Zobrazeno 1 - 10
of 514
pro vyhledávání: '"Raymond C Stevens"'
Autor:
Angdi Li, Shuning Zhang, Valentina Loconte, Yan Liu, Axel Ekman, Garth J Thompson, Andrej Sali, Raymond C Stevens, Kate White, Jitin Singla, Liping Sun
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0269887 (2022)
Investigating the 3D structures and rearrangements of organelles within a single cell is critical for better characterizing cellular function. Imaging approaches such as soft X-ray tomography have been widely applied to reveal a complex subcellular o
Externí odkaz:
https://doaj.org/article/e34d3f3d819d4259b41e890b26737c8f
Autor:
Angdi Li, Xiangyi Zhang, Jitin Singla, Kate White, Valentina Loconte, Chuanyang Hu, Chuyu Zhang, Shuailin Li, Weimin Li, John Paul Francis, Chenxi Wang, Andrej Sali, Liping Sun, Xuming He, Raymond C Stevens
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265567 (2022)
The mesoscale description of the subcellular organization informs about cellular mechanisms in disease state. However, applications of soft X-ray tomography (SXT), an important approach for characterizing organelle organization, are limited by labor-
Externí odkaz:
https://doaj.org/article/b8c3d33fcaab493b8e80034aa55d9c95
Autor:
Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dan-Dan Shen, Yan Zhang, Tian Xia, Raymond C Stevens, H Eric Xu, Dehua Yang, Lihua Zhao, Ming-Wei Wang
Publikováno v:
eLife, Vol 10 (2021)
Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that exerts crucial metabolic functions by binding and activating its cognate receptor, GIPR. As an important therapeutic target, GIPR has been subjected to intensive structural
Externí odkaz:
https://doaj.org/article/0967668657d1439e96bdc203b0e58d6e
Autor:
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wanjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Wonjo Jang, Eugene I Shakhnovich, Zhi-Jie Liu, Raymond C Stevens, Nevin A Lambert, M Madan Babu, Ming-Wei Wang, Suwen Zhao
Publikováno v:
eLife, Vol 8 (2019)
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for discovering novel therapeutics since about one-third of all marketed drugs target members of
Externí odkaz:
https://doaj.org/article/1fd7d071b55047e5a53a68b7fcb67b21
Autor:
Petr Popov, Yao Peng, Ling Shen, Raymond C Stevens, Vadim Cherezov, Zhi-Jie Liu, Vsevolod Katritch
Publikováno v:
eLife, Vol 7 (2018)
Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational ap
Externí odkaz:
https://doaj.org/article/b8940c7a6e0345e6acf1ba771959fe13
Autor:
Yi-Fan Zeng, Ke-Xin Yang, Yilong Cui, Xiao-Na Zhu, Rui Li, Hanqing Zhang, Dong Chuan Wu, Raymond C. Stevens, Ji Hu, Ning Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The hippocampus creates a cognitive map of the external environment by encoding spatial and self-motion-related information. However, it is unclear whether hippocampal neurons could also incorporate internal cognitive states reflecting an an
Externí odkaz:
https://doaj.org/article/ace06b99089f46b1967084159b18e267
Autor:
Weimin Li, Angdi Li, Bing Yu, Xiaoxiao Zhang, Xiaoyan Liu, Kate L. White, Raymond C. Stevens, Wolfgang Baumeister, Andrej Sali, Marion Jasnin, Liping Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Actin mediates insulin secretion in pancreatic β-cells through remodeling. Hampered by limited resolution, previous studies have offered an ambiguous depiction as depolymerization and repolymerization. We report the in situ structure of act
Externí odkaz:
https://doaj.org/article/d721548ce6ab4d77b7809b9ae04ac75d
Autor:
Birgitte P S Jacky, Patton E Garay, Jérôme Dupuy, Jeremy B Nelson, Brian Cai, Yanira Molina, Joanne Wang, Lance E Steward, Ron S Broide, Joseph Francis, K Roger Aoki, Raymond C Stevens, Ester Fernández-Salas
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003369 (2013)
Botulinum neurotoxin serotype A (BoNT/A) causes transient muscle paralysis by entering motor nerve terminals (MNTs) where it cleaves the SNARE protein Synaptosomal-associated protein 25 (SNAP25206) to yield SNAP25197. Cleavage of SNAP25 results in bl
Externí odkaz:
https://doaj.org/article/0af89e3fbf6f4f00b8e336144aea2833
Publikováno v:
PLoS Pathogens, Vol 4, Iss 8, p e1000129 (2008)
Botulinum neurotoxins have a very high affinity and specificity for their target cells requiring two different co-receptors located on the neuronal cell surface. Different toxin serotypes have different protein receptors; yet, most share a common gan
Externí odkaz:
https://doaj.org/article/cc26cd65e05f464fa41c8b2d574914c4
Autor:
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F. DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C. Stevens, Wei Peng, Bryan L. Roth, Zihe Rao, Zhi-Jie Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-Gi complex with the agonist MK-6892 and inactive state crystal structures of muta
Externí odkaz:
https://doaj.org/article/f2f56268a33144af8505eff4c3edac34