Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Raymond E. Moellering"'
Autor:
Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed over 6 million individuals worldwide and continues to spread in countries where vaccines are not yet widely available or its citizens are hesitant to become vaccinated.
Externí odkaz:
https://doaj.org/article/5cf75b97da964ea0a46a9ad54694937e
Autor:
Gang Li, Jeffrey E. Montgomery, Mark A. Eckert, Jae Won Chang, Samantha M. Tienda, Ernst Lengyel, Raymond E. Moellering
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The interrogation of enzyme activity involves the ensemble averaging of many cells, loss of spatial relationships and is often biased to abundant proteins. Here the authors develop activity-dependent proximity ligation to quantify enzyme activity at
Externí odkaz:
https://doaj.org/article/4e4b7627eb0e4daf97d1194c3f8abb64
Autor:
Shreya Mitra, Jeffrey E. Montgomery, Matthew J. Kolar, Gang Li, Kang J. Jeong, Bo Peng, Gregory L. Verdine, Gordon B. Mills, Raymond E. Moellering
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.
Externí odkaz:
https://doaj.org/article/88dae4a0195d4721a84d58ee911ac1ec
Autor:
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley
Publikováno v:
Cancer Discovery. 13:1002-1025
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD,
Publikováno v:
ACS Chemical Biology. 18:91-101
Methylglyoxal (MGO), a reactive metabolite byproduct of glucose metabolism, is known to form a variety of posttranslational modifications (PTMs) on nucleophilic amino acids. For example, cysteine, the most nucleophilic proteinogenic amino acid, forms
Autor:
Thomas E. Speltz, Zeyu Qiao, Colin S. Swenson, Xianghang Shangguan, John S. Coukos, Christopher W. Lee, Deborah M. Thomas, Jesse Santana, Sean W. Fanning, Geoffrey L. Greene, Raymond E. Moellering
Publikováno v:
Nature Biotechnology. 41:541-551
Autor:
Lewis C. Cantley, Harold Varmus, Raymond E. Moellering, John M. Asara, Chen Zhang, Reuben J. Shaw, Steven S. Gross, Bryan Ngo, Miriam Sindelar, John S. Coukos, Qiuying Chen, Min Yuan, Roger J. Liang, Pablo E. Hollstein, David Wu, Jae Won Chang, Eric E. Gardner, John R. Ferrarone, Benjamin D. Stein
Figure S7. Tpi1 is required for tumor growth in KP and KPL LUAD models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222d1f5d233f06829de0b48c421cb0f7
https://doi.org/10.1158/2159-8290.22553374
https://doi.org/10.1158/2159-8290.22553374
Autor:
Lewis C. Cantley, Harold Varmus, Raymond E. Moellering, John M. Asara, Chen Zhang, Reuben J. Shaw, Steven S. Gross, Bryan Ngo, Miriam Sindelar, John S. Coukos, Qiuying Chen, Min Yuan, Roger J. Liang, Pablo E. Hollstein, David Wu, Jae Won Chang, Eric E. Gardner, John R. Ferrarone, Benjamin D. Stein
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a4888ce7db00a4ab236f555bdd0a96
https://doi.org/10.1158/2159-8290.c.6534613.v2
https://doi.org/10.1158/2159-8290.c.6534613.v2
Publikováno v:
Israel Journal of Chemistry. 63
Autor:
John S. Coukos, Raymond E. Moellering
Publikováno v:
ACS Chemical Biology
Methylglyoxal (MGO) is a reactive byproduct formed by several metabolic precursors, the most notable being triosephosphates in glycolysis. While many MGO-mediated adducts have been described, the reactivity and specific biomolecular targets of MGO re