Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Raymond A. Sobel"'
Autor:
Meghna Sur, Mahima T. Rasquinha, Kiruthiga Mone, Chandirasegaran Massilamany, Ninaad Lasrado, Channabasavaiah Gurumurthy, Raymond A. Sobel, Jay Reddy
Publikováno v:
Cells, Vol 13, Iss 3, p 234 (2024)
Myocarditis is one of the major causes of heart failure in children and young adults and can lead to dilated cardiomyopathy. Lymphocytic myocarditis could result from autoreactive CD4+ and CD8+ T cells, but defining antigen specificity in disease pat
Externí odkaz:
https://doaj.org/article/cbc4dab3510b4fae8dce989e428548d5
Autor:
Mahima T. Rasquinha, Ninaad Lasrado, Meghna Sur, Kiruthiga Mone, Haowen Qiu, Jean-Jack Riethoven, Raymond A. Sobel, Jay Reddy
Publikováno v:
Vaccines, Vol 11, Iss 1, p 76 (2022)
Enteroviruses, which include Coxsackieviruses, are a common cause of virus infections in humans, and multiple serotypes of the group B Coxsackievirus (CVB) can induce similar diseases. No vaccines are currently available to prevent CVB infections bec
Externí odkaz:
https://doaj.org/article/6812fe3305e940d39d68f7fa22a165e2
Autor:
Raymond A Sobel, Megan Albertelli, Julian R Hinojoza, Mary Jane Eaton, Kevin V Grimes, Edward Rubenstein
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 81:414-433
The naturally occurring imino acid azetidine-2-carboxylic acid (Aze) is consumed by humans and can be misincorporated in place of proline in myelin basic protein (MBP) in vitro. To determine Aze effects on the mammalian CNS in vivo, adult CD1 mice we
Autor:
Ruihan Tang, Nandini Acharya, Ayshwarya Subramanian, Vinee Purohit, Marcin Tabaka, Yu Hou, Danyang He, Karen O. Dixon, Connor Lambden, Junrong Xia, Orit Rozenblatt-Rosen, Raymond A. Sobel, Chao Wang, Aviv Regev, Ana C. Anderson, Vijay K. Kuchroo
Publikováno v:
Sci Immunol
Dendritic cells (DCs) sense environmental cues and adopt either an immune-stimulatory or regulatory phenotype, thereby fine-tuning immune responses. Identifying endogenous regulators that determine DC function can thus inform the development of thera
Publikováno v:
Multiple sclerosis and related disorders. 68
Unresolved inflammation in multiple sclerosis (MS) is associated with progressive demyelination and symptom worsening. In the brain, both inflammation and resolution pathways are mediated by free lipid mediators (i.e., oxylipins) that can be derived
Autor:
Yoon-Chul Kye, Lloyd Bod, Arlene H. Sharpe, Raymond A. Sobel, Orit Rozenblatt-Rosen, Nir Yosef, Chao Wang, Allon Wagner, Vijay K. Kuchroo, Monika S. Kowalczyk, Francisco J. Quintana, Waradon Sungnak, Aviv Regev, Peter T. Sage
Publikováno v:
J Immunol
T follicular regulatory (TFR) cells limit Ab responses, but the underlying mechanisms remain largely unknown. In this study, we identify Fgl2 as a soluble TFR cell effector molecule through single-cell gene expression profiling. Highly expressed by T
Autor:
Sasha Gupta, Milos Simic, Sharon A. Sagan, Chanelle Shepherd, Jason Duecker, Raymond A. Sobel, Ravi Dandekar, Gregory F. Wu, Wesley Wu, John E. Pak, Stephen L. Hauser, Wendell Lim, Michael R. Wilson, Scott S. Zamvil
Publikováno v:
Neurology - Neuroimmunology Neuroinflammation. 10:e200080
Background and ObjectivesAnti-CD20 monoclonal antibody (mAb) B-cell depletion is a remarkably successful multiple sclerosis (MS) treatment. Chimeric antigen receptor (CAR)-T cells, which target antigens in a non-major histocompatibility complex (MHC)
Autor:
Kerry A. Pierce, Manoocher Soleimani, David DeTomaso, Lloyd Bod, Julian Avila-Pacheco, Elliot Akama-Garren, Brandon Schellhaass, Nir Yosef, Vasundhara Singh, Pratiksha I. Thakore, Allon Wagner, Sarah Zaghouani, Clary B. Clish, Raymond A. Sobel, James Kaminski, Alexandra Schnell, Erika L. Pearce, Chao Wang, Johannes Fessler, Daniel J. Puleston, Aviv Regev, Vijay K. Kuchroo, Elena Christian, Noga Ron-Harel, Vivian Paraskevi Douglas, Marcia C. Haigis
Publikováno v:
Cell
Cell, vol 184, iss 16
Cell, vol 184, iss 16
Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a516f7d904eb1d13dfbea99d5d9100ca
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Using a panel of monoclonal antibodies (mAbs) to myelin proteolipid protein (PLP) peptides, we found that in addition to CNS myelin, mAbs to external face but not cytoplasmic face epitopes immunostained neurons in immature human CNS tissues and in ad
Publikováno v:
Am J Physiol Endocrinol Metab
Long-chain acyl-CoA synthetase 4 (ACSL4) has a unique substrate specificity for arachidonic acid. Hepatic ACSL4 is coregulated with the phospholipid (PL)-remodeling enzyme lysophosphatidylcholine (LPC) acyltransferase 3 by peroxisome proliferator-act