Výsledky vyhledávání - "Raymond E Mdachi"

Akademický článek

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis.

Autor: John K Thuita, Kristina K Wolf, Grace A Murilla, Qiang Liu, James N Mutuku, Yao Chen, Arlene S Bridges, Raymond E Mdachi, Mohamed A Ismail, Shelley Ching, David W Boykin, James Edwin Hall, Richard R Tidwell, Mary F Paine, Reto Brun, Michael Zhuo Wang

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2230 (2013)

There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT. The development of

Externí odkaz: https://doaj.org/article/3329b3b038db4c1fbbbafc2be436adde

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Akademický článek

Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.

Autor: John K Thuita, Michael Z Wang, John M Kagira, Cathrine L Denton, Mary F Paine, Raymond E Mdachi, Grace A Murilla, Shelley Ching, David W Boykin, Richard R Tidwell, James E Hall, Reto Brun

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1734 (2012)

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second stage HAT, where parasites h

Externí odkaz: https://doaj.org/article/dba01f043eb542fabcb25c6cfc47a593

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Akademický článek

Spatial–Temporal Variations in Parasitological Prevalence and Host-Related Risk Factors of Camel Trypanosomiasis and Its Vectors in North Eastern Kenya: A Repeated Cross-Sectional Study

Autor: Kennedy O. Ogolla, Judith K. Chemuliti, Florence N. Wamwiri, Joanna E. Auma, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Raymond E. Mdachi, Phoebe W. Mukiria, Sylvance O. Okoth

Publikováno v: Journal of Parasitology Research, Vol 2023 (2023)

Camel trypanosomiasis (Surra) is endemic in the Horn of Africa. Understanding the spatiotemporal variations in Surra prevalence, vector dynamics, and host-related risk factors is important in developing effective control strategies. A repeated cross-

Externí odkaz: https://doaj.org/article/4913c205903343c3ab3075ee17f19127

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Abiotic transformations and decomposition kinetics of 4-carbamoyl-2'-[(hydroxyimino)methyl]-1,1'-(oxydimethylene)-bis(pyridin ium chloride) in aqueous phosphate buffers

Autor: Donald J. Ecobichon, Raymond E. Mdachi, Celso E. Connolley-Mendoza, F. M. Fouad, W. D. Marshall

Publikováno v: Chemical research in toxicology. 3(5)

The rate of disappearance of 4-carbamoyl-2'-[(hydroxyimino)methyl]-1,1'-(oxydimethylene) bis (pyridinium chloride) (HI-6) from aqueous phosphate buffers (pH 3.0-9.1) was both pH and temperature sensitive. In midrange buffers (pH 6.0-9.1, mu = 0.2 M)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e7edb5da68fc29427e5cf0e58ca53
https://pubmed.ncbi.nlm.nih.gov/2133092

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