Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Raymond A. Chavez"'
Autor:
Tracey A Larson, Madison A. Clements, Raymond A. Chavez, Eric H. Mitten, Anouk E.W. Schrama, Kevin M. Harris, Anne Marie van Dam, Kenner C. Rice, Steven F. Maier, Hardik P. Patel, Linda R. Watkins, Scott T. Litwiler, Lewis O. Harvey, Laurel S. Todd, Suzanne M. Green Fulgham, Julissa Chante Duran-Malle, Andrew J. Kwilasz
Publikováno v:
Kwilasz, A J, Green Fulgham, S M, Duran-Malle, J C, Schrama, A E W, Mitten, E H, Todd, L S, Patel, H P, Larson, T A, Clements, M A, Harris, K M, Litwiler, S T, Harvey, L O, Maier, S F, Chavez, R A, Rice, K C, Van Dam, A M & Watkins, L R 2021, ' Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain ', Brain, Behavior, and Immunity, vol. 93, pp. 80-95 . https://doi.org/10.1016/j.bbi.2020.12.016
Brain, Behavior, and Immunity, 93, 80-95. Academic Press Inc.
Brain Behav Immun
Brain, Behavior, and Immunity, 93, 80-95. Academic Press Inc.
Brain Behav Immun
Neuropathic pain is a major symptom of multiple sclerosis (MS) with up to 92% of patients reporting bodily pain, and 85% reporting pain severe enough to cause functional disability. None of the available therapeutics target MS pain. Toll-like recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4354c0d59ac1e9d7b28840c46c85223c
https://research.vumc.nl/en/publications/51209ccd-425c-4a7a-affd-cfd47908c230
https://research.vumc.nl/en/publications/51209ccd-425c-4a7a-affd-cfd47908c230
Autor:
Suzanne M. Green-Fulgham, Megan Fry, Robert Landry, Collins Stephen, Raymond A. Chavez, David K. Glover, John Forsayeth, Jonathan D. Coulson, Jayson M. Rieger, Linda R. Watkins
Publikováno v:
Brain, behavior, and immunity. 90
Osteoarthritis results in chronic pain and loss of function. Proinflammatory cytokines create both osteoarthritis pathology and pain. Current treatments are poorly effective, have significant side effects, and have not targeted the cytokines central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b3a0c0b37be82219d124a51424820d
https://pubmed.ncbi.nlm.nih.gov/32800926
https://pubmed.ncbi.nlm.nih.gov/32800926
Autor:
Steven F. Maier, Melissa J. Mahoney, Anne Marie van Dam, Peter M. Grace, John P. Christianson, Linda R. Watkins, Kathryn R. Penzkover, Raymond A. Chavez, Johanna G. Flyer-Adams, Keith A. Strand, John Forsayeth, Lisa C. Loram
Publikováno v:
Grace, P M, Loram, L C, Christianson, J P, Strand, K A, Flyer-Adams, J G, Penzkover, K R, Forsayeth, J R, van Dam, A M, Mahoney, M J, Maier, S F, Chavez, R A & Watkins, L R 2017, ' Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy ', Brain, Behavior, and Immunity, vol. 59, pp. 49-54 . https://doi.org/10.1016/j.bbi.2016.05.012
Brain, Behavior, and Immunity, 59, 49-54. Academic Press Inc.
Brain, Behavior, and Immunity, 59, 49-54. Academic Press Inc.
Relapsing-remitting multiple sclerosis is commonly associated with motor impairments, neuropathic pain, fatigue, mood disorders, and decreased life expectancy. However, preclinical pharmacological studies predominantly rely on clinical scoring of mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbe7217fa85fb3f070e01af6fbcb206
https://escholarship.org/uc/item/9zz0h3pk
https://escholarship.org/uc/item/9zz0h3pk
Autor:
Kirk W. Johnson, Annemarie Ledeboer, Steven F. Maier, Erin D. Milligan, Linda R. Watkins, Raymond A. Chavez, Leslie A. Leinwand, W Seibert, Evan M. Sloane, Benjamen D. Coats, A.M. Van Dam, M van Strien
Publikováno v:
Brain Behavior and Immunity, 23(1), 92-100. Academic Press Inc.
Sloane, E, Ledeboer, A, Seibert, W, Coats, B, van Strien, M, Maier, S F, Johnson, K W, Chavez, R, Watkins, L R, Leinwand, L, Milligan, E D & Van Dam, A M 2009, ' Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis : MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy ', Brain Behavior and Immunity, vol. 23, no. 1, pp. 92-100 . https://doi.org/10.1016/j.bbi.2008.09.004
Sloane, E, Ledeboer, A, Seibert, W, Coats, B, van Strien, M, Maier, S F, Johnson, K W, Chavez, R, Watkins, L R, Leinwand, L, Milligan, E D & Van Dam, A M 2009, ' Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis : MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy ', Brain Behavior and Immunity, vol. 23, no. 1, pp. 92-100 . https://doi.org/10.1016/j.bbi.2008.09.004
Multiple Sclerosis (MS) is an autoimmune inflammatory disease that presents clinically with a range of symptoms including motor, sensory, and cognitive dysfunction as well as demyelination and lesion formation in brain and spinal cord. A variety of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64858d2b08e625d97e036fe82e631e77
https://doi.org/10.1016/j.bbi.2008.09.004
https://doi.org/10.1016/j.bbi.2008.09.004
Autor:
Kirk W. Johnson, Erin D. Milligan, Stephen J. Langer, Leslie A. Leinwand, Linda R. Watkins, Travis S. Hughes, Raymond A. Chavez
Publikováno v:
Molecular Therapy. 17(1):88-94
Therapeutic benefit has been reported to result from intrathecal (i.t.) injection of transgene vectors, including naked DNA. However, most studies using naked DNA have measured only the transgene expression of intracellular proteins. Here we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9925a0f8c7f911999e1ab6e72a067f89
Autor:
Erin D. Milligan, Stephen J. Langer, Leslie A. Leinwand, David Martin, Evan M. Sloane, Kirk W. Johnson, Brian M. Jekich, Raymond A. Chavez, Linda R. Watkins, Steven F. Maier, John H. Mahoney, Annemarie Ledeboer
Publikováno v:
Brain, Behavior, and Immunity. 21:686-698
Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are poorly understood. Growing evidence supports that proinflammatory cytokines, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45673d95cc76ec638d5d6b752d703ea
https://doi.org/10.1016/j.bbi.2006.10.012
https://doi.org/10.1016/j.bbi.2006.10.012
Autor:
Angie Wadsworth, Lany Ruslim, Bhushan Samant, Dennis S. Hom, Linda Chen, Hongbing Zhang, Juri Y Fukuda, Mei-Chuan Ko, Anna Liao, Stellanie Simmonds, Karla P. Zeitz, Wes Zmolek, Raymond A. Chavez, Michael P. Bova, Balazs G. Szoke, Mark Dreyer, Albert W. Garofalo, Annika B. Malmberg, Eduardo R. Butelman, Ryan Holcomb, Jon E. Hawkinson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:619-630
The bradykinin B(1) receptor plays a critical role in chronic pain and inflammation, although efforts to demonstrate efficacy of receptor antagonists have been hampered by species-dependent potency differences, metabolic instability, and low oral exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd5c128d96318ca657dbc995c3d83a7
https://doi.org/10.1124/jpet.107.120352
https://doi.org/10.1124/jpet.107.120352
Autor:
John H. Mahoney, Matthew G. Frank, Steven F. Maier, Evan M. Sloane, Terence R. Flotte, Kirk W. Johnson, Melissa M. Mahoney, Raymond A. Chavez, Lindsay H. Levkoff, Leslie A. Leinwand, Linda R. Watkins, Travis S. Hughes, Pedro E. Cruz, Erin D. Milligan, Stephen J. Langer, Brian M. Jekich
Publikováno v:
Pain. 126:294-308
Neuropathic pain is a major clinical problem unresolved by available therapeutics. Spinal cord glia play a pivotal role in neuropathic pain, via the release of proinflammatory cytokines. Anti-inflammatory cytokines, like interleukin-10 (IL-10), suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2561eedcf0930a12a8beb6a55a9dc54
https://doi.org/10.1016/j.pain.2006.07.009
https://doi.org/10.1016/j.pain.2006.07.009
Autor:
Kirk W. Johnson, Ryan G. Soderquist, Melissa J. Mahoney, Linda R. Watkins, Raymond A. Chavez, Erin D. Milligan, Jacqueline A. Harrison
Publikováno v:
Journal of biomedical materials research. Part A. 93(3)
The anti-inflammatory cytokine interleukin-10 (IL-10) shows promise for the treatment of neuropathic pain, but for IL-10 to be clinically useful as a short-term therapeutic its duration needs to be improved. In this study, IL-10 was covalently modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51a3d95fa365e765be37bdd134d3f52
https://pubmed.ncbi.nlm.nih.gov/19768789
https://pubmed.ncbi.nlm.nih.gov/19768789
Autor:
Leslie A. Leinwand, Travis S. Hughes, Erin D. Milligan, Stephen J. Langer, Raymond A. Chavez, Linda R. Watkins, Salla I. Virtanen
Publikováno v:
The journal of gene medicine. 11(9)
One method for the delivery of therapeutic proteins to the spinal cord is to inject nonviral gene vectors including plasmid DNA into the cerebrospinal fluid (CSF) that surrounds the spinal cord (intrathecal space). This approach has produced therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86aa46211775018da0801d62f86c1e7
https://pubmed.ncbi.nlm.nih.gov/19533588
https://pubmed.ncbi.nlm.nih.gov/19533588