Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Raymond, Sweet"'
Autor:
Jinquan Luo, Juan Carlos Almagro, Galina Obmolova, Alexey Teplyakov, Thomas J. Malia, Salman Muzammil, Raymond Sweet, Gary L. Gilliland
Publikováno v:
mAbs
To support antibody therapeutic development, the crystal structures of a set of 16 germline variants composed of 4 different kappa light chains paired with 4 different heavy chains have been determined. All four heavy chains of the antigen-binding fr
Autor:
Xuesong Liu, Marc Vandermeeren, Raymond Sweet, Robin Ernst, Jinquan Luo, Thomas J. Malia, Marc Mercken, Alexey Teplyakov, Eilyn R. Lacy, Gary L. Gilliland, Sheng-Jiun Wu
Publikováno v:
Proteins
Microtubule‐associated protein tau becomes abnormally phosphorylated in Alzheimer's disease and other tauopathies and forms aggregates of paired helical filaments (PHF‐tau). AT8 is a PHF‐tau‐specific monoclonal antibody that is a commonly use
Autor:
Raymond Sweet, Gary L. Gilliland, Edward Keough, Alexey Teplyakov, Karyn O'neil, Randi Hippensteel, Galina Obmolova, Steven Jacobs, Fang Yi, Jinquan Luo, Thomas J. Malia
Publikováno v:
Proteins
The crystal structure of DARPin 44C12V5 that neutralizes IL‐4 signaling has been determined alone and bound to human IL‐4. A significant conformational change occurs in the IL‐4 upon DARPin binding. The DARPin binds to the face of IL‐4 formed
Protein crystallization with microseed matrix screening: application to human germline antibody Fabs
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The power of microseed matrix screening is demonstrated in the crystallization of a panel of antibody Fab fragments.
The crystallization of 16 human antibody Fab fragments constructed from all pairs of four different heavy chains and four differ
The crystallization of 16 human antibody Fab fragments constructed from all pairs of four different heavy chains and four differ
Autor:
Robyn L. Stanfield, Raymond Sweet, Galina Obmolova, Jinquan Luo, Juan Carlos Almagro, Thomas J. Malia, Alexey Teplyakov, Kodangattil Sreekumar R, Gary L. Gilliland
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 82:1563-1582
To assess the state-of-the-art in antibody structure modeling, a blinded study was conducted. Eleven unpublished Fab crystal structures were used as a benchmark to compare Fv models generated by seven structure prediction methodologies. In the first
Autor:
Tatiana Ort, Thomas J. Malia, Alexey Teplyakov, Gary L. Gilliland, Raymond Sweet, Deborah Kwok, Michael Scully, Nicole Wunderler, Linda Barone, Galina Obmolova
Publikováno v:
Molecular immunology. 83
CD27 is a T and B cell co-stimulatory protein of the TNF receptor superfamily dependent on the availability of the TNF-like ligand CD70. Two anti-CD27 neutralizing monoclonal antibodies were obtained from mouse hybridoma and subsequently humanized an
Autor:
Raymond Sweet, Galina Obmolova, Alexey Teplyakov, Thomas J. Malia, Tami L. R. Grygiel, Linda A. Snyder, Gary L. Gilliland
Publikováno v:
Molecular Immunology. 51:227-233
Human CC chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), is a member of the β chemokine family whose actions are mediated through the G-protein-coupled receptor CCR2. Binding of CCL2 to its receptor CCR2 triggers
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The application of microseed matrix screening to the crystallization of related antibodies in complex with IL-13 is described. Both self-seeding or cross-seeding helped promote nucleation and increase the hit rate.
The application of microseed m
The application of microseed m
Autor:
Eric Beil, Ken Dixon, Thomas J. Malia, Yonghong Zhao, Audrey Baker, Raymond Sweet, Gary L. Gilliland, Justin Sprenkle, Galina Obmolova, Sheng-Jiun Wu, Jinquan Luo, Bethany Swencki-Underwood, Alexey Teplyakov
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 77:1009-1014
Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as Hab18G, CD147, Basigin, M6, and neurothelin, is a membrane glycoprotein expressed on the surface of various cell types and many cancer cells. EMMPRIN stimulates adjacent fibrobla
Autor:
Marian Kruszynski, Nicole Stowell, Raymond Sweet, Ping Tsui, Jinquan Luo, George Heavner, Anuk Das, Jennifer F. Nemeth
Publikováno v:
Journal of Peptide Science. 12:354-360
Human monocyte chemoattractant protein 1 (MCP-1, CCL2) is a 8.6-kDa protein that has been implicated in a number of diseases including atherosclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease and cancer. As part of a program to id