Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Raymond F. Aten"'
Publikováno v:
Biology of Reproduction. 59:1069-1076
Luteal regression is associated with the generation of reactive oxygen species (ROS). To determine the nature of the ROS generator, cells isolated from luteinized rat ovaries were examined for ROS production using luminol-amplified chemiluminescence
Publikováno v:
Biology of Reproduction. 58:407-413
The corpus luteum is notable for very high levels of ascorbic acid. In luteal cells, ascorbic acid depletion occurs as a result of consumption during radical scavenging, inhibition of ascorbic acid uptake, and stimulation of its secretion. Oxidation
Publikováno v:
Biology of Reproduction. 54:399-406
Luteal ascorbic acid depletion by LH and prostaglandin (PG) F2 alpha is well known, but how such depletion occurs is not. We therefore investigated the nature and regulation of ascorbic acid uptake and depletion in the rat CL and luteal cells. In viv
Publikováno v:
Molecular Human Reproduction. 2:549-554
The infiltration of leukocytes is a characteristic feature of luteolysis in humans. Leukocytes are known to generate physiological inducers of cell stress such as cytokines which have been implicated as mediators of functional luteal regression. In c
Publikováno v:
Molecular Endocrinology. 9:1431-1440
Induction of heat shock protein 70 (HSP-70) is associated with inhibition of hormone-sensitive steroidogenesis and interruption of cholesterol translocation to or into the mitochondria. A number of pharmacological and physiological inhibitors of lute
Publikováno v:
Biology of Reproduction. 53:1110-1117
Previous studies have shown that the induction of functional luteolysis (loss of progesterone production) with either prostaglandin F2 alpha (PGF2 alpha) treatment or hypophysectomy (APX) diminished neutral cholesteryl ester hydrolase (CEH) activity
Autor:
Stephanie R. Goodman, Raymond F. Aten, Ervin E. Jones, Harold R. Behrman, Gabriele Rossi, Alan S. Penzias, Fayek N. Shamma
Publikováno v:
Journal of the Society for Gynecologic Investigation. 2:623-629
We investigated whether GnRH has the properties of a growth hormone-releasing factor in vivo in a mammalian species. Sexually mature female Sprague-Dawley rats were prepared for in vivo dynamic hormone testing. The rats were assigned to one of four g
Publikováno v:
Endocrinology. 136:1775-1781
Heat shock protein (HSP) synthesis increases in cells with a broad range of stress conditions. We recently showed that induction of HSP-70 is associated with inhibition of hormone-sensitive steroidogenesis, but not hormone-sensitive cAMP accumulation
Publikováno v:
Reproductive Medicine Review. 2:153-180
Several conclusions can be drawn from a review of the formation, function and regression of the corpus luteum. Ovulation and luteinization encompass degenerative and growth changes. Inflammatory conditions associated with ovulation lead to the breakd
Publikováno v:
Endocrinology. 133:690-698
Structural luteolysis was found decades ago to be induced by PRL in the hypophysectomized rat, but the mechanisms of this process are unknown. To gain information on mechanisms of luteal involution, we developed an animal model that circumvented comp