Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Raymon Niemans"'
Autor:
Linda Spiegelberg, Ruud Houben, Raymon Niemans, Dirk de Ruysscher, Ala Yaromina, Jan Theys, Christopher P. Guise, Jeffrey B. Smaill, Adam V. Patterson, Philippe Lambin, Ludwig J. Dubois
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 15, Iss , Pp 62-69 (2019)
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II results, the
Externí odkaz:
https://doaj.org/article/75c6748e20a543519df6ae43fdf0f2f0
Autor:
Simon J A van Kuijk, Roben G Gieling, Raymon Niemans, Natasja G Lieuwes, Rianne Biemans, Brian A Telfer, Guido R M M Haenen, Ala Yaromina, Philippe Lambin, Ludwig J Dubois, Kaye J Williams
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161040 (2016)
Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherape
Externí odkaz:
https://doaj.org/article/ac88a352ecf64264b8874d1a5184899c
Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity
Autor:
Ludwig Dubois, Stefan J. van Hoof, Raymon Niemans, Frank Verhaegen, Jan Theys, R. Biemans, Ala Yaromina, Linda Spiegelberg, Natasja G. Lieuwes, Damiënne Marcus, Philippe Lambin
Publikováno v:
Radiotherapy and Oncology
Radiotherapy and Oncology, 141, 247-255. Elsevier Ireland Ltd
Radiotherapy and Oncology, 141, 247-255. Elsevier Ireland Ltd
Highlights • TH-302 combined with RT enhances tumor growth delay in esophageal cancer models. • This combination does not increase normal tissue toxicity on the short and long term. • The increased therapeutic index (1.38) paves the way for fut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb594bb8af9dae4c9990a0900c43b087
https://cris.maastrichtuniversity.nl/en/publications/d10c4418-7600-4deb-a569-fea7c45aab1b
https://cris.maastrichtuniversity.nl/en/publications/d10c4418-7600-4deb-a569-fea7c45aab1b
Autor:
Jeffrey Bruce Smaill, Raymon Niemans, Ala Yaromina, Philippe Lambin, Dirk De Ruysscher, Linda Spiegelberg, Adam V. Patterson, Ludwig Dubois, Jan Theys, Ruud Houben, Christopher P. Guise
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 15, Iss, Pp 62-69 (2019)
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, 15, 62-69. Elsevier Ireland Ltd
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, 15, 62-69. Elsevier Ireland Ltd
Highlights • Hypoxia-activated prodrugs have yielded promising results up to phase II trials. • Implementation of hypoxia-activated prodrugs in the clinic has not been successful. • Phase III clinical trials lack patient stratification based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dacf3137eb7d12771893eb800a6171
http://www.sciencedirect.com/science/article/pii/S2405630818301101
http://www.sciencedirect.com/science/article/pii/S2405630818301101
Autor:
Arthur Jochems, Jeff B. Smaill, Christopher P. Guise, Arne Heyerick, Maria R. Abbattista, Sophie Thiolloy, Amir Ashoorzadeh, Alexander M A van der Wiel, Kevin O. Hicks, Jan Theys, Ludwig Dubois, Philippe Lambin, Xiaojing Lin, Emily Liu, Robert F. Anderson, Zhe Fu, Damiënne Marcus, Victoria Jackson-Patel, Adam V. Patterson, Sisira Kumara, Ala Yaromina, Matthew Bull, Silvia Balbo, Morwena J. Solivio, R. Biemans, Sofie Deschoemaeker, Raymon Niemans, Alexandra M. Mowday, Natasja G. Lieuwes
Publikováno v:
Molecular Cancer Therapeutics, 20(12), 2372-2383. American Association for Cancer Research Inc.
Background Hypoxia-activated prodrugs (HAPs) are a promising class of antineoplastic agents that can selectively eliminate hypoxic tumor cells. The present study evaluates the hypoxia-selectivity and antitumor activity of CP-506, a DNA alkylating HAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da436b0cdc3474a21aab13146be81dd
https://pubmed.ncbi.nlm.nih.gov/34625504
https://pubmed.ncbi.nlm.nih.gov/34625504
Autor:
Matthew Bull, Maria R. Abbattista, Adam V. Patterson, Christopher Paul Guise, Ala Yaromina, Arne Heyerick, A. Mowday, Jeffrey Bruce Smaill, L.J. Dubois, Raymon Niemans, Amir Ashoorzadeh, Robert F. Anderson, Damiënne Marcus, A. Van der Wiel, P. Lambin, J. Theys
Publikováno v:
Radiotherapy and Oncology. 152:S313-S314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3901be359a883ff2c3a29ea370d90ba4
https://doi.org/10.1016/s0167-8140(21)00584-3
https://doi.org/10.1016/s0167-8140(21)00584-3
Autor:
Ivan Greguric, Ivo N. A. Pooters, Claudiu T. Supuran, Nigel A. Lengkeek, Sally-Ann Poulsen, Natasja G. Lieuwes, Ludwig Dubois, Kathryn F. Tonissen, Raymon Niemans, Deborah Sneddon, Paul A. Pellegrini, R. Biemans, Simon J. A. van Kuijk, Matthias Bauwens, Ala Yaromina, Philippe Lambin
Publikováno v:
Journal of Medicinal Chemistry, 59(13), 6431-6443. American Chemical Society
Tumor hypoxia contributes resistance to chemo- and radiotherapy, while oxygenated tumors are sensitive to these treatments. The indirect detection of hypoxic tumors is possible by targeting carbonic anhydrase IX (CA IX), an enzyme overexpressed in hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d5c3f8d853c57675872fb6141408fe
https://doi.org/10.1021/acs.jmedchem.6b00623
https://doi.org/10.1021/acs.jmedchem.6b00623
Autor:
Raymon Niemans
Hypoxia, i.e. low blood oxygen levels, is a common feature of solid tumours. Hypoxia causes tumour cells to become even more malignant. It is also associated with a poor prognosis and problems occurring during cancer treatment. This dissertation eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68060876ffc5fb4f553e855381534d6c
https://doi.org/10.26481/dis.20180626rn
https://doi.org/10.26481/dis.20180626rn
Autor:
P. Lambin, R. Biemans, Amir Ashoorzadeh, Arne Heyerick, Christopher Paul Guise, L.J. Dubois, Adam V. Patterson, Alexandra M. Mowday, Jeffrey Bruce Smaill, Raymon Niemans, Maria R. Abbattista, Sofie Deschoemaeker, Ala Yaromina, N. Lieuwes, Damiënne Marcus, Jan Theys
Publikováno v:
Radiotherapy and Oncology. 127:S1283-S1284
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab7b7f1bdfd6c45e75d78b704cff14eb
https://doi.org/10.1016/s0167-8140(18)32636-7
https://doi.org/10.1016/s0167-8140(18)32636-7
Autor:
Philippe Lambin, Ludwig Dubois, Ala Yaromina, Natasja G. Lieuwes, R. Biemans, Brian A. Telfer, Guido R.M.M. Haenen, Kaye J. Williams, Raymon Niemans, Simon J. A. van Kuijk, Roben G. Gieling
Publikováno v:
PLOS ONE, 11(8):e0161040. Public Library of Science
PLoS ONE, Vol 11, Iss 8, p e0161040 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161040 (2016)
PLoS ONE
Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0015a9f0028d8ab1a88076adbb66f6a8