Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function

Autor: Yachen Shen, Yvonne Su, Francisco J. Silva, Angela H. Weller, Jaimarie Sostre-Colón, Paul M. Titchenell, David J. Steger, Patrick Seale, Raymond E. Soccio

Publikováno v: Cell Reports, Vol 30, Iss 9, Pp 3079-3091.e5 (2020)

Summary: Brown adipose tissue (BAT) generates heat to maintain body temperature and suppress obesity. Agonists for nuclear receptors PPARα and PPARγ both affect brown adipocyte function, yet the interplay between these factors in BAT is uncertain.

Externí odkaz: https://doaj.org/article/d772bdc9050b4cbfbde414a046cf5106

ILRUN , a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice

Autor: Raymond E. Soccio, Nicholas J. Hand, Yachen Shen, John S. Millar, Paul C. Lee, Li Li, Takashi Kuwano, Xin Bi, Daniel J. Rader

Publikováno v: Circulation Research. 127:1347-1361

Rationale: Single-nucleotide polymorphisms near the ILRUN (inflammation and lipid regulator with ubiquitin-associated–like and NBR1 [next to BRCA1 gene 1 protein]-like domains) gene are genome-wide significantly associated with plasma lipid traits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7294127a22aa214dfc9cced7bb3ae2ad
https://doi.org/10.1161/circresaha.120.317175

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Autor: Seth McGonigle, Susanne Mandrup, Olivia Sveidahl Johansen, Laia Reverte-Salisa, Rudolf Zechner, Lasse K. Markussen, Thomas Nielsen, Eline N. Kuipers, Andreas Kjaer, Maria Razzoli, Alexander Pfeifer, Jakob Bondo Hansen, Cheryl Cero, Alessandro Bartolomucci, James G. Granneman, Brice Emanuelli, Raymond E. Soccio, Morten Lundh, Thue Walter Schwartz, Søren Nielsen, Wenfei Sun, Dan Ploug Christensen, Hua Dong, Christa Broholm, Thorsten Gnad, Nienke Willemsen, Camilla Scheele, William Orchard, Oksana Dmytriyeva, Iuliia Karavaeva, Patrick C.N. Rensen, Marie S. Isidor, Sander Kooijman, Niels Grarup, Mikkel Frost, Cecilie Mørch Hallgren, Davide Calebiro, Tao Ma, Naja Z. Jespersen, M. Madan Babu, Mikael Rydén, Shannon L. O'Brien, Carsten H. Nielsen, Renate Schreiber, Zachary Gerhart-Hines, Jacob B. Hansen, Jonas T. Treebak, Yachen Shen, Torben Hansen, Oluf Pedersen, Elahu G. Sustarsic

Publikováno v: Sveidahl Johansen, O, Ma, T, Hansen, J B, Markussen, L K, Schreiber, R, Reverte-Salisa, L, Dong, H, Christensen, D P, Sun, W, Gnad, T, Karavaeva, I, Nielsen, T S, Kooijman, S, Cero, C, Dmytriyeva, O, Shen, Y, Razzoli, M, O'Brien, S L, Kuipers, E N, Nielsen, C H, Orchard, W, Willemsen, N, Jespersen, N Z, Lundh, M, Sustarsic, E G, Hallgren, C M, Frost, M, McGonigle, S, Isidor, M S, Broholm, C, Pedersen, O, Hansen, J B, Grarup, N, Hansen, T, Kjær, A, Granneman, J G, Babu, M M, Calebiro, D, Nielsen, S, Rydén, M, Soccio, R, Rensen, P C N, Treebak, J T, Schwartz, T W, Emanuelli, B, Bartolomucci, A, Pfeifer, A, Zechner, R, Scheele, C, Mandrup, S & Gerhart-Hines, Z 2021, ' Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis ', Cell, vol. 184, no. 13, pp. 3502-3518 . https://doi.org/10.1016/j.cell.2021.04.037
Cell
Sveidahl Johansen, O, Ma, T, Hansen, J B, Markussen, L K, Schreiber, R, Reverte-Salisa, L, Dong, H, Christensen, D P, Sun, W, Gnad, T, Karavaeva, I, Nielsen, T S, Kooijman, S, Cero, C, Dmytriyeva, O, Shen, Y, Razzoli, M, O'Brien, S L, Kuipers, E N, Nielsen, C H, Orchard, W, Willemsen, N, Jespersen, N Z, Lundh, M, Sustarsic, E G, Hallgren, C M, Frost, M, McGonigle, S, Isidor, M S, Broholm, C, Pedersen, O, Hansen, J B, Grarup, N, Hansen, T, Kjær, A, Granneman, J G, Babu, M M, Calebiro, D, Nielsen, S, Rydén, M, Soccio, R, Rensen, P C N, Treebak, J T, Schwartz, T W, Emanuelli, B, Bartolomucci, A, Pfeifer, A, Zechner, R, Scheele, C, Mandrup, S & Gerhart-Hines, Z 2021, ' Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis ', Cell, vol. 184, no. 13, pp. 3502-3518 + . https://doi.org/10.1016/j.cell.2021.04.037
Cell, 184 (13)
Cell, 184(13), 3502-3518.e33. CELL PRESS
Nat Rev Endocrinol

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fad4327df6593d39587aa7ce062641
https://findresearcher.sdu.dk:8443/ws/files/184106202/PIIS0092867421005729.pdf

Pparγ1 Facilitates ErbB2-Mammary Adenocarcinoma in Mice

Autor: Lifeng Tian, Chenguang Wang, Wei Tong, Yichuan Liu, Anthony W. Ashton, Richard G. Pestell, Andrew V. Kossenkov, Adam Ertel, Raymond E. Soccio, Joanna Balcerek, Zhao Zhang, Xuanmao Jiao, Mathew C. Casimiro, Qin Liu, Eric Chen

Publikováno v: Cancers
Volume 13
Issue 9
Cancers, Vol 13, Iss 2171, p 2171 (2021)

Simple Summary HER2, which is associated with clinically aggressive disease, is overexpressed in 15–20% of breast cancers (BC). Peroxisome proliferator-activated receptor γ (PPARγ), is expressed in a variety of malignancies. The aim of our study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90cea1944e667ec4533d5b09db246b3

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice

Autor: Hee-Woong Lim, Zhenghui Li, Yee Hoon Foong, Kiara K. Benson, Jennifer F. Jolivert, Carlos J. Medina, Richard K. Dzeng, Megan Kissig, Matthew J. Emmett, Joanna R. DiSpirito, Mitchell A. Lazar, Lindsey C. Peed, Raymond E. Soccio, Patrick Seale, Erika R. Briggs, David J. Steger, Kyoung-Jae Won, Manashree Damle, Shannon E. Mullican, Satyajit R. Rajapurkar, Eric Chen

Publikováno v: Journal of Clinical Investigation. 127:1451-1462

Obesity causes insulin resistance, and PPARγ ligands such as rosiglitazone are insulin sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a high-fat diet (HFD) has major effects on visceral epididymal adipose ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc66ae25bf2d8b25622b561b69442de0
https://doi.org/10.1172/jci91211