Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Raymond A Koski"'
Autor:
Sukanya Narasimhan, Oriana Perez, Sara Mootien, Kathleen DePonte, Raymond A Koski, Erol Fikrig, Michel Ledizet
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68012 (2013)
Ixodes scapularis, the black-legged tick, vectors several human pathogens including Borrelia burgdorferi, the agent of Lyme disease in North America. Pathogen transmission to the vertebrate host occurs when infected ticks feed on the mammalian host t
Externí odkaz:
https://doaj.org/article/35b829a70eb547e1b0acafdd06582523
Autor:
Karen G Anthony, Ulrich Strych, Kacheong R Yeung, Carolyn S Shoen, Oriana Perez, Kurt L Krause, Michael H Cynamon, Paul A Aristoff, Raymond A Koski
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20374 (2011)
In an effort to discover new drugs to treat tuberculosis (TB) we chose alanine racemase as the target of our drug discovery efforts. In Mycobacterium tuberculosis, the causative agent of TB, alanine racemase plays an essential role in cell wall synth
Externí odkaz:
https://doaj.org/article/3e4a604a5b604dce8355e6a8c3ab559e
Autor:
Elizabeth Peterson-Roth, Harry Ostrer, Kayla Collado, Richard G. Stock, Sarah L. Kerns, Martin Mattessich, Michael A. Diefenbach, Raymond A. Koski, Barry S. Rosenstein, Paul Kaplan
Publikováno v:
Advances in Radiation Oncology, Vol 5, Iss 5, Pp 897-904 (2020)
Advances in Radiation Oncology
Advances in Radiation Oncology
Purpose A genetic test predicting susceptibility for the development of toxicities after prostate cancer radiation therapy is in development. This test intends to help physicians with treatment decision making. Methods and Materials Radiation oncolog
Autor:
Mark J. Mamula, Elizabeth Peterson-Roth, Stuart C. Helfand, Carmen J. Booth, Rita Ho, Raymond A. Koski, Renelle J. Gee, Tyler Masters, Deborah Bascombe, Dorothy Jackson, Hester A. Doyle, Christian R. Gee, Gerald R. Post, Lauren Price
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101205-(2021)
Translational Oncology
Translational Oncology
Highlights • Spontaneous dog cancers closely resemble human cancer. • Dogs with EGFR associated tumors were immunized with an EGFR/HER2 peptide vaccine. • EGFR peptide vaccinated dogs developed anti-EGFR/HER2 antibodies. • Vaccinated dogs hav
Autor:
Mark J. Mamula, Nathalie Bonafé, Raymond A. Koski, Renelle J. Gee, Stephanie M Tagliatela, Hester A. Doyle, Ross A Bruck
Publikováno v:
Cancer Immunol Immunother
Current treatments for tumors expressing epidermal growth factor receptor (EGFR) include anti-EGFR monoclonal antibodies, often used in conjunction with the standard chemotherapy, radiation therapy, or other EGFR inhibitors. While monoclonal antibody
Autor:
Pier F. Cirillo, Michel Ledizet, Sara Mootien, Peter Hegan, Raymond A. Koski, Oluwatoyin A. Asojo, Elizabeth Peterson-Roth, Yashang Lee, Uday Khire, Alan G Sutherland, Karen Anthony
Publikováno v:
ACS Med Chem Lett
[Image: see text] Human Macrophage Migration Inhibitory Factor (MIF) is a trimeric cytokine implicated in a number of inflammatory and autoimmune diseases and cancer. We previously reported that the dye p425 (Chicago Sky Blue), which bound MIF at the
Autor:
Monica M. Matsumoto, Michel Ledizet, Wanderson C. Rezende, Sarah K. Nelson, Alan Kelleher, Raymond A. Koski, Yashang Lee, Scott Reiling, Daniel A. Hyman, Sara Mootien, Karen Anthony, Oluwatoyin A. Asojo
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
Structures of C. difficile alanine racemase in complex with the PLP cofactor and cycloserine are presented.
Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among hospitalized
Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among hospitalized
Autor:
Michel Ledizet, Karen Anthony, Michael H. Cynamon, Sara Mootien, Paul Kaplan, Michelle S. DeStefano, Kacheong R. Yeung, Oluwatoyin A. Asojo, Carolyn Shoen, Paul A. Aristoff, Raymond A. Koski, Pier F. Cirillo, Yashang Lee
Publikováno v:
Biochemical Pharmacology. 86:222-230
The genus Mycobacterium includes non-pathogenic species such as M. smegmatis, and pathogenic species such as M. tuberculosis, the causative agent of tuberculosis (TB). Treatment of TB requires a lengthy regimen of several antibiotics, whose effective
Autor:
Pier F. Cirillo, Thomas J. Powell, Michel Ledizet, Lin Leng, Oluwatoyin A. Asojo, Fengwei Bai, Mihai Ciustea, Raymond A. Koski, Karen Anthony, Richard Bucala, Paul A. Aristoff
Publikováno v:
Journal of Biological Chemistry. 287:30653-30663
Macrophage migration inhibitory factor (MIF) is a catalytic cytokine and an upstream mediator of the inflammatory pathway. MIF has broad regulatory properties, dysregulation of which has been implicated in the pathology of multiple immunological dise
Autor:
Michael H. Cynamon, Adriana E. Rosato, Michel Ledizet, Mihai Ciustea, Sara Mootien, Oriana A. Perez, Raymond A. Koski, Paul Kaplan, Karen Anthony, Pier F. Cirillo, Paul A. Aristoff, Kacheong R. Yeung
Publikováno v:
Biochemical Pharmacology. 83:368-377
Methicillin-resistant Staphylococcus aureus (MRSA) is a human pathogen and a major cause of hospital-acquired infections. New antibacterial agents that have not been compromised by bacterial resistance are needed to treat MRSA-related infections. We