Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Raymond D. Mosteller"'
Publikováno v:
Molecular and Cellular Biology. 18:7444-7454
The Ras-related GTPases are small, 20- to 25-kDa proteins which cycle between an inactive GDP-bound form and an active GTP-bound state. The Ras superfamily includes the Ras, Rho, Ran, Arf, and Rab/YPT1 families, each of which controls distinct cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a4c0e811e4111d298fc676a18638ba
https://doi.org/10.1128/mcb.18.12.7444
https://doi.org/10.1128/mcb.18.12.7444
Publikováno v:
Molecular and Cellular Biology. 14:8117-8122
Previously we found that negatively charged residues at positions 62, 63, and 69 of H-Ras are involved in binding to the CDC25 guanine nucleotide exchange factor (GEF). Using site-directed mutagenesis, we have changed conserved, positively charged re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f875238e6478238b530b10e611413a5
https://doi.org/10.1128/mcb.14.12.8117
https://doi.org/10.1128/mcb.14.12.8117
Publikováno v:
Molecular and Cellular Biology. 14:1104-1112
Ras proteins are activated in vivo by guanine nucleotide exchange factors encoded by genes homologous to the CDC25 gene of Saccharomyces cerevisiae. We have taken a combined genetic and biochemical approach to probe the sites on Ras proteins importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5468058be953b08af5627feabdf5e0
https://doi.org/10.1128/mcb.14.2.1104
https://doi.org/10.1128/mcb.14.2.1104
Autor:
Enrique Gonzales, Wen Wei, Chiranjib Dasgupta, Ben-Xian Liu, Daniel Broek, Peng Li, Denise M. McKinney, Pritha Sanyal, Raymond D. Mosteller
Publikováno v:
Proceedings of the National Academy of Sciences. 89:7100-7104
The yeast Saccharomyces cerevisiae CDC25 gene encodes a nucleotide-exchange-factor (NEF) that can convert the inactive GDP-bound state of RAS proteins to an active RAS-GTP complex. CDC25 can activate the yeast RAS proteins as well as the human H-ras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569b9ff7db61abd00cac883f6689b0aa
https://doi.org/10.1073/pnas.89.15.7100
https://doi.org/10.1073/pnas.89.15.7100
Autor:
Raymond D. Mosteller, U. Murali Krishna, Xiaodong Shu, Jaewon Han, Balaka Das, Michael A. White, John R. Falck, Katherine Luby-Phelps, Daniel Broek, Yi Xia
Publikováno v:
Science. 279:558-560
Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP)–guanosine triphosphate (GTP) exchange factor for Rac that stimulates the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a503a0446d52d12d5cdc01d25f9b55b8
https://doi.org/10.1126/science.279.5350.558
https://doi.org/10.1126/science.279.5350.558
Publikováno v:
Molecular and cellular biology. 24(17)
Lipopolysaccharide (LPS) signaling is critical for the innate immune response to gram-negative bacteria. Here, evidence is presented for LPS stimulation of sphingosine kinase (SPK) in the RAW 264.7 murine macrophage cell line and rat primary hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c733f5e5dc817283be287a21ad7e797c
https://pubmed.ncbi.nlm.nih.gov/15314148
https://pubmed.ncbi.nlm.nih.gov/15314148
Publikováno v:
Molecular and cellular biology. 22(22)
Vascular endothelial growth factor (VEGF) signaling is critical to the processes of angiogenesis and tumor growth. Here, evidence is presented for VEGF stimulation of sphingosine kinase (SPK) that affects not only endothelial cell signaling but also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1773a09814303fbaac3411f86e91eff
https://pubmed.ncbi.nlm.nih.gov/12391145
https://pubmed.ncbi.nlm.nih.gov/12391145
Publisher Summary This chapter discusses the biochemical analysis of regulation of Vav, a guanine-nucleotide exchange factor for Rho family of guanosine 5'-triphosphate (GTPase). Ras and Rac GTPases are activated by guanine-nucleotide exchange factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be97237979173d8e96209b568d6c63be
https://doi.org/10.1016/s0076-6879(00)25429-3
https://doi.org/10.1016/s0076-6879(00)25429-3
Autor:
Jaewon Han, Daniel Broek, Wen Wei, Channing J. Der, J K Westwick, Raymond D. Mosteller, Balaka Das, Roya Khosravi-Far, L. Van Aelst
Vav is a member of a family of oncogene proteins that share an approximately 250-amino-acid motif called a Dbl homology domain. Paradoxically, Dbl itself and other proteins containing a Dbl domain catalyze GTP-GDP exchange for Rho family proteins, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdab462e0e4de4ddcd6a3b9cdbee6d01
Autor:
Channing J. Der, Jonelle K. Drugan, Amy Lowry, Jaewon Han, Dan Broek, Sharon L. Campbell, Lawrence A. Quilliam, Raymond D. Mosteller, Mark M. Hisaka, Sheng Zhong
Publikováno v:
The Journal of biological chemistry. 271(19)
While Ras proteins are activated by stimulated GDP release, which enables acquisition of the active GTP-bound state, little is known about how guanine nucleotide exchange factors (GEFs) interact with Ras to promote this exchange reaction. Here we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924ebf736c62d2b7beff910ed72bc9d2
https://pubmed.ncbi.nlm.nih.gov/8626650
https://pubmed.ncbi.nlm.nih.gov/8626650