Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Raymond E. Hulse"'
Publikováno v:
eLife, Vol 7 (2018)
We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membra
Externí odkaz:
https://doaj.org/article/4fba5978103d4fb8a50805315ff8f96b
Autor:
Raymond E. Hulse, David E. Clapham
Publikováno v:
Nature. 595:654-655
Activation of the CatSper membrane ion channel triggers enhanced sperm motility, and this protein complex is required for male fertility. Structural data now provide insights into the channel, and offer a few surprises, too. Cryo-EM data sheds light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f291a30a82f3f3e55e02af2b104dbf
https://doi.org/10.1038/d41586-021-01945-5
https://doi.org/10.1038/d41586-021-01945-5
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
We report the near atomic resolution (3.1 Å) of the polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6aab9ba4ed67c0042966d8fbfa949d4
https://doi.org/10.1101/287367
https://doi.org/10.1101/287367
Autor:
Qufei Li, Eduardo Perozo, Klaus Schulten, David Medovoy, Sherry Wanderling, Raymond E. Hulse, Anthony A. Kossiakoff, Carlos A. Villalba-Galea, Abhishek Singharoy, Ryan McGreevy, Benoît Roux, Marcin Paduch
Publikováno v:
Nature Structural & Molecular Biology. 21:244-252
The transduction of transmembrane electric fields into protein motion plays an essential role in the generation and propagation of cellular signals. Voltage-sensing domains (VSD) carry out these functions through reorientations of S4 helix with discr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53146d8e8a36f182eadde586370a8ec
https://doi.org/10.1038/nsmb.2768
https://doi.org/10.1038/nsmb.2768
Publikováno v:
Journal of the American Chemical Society. 134:16360-16369
Distance determination from an echo intensity modulation obtained by pulsed double electron-electron resonance (DEER) experiment is a mathematically ill-posed problem. Tikhonov regularization yields distance distributions that can be difficult to int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ee28f902a23e53ddd4b91a6a3045f8
https://doi.org/10.1021/ja3069038
https://doi.org/10.1021/ja3069038
Autor:
Mahmoud Moradi, Joseph R. Sachleben, Po-Chao Wen, Raymond E. Hulse, Emad Tajkhorshid, Eduardo Perozo
Publikováno v:
Biochemistry
The potassium channel KcsA offers a unique opportunity to explicitly study the dynamics of the moving parts of ion channels, yet our understanding of the extent and dynamic behavior of the physiologically relevant structural changes at the inner gate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5798f15cd0e10cb6d8ef361a38afa6
https://doi.org/10.1021/bi500168u
https://doi.org/10.1021/bi500168u
Publikováno v:
Cellular and Molecular Life Sciences. 65:2574-2585
The accumulation of aggregates of amyloidogenic peptides is associated with numerous human diseases. One well studied example is the association between deposition of amyloid β (Aβ) and Alzheimer’s disease. Insulin degrading enzyme and neprilysin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a8e40f71f95809b142fcfda2378d09
https://doi.org/10.1007/s00018-008-8112-4
https://doi.org/10.1007/s00018-008-8112-4
Autor:
Eline J. Koers, Olivier Ouari, Elwin A. W. van der Cruijsen, Raymond E. Hulse, Claire Sauvée, Paul Tordo, Marc Baldus, Markus Weingarth, Eduardo Perozo
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2015, 21 (37), pp.12971-12977. ⟨10.1002/chem.201501376⟩
Chemistry-A European Journal, 2015, 21 (37), pp.12971-12977. ⟨10.1002/chem.201501376⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2015, 21 (37), pp.12971-12977. ⟨10.1002/chem.201501376⟩
Chemistry-A European Journal, 2015, 21 (37), pp.12971-12977. ⟨10.1002/chem.201501376⟩
International audience; Dynamic nuclear polarization (DNP) has beenshown to greatly enhance spectroscopic sensitivity, creatingnovel opportunities for NMR studies on complex and largemolecular assemblies in life and material sciences. In suchapplicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3648e4a5394b03dc2dba0155f2e7c95f
https://pubmed.ncbi.nlm.nih.gov/26315337
https://pubmed.ncbi.nlm.nih.gov/26315337
Autor:
Charles Nicholson, Phillip E. Kunkler, Raymond E. Hulse, Richard P. Kraig, Michael W. Schmitt
Publikováno v:
The Journal of Neuroscience. 25:3952-3961
Spreading depression (SD) involves current flow through principal neurons, but the pattern of current flow over the expanse of susceptible tissues or individual principal neurons remains undefined. Accordingly, tissue and single cell maps made from d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f31db7ab2e9116d09461e95e3f86c8
https://doi.org/10.1523/jneurosci.0491-05.2005
https://doi.org/10.1523/jneurosci.0491-05.2005