.chemosphere.2011.06.026
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6
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells
Autor: Alice Hudder, Kim Zukowski, Raymond F. Novak, Jie Zheng
Publikováno v: Cancer Letters. 296:74-87
Akt and mTOR are therapeutic targets for the treatment of cancer. The effects of inhibiting mTOR, with rapamycin, and Akt, with A-443654, concurrently, on cell morphology, cell proliferation, the cell cycle, and apoptosis were examined using the beni
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https://doi.org/10.1016/j.canlet.2010.03.018
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7
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: Biomarkers of progression
Autor: Larry Tait, Jie Zheng, So Hee Kim, Fred R. Miller, Raymond F. Novak
Publikováno v: International Journal of Cancer. 124:2813-2828
The MCF10A human breast epithelial cell lineage includes the benign MCF10A cells, premalignant cells (MCF10AT, MCF10ATG3B) and malignant MCF10CA1a tumor cells. The premalignant and tumor cells recapitulate the progressive alterations associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9fb2137868950f7e6c57771a45e670
https://doi.org/10.1002/ijc.24278
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8
THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK
Autor: Mohamed A. Abdelmegeed, Sang K. Kim, Raymond F. Novak
Publikováno v: Drug Metabolism and Disposition. 34:683-689
The antioxidant activity of flavonoids, directly through scavenging oxidizing species and indirectly through modulating drug-metabolizing enzyme activities, is associated with chemopreventive and chemotherapeutic effects. However, little published in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822ded1e0abc7b6a099b362611d5ca73
https://doi.org/10.1124/dmd.105.007666
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9
Proceedings of a workshop on DNA adducts: Biological significance and applications to risk assessment Washington, DC, April 13–14, 2004
Autor: Bennett Van Houten, R. Julian Preston, Syril D. Pettit, Miriam Sander, Julie A. Skare, Jean Cadet, Gary M. Williams, B. Bhaskar Gollapudi, Lawrence J. Marnett, Raymond F. Novak, Daniel A. Casciano, Sheila M. Galloway
Publikováno v: Toxicology and Applied Pharmacology. 208:1-20
In April 2004, the Health and Environmental Sciences Institute, a branch of the International Life Sciences Institute, with support from the National Institute of Environmental Health Sciences, organized a workshop to discuss the biological significa
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https://doi.org/10.1016/j.taap.2004.12.012
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10
Acetoacetate Induces CYP2E1 Protein and Suppresses CYP2E1 mRNA in Primary Cultured Rat Hepatocytes
Autor: Mohamed A. Abdelmegeed, Raymond F. Novak, Nicholas J. Carruthers, Sang K. Kim, Kimberley J. Woodcroft
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 315:203-213
The ketone body acetoacetate (AA) in the absence of insulin or in the presence of diabetic insulin levels decreases CYP2E1 mRNA expression in a concentration- and time-dependent manner in primary cultured rat hepatocytes. AA activates p70 ribosomal S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce03e5a2546cae34262b4922f5b1ce
https://doi.org/10.1124/jpet.105.084608
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