Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Raymond C. Wadlow"'
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Akademický článek
Concurrent BRAFV600E and BRCA Mutations in MSS Metastatic Colorectal Cancer: Prevalence and Case Series of mCRC patients with prolonged OS
Autor: Timothy Lewis Cannon, MD., Jamie N Randall, BA., Ethan S. Sokol, PhD., Sonja M. Alexander, Raymond C. Wadlow, MD., Arthur A. Winer, MD., Daniel M. Barnett, MD., Danny L. Rayes, BS., Halla S. Nimeiri, MD., Kimberly A. McGregor, MD
Publikováno v: Cancer Treatment and Research Communications, Vol 32, Iss , Pp 100569- (2022)
Background: BRAF V600E+ microsatellite stable (MSS) metastatic colorectal cancer (mCRC) patients comprise up to 10% of advanced CRC. They have a poor prognosis with a median survival typically
Externí odkaz: https://doaj.org/article/3ab8acbc44624609a039fddd60b6bb6e
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2
Molecular Pathogenesis of Cholangiocarcinoma: Implications for Disease Classification and Therapy
Autor: Khaled W, Kabbara, Timothy, Cannon, Arthur, Winer, Raymond C, Wadlow
Publikováno v: Oncology (Williston Park, N.Y.). 36(8)
Cholangiocarcinomas are an aggressive group of heterogeneous malignancies that affect over 210,000 individuals globally each year. Their incidence is rising, particularly in Western countries. Traditionally, cholangiocarcinomas are classified based o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7274dc8138936c156710928047cd3d97
https://pubmed.ncbi.nlm.nih.gov/36001788
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3
A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer
Autor: Brian M. Wolpin, Jennifer A. Chan, Raymond C. Wadlow, Kimmie Ng, Amanda Carpenter, Lipika Goyal, Thomas A. Abrams, Rebecca S. Heist, Deborah Schrag, Eunice L. Kwak, Jeffrey W. Clark, Surendra Pal Chaudhary, David P. Ryan, Wolfram Goessling, Peter C. Enzinger, Nadine Jackson McCleary, Jill N. Allen
Publikováno v: Investigational New Drugs. 38:1533-1539
Subsets of esophagogastric (EG) cancers harbor genetic abnormalities, including amplification of HER2, MET, or FGFR2 or mutations in PIK3CA, EGFR, or BRAF. Ganetespib which is a novel triazolone heterocyclic inhibitor of HSP90, is a potentially biolo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5878a697b5f3396a3e575273783821f6
https://doi.org/10.1007/s10637-019-00889-y
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4
A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma
Autor: Alexander Rosemury, Robert A. Newman, Jordan Berlin, Vincent J. Picozzi, Raymond C. Wadlow, Marc T. Roth, Margaux Steinbach, Erkut Borazanci, Dana Backlund Cardin
Publikováno v: Oncologist
Lessons Learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the most common si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a45be6080c9ff7504d2ee942975514
https://pubmed.ncbi.nlm.nih.gov/32452588
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5
Capecitabine and oxaliplatin as first and second line treatment for locally advanced and metastatic pancreatic ductal adenocarcinoma
Autor: Keith Stuart, Susanna Jacobus, Thomas A. Abrams, Michael Goldstein, Rebecca A. Miksad, Raymond C. Wadlow, Andrea J. Bullock
Publikováno v: Journal of Gastrointestinal Oncology. 8:945-952
Background: There are limited treatment options available for patients with advanced pancreatic ductal adenocarcinoma (PDAC). We conducted a phase II study evaluating the efficacy and safety of capecitabine/oxaliplatin (CAPOX) in patients with locall
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076f0c7b7d9076cb06c4e4b8dd65c7c4
https://doi.org/10.21037/jgo.2017.06.06
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6
Akademický článek
Systems-level modeling of cancer-fibroblast interaction.
Autor: Raymond C Wadlow, Ben S Wittner, S Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy
Publikováno v: PLoS ONE, Vol 4, Iss 9, p e6888 (2009)
Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies to target cancer stroma.
Externí odkaz: https://doaj.org/article/1d7e01f1bf294bd48c986682c0d204a1
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9
Targetable mutations in gastrointestinal malignancies: A comparison of RAS mutant and RAS wild type tumors
Autor: Dan Barnett, Jamie Randall, Sarah Mullaly, Gail Payne, Erica Marchlik, Sheryl Krevsky Elkin, Danny Rayes, Hongkun Wang, Raymond C. Wadlow, Lindsey Tishman, Timothy L. Cannon
Publikováno v: Journal of Clinical Oncology. 39:129-129
129 Background: KRAS and NRAS (RAS) mutations are considered driver mutations in gastrointestinal malignancies such as colorectal and pancreatic cancer. Our institution obtains broad molecular testing (commercial panels with full exon coverage of at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9efe756b61a0ee4206ca4ad621b3b26b
https://doi.org/10.1200/jco.2021.39.3_suppl.129
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10
Phase II clinical trial of novel agent PBI-05204 in patients with metastatic pancreatic adenocarcinoma (mPDA)
Autor: Marc T. Roth, Raymond C. Wadlow, Vincent J. Picozzi, Alexander S. Rosemurgy, Margaux Steinbach, Robert A. Newman, Erkut Borazanci, Dana Backlund Cardin, Jordan Berlin
Publikováno v: Journal of Clinical Oncology. 38:698-698
698 Background: Survival statistics for mPDA are dismal and with limited treatment options novel agents are needed to improve disease outcomes. PBI-05204 (Phoenix Biotechnology, Inc., San Antonio, TX) is a modified supercritical carbon dioxide extrac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63c251122ed13878d3e08093e0a3b038
https://doi.org/10.1200/jco.2020.38.4_suppl.698
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