Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Raymond C. Chang"'
Publikováno v:
Synapse. 61:540-546
Sigma-1 receptors are widely expressed in the mammalian brain and also in organs of the immune, endocrine and reproductive systems. Based on behavioral and pharmacological assessments, sigma-1 receptors are important in memory and cognitive processes
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:547-555
The novel sigma-1 receptor PET radiotracer [18F]1-(2-fluoroethyl)-4-[(4-cyanophenoxy)methyl]piperidine ([18F]WLS1.002, [18F]-2) was synthesized (n=6) by heating the corresponding N-ethylmesylate precursor in an anhydrous acetonitrile solution contain
Publikováno v:
The Quarterly Journal of Experimental Psychology: Section B. 57:1-23
Three Pavlovian lick suppression studies with rats were conducted to compare the role of the conditioning context in excitatory backward and forward conditioning. The experiments explored the possibility that excitatory backward conditioning, but not
Publikováno v:
Learning and Motivation. 34:68-86
Two experiments with rats as subjects investigated whether massive extinction can attenuate the renewal effect. Experiment 1 investigated whether moderate or massive extinction could prevent the return of conditioned responding following Pavlovian co
Autor:
Jun Zhao, Michael G. Stabin, Raymond C. Chang, Hanna Ng, Rikki N. Waterhouse, Janice Schindler-Horvat, Jon C. Mirsalis
Publikováno v:
Molecular imaging and biology. 8(5)
[(18)F]1-(2-Fluoroethyl)-4-[(4-cyanophenoxy)methyl]piperidine ([(18)F]SFE) is a novel, selective, high-affinity sigma-1 receptor radioligand that has been preclinically well characterized in rodents. To support an investigational new drug (IND) appli
Publikováno v:
Learningbehavior. 31(4)
Latent inhibition, which refers to attenuated responding to a conditioned stimulus (CS) after CS-unconditioned stimulus (CS-US) pairings as a result of CS-alone presentations prior to the pairings, is often attenuated if preexposure and conditioning
Publikováno v:
Journal of experimental psychology. Animal behavior processes. 29(3)
The information acquired in backward conditioning (i.e., outcome3 cue) was assessed in 3 Pavlovian lick-suppression experiments with water-deprived rats as subjects. Experiment 1 confirmed previous research that few outcome 3 cue pairings made the cu
Autor:
Abida Sultana, Jun Zhao, Filip Dumont, Rikki N. Waterhouse, Mark Slifstein, Raymond C. Chang, Andrew Balter, Yasuhiko Sudo, Marc Laruelle
Publikováno v:
Nuclear medicine and biology. 31(7)
The development of imaging methods to measure changes in NMDA ion channel activation would provide a powerful means to probe the mechanisms of drugs and device based treatments (e.g., ECT) thought to alter glutamate neurotransmission. To provide a po