Výsledky vyhledávání - "Raymond F, Suckow"

Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine

Autor: Briana K. Chen, Donald W. Landry, Shi-Xian Deng, Xiaoming Xu, Christine A. Denny, Denis J. David, Victor M. Luna, Christina T LaGamma, Indira Mendez-David, Rebecca A. Brachman, Alain M. Gardier, Abhishek Shah, Thomas B. Cooper, Raymond F. Suckow

Publikováno v: Neuropsychopharmacology

Enhancing stress resilience in at-risk populations could significantly reduce the incidence of stress-related psychiatric disorders. We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ab22efe3b7a5a1bf0cf35723e91cde
https://doi.org/10.1038/s41386-020-0714-z

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Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO

Autor: Ludovic Leriche, Thomas B. Cooper, Anissa Abi-Dargham, Agnès Montagne, Valérie Brunner, Simon Joseph, Marlène Guiraud, Florence Gaudoux, Patrick Carberry, Mark Slifstein, Chaitanya R. Divgi, Raymond F. Suckow, Pierre Sokoloff, Ragy R. Girgis, Françoise Tonner, Shunichi Oya

Publikováno v: Psychopharmacology. 237:519-527

F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7f82ff674fc257a245221e943447376
https://doi.org/10.1007/s00213-019-05387-w

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Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults: A controlled clinical trial

Autor: Darsol Seok, Leslie M. Shaw, Anne M. Fagan, Joanne C. Beer, Raymond F. Suckow, John R. Cirrito, Jin-Moo Lee, Teresa Waligorska, Magdalena Korecka, B. Joy Snider, John C. Morris, Yvette I. Sheline, Irem Aselcioglu

Publikováno v: Neurology

ObjectiveTo determine whether treatment with escitalopram compared with placebo would lower CSF β-amyloid 42 (Aβ42) levels.RationaleSerotonin signaling suppresses Aβ42 in animal models of Alzheimer disease (AD) and young healthy humans. In a prosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe286508ee022a3eb9247d5abbb92ab
https://europepmc.org/articles/PMC7713735/

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Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors

Autor: Uwe Rudolph, Raymond F. Suckow, Rebecca S. Benham, Nishani B. Hewage, Elif Engin

Publikováno v: Behavioural Brain Research. 332:172-179

Deficits in neuronal inhibition via gamma-aminobutyric acid (GABA) type A receptors (GABAA-Rs) are implicated in the pathophysiology of major depressive disorder and the therapeutic effects of current antidepressant treatments, however, the relevant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cda4b74d009369cf9e6a09b52d98b3b
https://doi.org/10.1016/j.bbr.2017.05.063

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Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats

Autor: Bin Dong, Thomas B. Cooper, Borehalli M. Shilpa, Shan Xie, Mihran J. Bakalian, Arjun Goyal, Raymond F. Suckow, Victoria Arango, K. Yaragudri Vinod, J. John Mann, Relish Shah

Publikováno v: J Psychiatr Res

Major depressive disorder (MDD) is common, often under-treated and a leading cause of disability and mortality worldwide. The causes of MDD remain unclear, including the role of the endocannabinoid system. Intriguingly, the prevalence of depression i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3517caff3931ed32fe4759e985887ec8
https://europepmc.org/articles/PMC6916267/

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Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [

Autor: Mark, Slifstein, Anissa, Abi-Dargham, Ragy R, Girgis, Raymond F, Suckow, Thomas B, Cooper, Chaitanya R, Divgi, Pierre, Sokoloff, Ludovic, Leriche, Patrick, Carberry, Shunichi, Oya, Simon K, Joseph, Marlène, Guiraud, Agnès, Montagne, Valérie, Brunner, Florence, Gaudoux, Françoise, Tonner

Publikováno v: Psychopharmacology. 237(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::daaba2ad04576f3a57ec70c3ddd92730
https://pubmed.ncbi.nlm.nih.gov/31773210

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Ovarian hormones mediate the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-hydroxynorketamine in female mice

Autor: Thomas B. Cooper, Xiaoming Xu, Raymond F. Suckow, Rebecca A. Brachman, Shi-Xian Deng, Donald W. Landry, Briana K. Chen, Christine A. Denny, Christina T. LaGamma

BACKGROUNDFemales are more likely than males to develop major depressive disorder (MDD) after exposure to stress. We previously reported that the administration of (R,S)-ketamine before stress can prevent stress-induced depressive-like behavior in ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5263d19a46b0837bf0fc338436096d

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Ketamine metabolite pilot study in a suicidal depression trial

Autor: J. John Mann, Hanga Galfalvy, Ainsley K. Burke, Raymond F. Suckow, Tse-Hwei Choo, Michael F. Grunebaum, Thomas B. Cooper, Michelle S. Parris

Publikováno v: J Psychiatr Res

Ketamine shows promise as a rapidly-acting treatment for depression and suicidal ideation, but side effects and abuse potential limit its use. Understanding its mechanism of action could help develop analogous but safer drugs. This post hoc study exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59a626e0290b354fbfa4808ff6e197b
https://pubmed.ncbi.nlm.nih.gov/31550622

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Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression

Autor: Stephanie T. Mulhern, Matthew S. Milak, Zhengchao Dong, Dikoma C. Shungu, J. John Mann, Raymond F. Suckow, Lawrence S. Kegeles, John G. Keilp, Rain Rashid, Xuejing Lin, R. Todd Ogden, Michael F. Grunebaum, Xiangling Mao, Thomas B. Cooper

Publikováno v: JAMA Network Open. 3:e2013211

Importance A single subanesthetic dose of ketamine produces an antidepressant response in patients with major depressive disorder (MDD) within hours, but the mechanism of antidepressant effect is uncertain. Objective To evaluate whether ketamine dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d7c6f0611983721b1e521047c2525c
https://doi.org/10.1001/jamanetworkopen.2020.13211

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