Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Raymond D. Gilbert"'
Publikováno v:
Journal of the Society for Gynecologic Investigation. 13:11-18
We have previously shown that after exposure to long-term hypoxia, fetal coronary flow is maintained at control levels despite a 25% reduction in cardiac output. We also demonstrated that coronary vascular rings isolated from the long-term hypoxic fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404c99c5730d3309e5faabbe33da4bbc
https://doi.org/10.1016/j.jsgi.2005.09.006
https://doi.org/10.1016/j.jsgi.2005.09.006
Publikováno v:
The Journal of Physiology. 565:149-158
The present study tested the hypothesis that prenatal cocaine exposure differentially regulates heart susceptibility to ischaemia-reperfusion (I/R) injury in adult offspring male and female rats. Pregnant rats were administered intraperitoneally eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e0e0433ef313c5f3e3936bb4ca0651f
https://doi.org/10.1113/jphysiol.2005.082701
https://doi.org/10.1113/jphysiol.2005.082701
Publikováno v:
Journal of the Society for Gynecologic Investigation. 10:265-274
Epidemiologic studies showed an association between adverse intrauterine environment and ischemic heart disease in the adult. We tested the hypothesis that prenatal hypoxia increased the susceptibility of adult heart to ischemia-reperfusion (I-R) inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2846c1df80a0f244dd0b671c3a9585
https://doi.org/10.1016/s1071-5576(03)00074-1
https://doi.org/10.1016/s1071-5576(03)00074-1
Publikováno v:
Journal of the Society for Gynecologic Investigation. 10:189-193
In fetal sheep, we found that the augmentation of cardiac contractility by beta-adrenergic receptor (beta-AR) stimulation was reduced after exposure to long-term hypoxia. However, cyclic adenosine monophosphate (cAMP) production after beta-AR stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5fdae807a29e0af4d1ade4173d18e5
https://doi.org/10.1016/s1071-5576(03)00042-x
https://doi.org/10.1016/s1071-5576(03)00042-x
Publikováno v:
Journal of the Society for Gynecologic Investigation. 9:335-341
We studied the effect of long-term, high-altitude hypoxia on cardiac myosin, actin, and troponin T (TnT) isoforms and Ca2+ and Mg2+-activated myofibrillar adenosine triphosphatase (ATPase) activities in fetal and adult sheep. We exposed pregnant (beg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c80a08ed269eddf62d31f8e24e4956
https://doi.org/10.1177/107155760200900603
https://doi.org/10.1177/107155760200900603
Publikováno v:
Journal of the Society for Gynecologic Investigation. 7:211-217
To examine the effects of long-term high-altitude hypoxia on the contractile properties of isolated fetal coronary arteries. Maximal contractile responses (Tmax) to 90 mmol/L KCl and the thromboxane A2 mimetic U46619 were measured in proximal (PLCx)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409405fc2242ae508b9f22c2ecface00
https://doi.org/10.1177/107155760000700404
https://doi.org/10.1177/107155760000700404
Publikováno v:
The Anatomical Record. 256:381-388
In order to determine the effects of chronic, high-altitude hypoxia on the ovine fetal heart, we exposed pregnant ewes to 3,820 m beginning at 30 days gestation. We previously showed that following approximately 110 days of hypoxia the fetal heart sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::519b0bf35300b0d19923d8340f267b19
https://doi.org/10.1002/(sici)1097-0185(19991201)256:4<381::aid-ar5>3.0.co
https://doi.org/10.1002/(sici)1097-0185(19991201)256:4<381::aid-ar5>3.0.co
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 277:H756-H762
To determine the effect of chronic hypoxia on myocardial capillarity, we exposed pregnant ewes to an altitude of 3,820 m from day 30 to day 139 of gestation and compared the fetus to low-altitude (approximately 300 m) controls. We hypothesized that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca5bc82f2849aabb3cc6a98c50fbfa6
https://doi.org/10.1152/ajpheart.1999.277.2.h756
https://doi.org/10.1152/ajpheart.1999.277.2.h756
Autor:
Raymond D. Gilbert
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 119:669-674
In fetal sheep subjected to high altitude hypoxemia for 110 days beginning on day 30 of gestation, cardiac output was decreased 24% compared to normoxic control fetuses. This decrease was due to a 33% reduction in right ventricular output, with only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a7dd3e48c59b8c4529e4da78dc769c
https://doi.org/10.1016/s1095-6433(98)01003-4
https://doi.org/10.1016/s1095-6433(98)01003-4
Autor:
Raymond D. Gilbert, William J. Pearce, Vaughn A. Browne, Lawrence D. Longo, Virginia M. Stiffel
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 273:R2022-R2031
In this study, we hypothesized that a reduction in β-adrenergic receptor number or a decrease in functional coupling of the receptor to the adenylate cyclase system may be responsible for the blunted inotropic response to isoproterenol observed in f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bdef3a02bd17ab36b4c11d43d9d907
https://doi.org/10.1152/ajpregu.1997.273.6.r2022
https://doi.org/10.1152/ajpregu.1997.273.6.r2022