Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry.

Autor: Rayani K; Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Davies B; Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Cheung M; Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Comber D; Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Roberts JD; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, ON, Canada., Tadros R; Cardiovascular Genetics Center, Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Universite de Montreal, Montreal, QC, Canada., Green MS; Heart Institute, University of Ottawa, Ottawa, ON, Canada., Healey JS; Population Health Research Institute, Hamilton, ON, Canada., Simpson CS; Department of Medicine, Queen's University, Kingston, ON, Canada., Sanatani S; Children's Heart Centre, BC Children's Hospital, Vancouver, BC, Canada., Steinberg C; Institut Universitaire de Cardiologie et Pneumologie de Quebec, Laval University, Quebec City, QC, Canada., MacIntyre C; Division of Cardiology, QEII Health Sciences Center, Halifax, NS, Canada., Angaran P; St Michael's Hospital, University of Toronto, Toronto, ON, Canada., Duff H; Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada., Hamilton R; Division of Cardiology, The Hospital for Sick Children (SickKids), Toronto, ON, Canada., Arbour L; Division of Medical Genetics, Island Health, Victoria, BC, Canada., Leather R; Royal Jubilee Hospital, Victoria, BC, Canada., Seifer C; Section of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada., Fournier A; Division of Pediatric Cardiology, CHU Sainte-Justine, Universite de Montreal, Montreal, QC, Canada., Atallah J; Division of Pediatric Cardiology, University of Alberta Stollery Children's Hospital, Edmonton, AB, Canada., Kimber S; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Makanjee B; Heart Health Institute, Scarborough Health Network, Scarborough, ON, Canada., Alqarawi W; Heart Institute, University of Ottawa, Ottawa, ON, Canada., Cadrin-Tourigny J; Cardiovascular Genetics Center, Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Universite de Montreal, Montreal, QC, Canada., Joza J; Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada., Gardner M; Division of Cardiology, QEII Health Sciences Center, Halifax, NS, Canada., Talajic M; Cardiovascular Genetics Center, Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Universite de Montreal, Montreal, QC, Canada., Bagnall RD; Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Krahn AD; Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Laksman ZWM; Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. zachary.laksman@ubc.ca.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2023 May; Vol. 31 (5), pp. 512-520. Date of Electronic Publication: 2022 Sep 22.

The effect of Mg ²⁺ on Ca ²⁺ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants.

Autor: Rayani K; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, Canada., Hantz ER; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA., Haji-Ghassemi O; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada., Li AY; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, Canada., Spuches AM; Department of Chemistry, 300 Science and Technology, East Carolina University, Greenville, NC, USA., Van Petegem F; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada., Solaro RJ; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, USA., Lindert S; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA., Tibbits GF; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada.

Publikováno v: The FEBS journal [FEBS J] 2022 Dec; Vol. 289 (23), pp. 7446-7465. Date of Electronic Publication: 2022 Aug 02.

Zebrafish as a model of mammalian cardiac function: Optically mapping the interplay of temperature and rate on voltage and calcium dynamics

Autor: Rayani, K, Lin, E, Craig, C, Lamothe, M, Shafaattalab, S, Gunawan, M, Li, AY, Hove-Madsen, L, Tibbits, GF

Publikováno v: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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The zebrafish (Danio rerio) heart is a viable model of mammalian cardiovascular function due to similarities in heart rate, ultrastructure, and action potential morphology. Zebrafish are able to tolerate a wide range of naturally occurring temperatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::2a62a00673af4142d818449b12c76903
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3309

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.

Autor: Ghovanloo MR; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC, Canada.; Science for Life Laboratory, Department of Physics, Royal Institute of Technology, Solna, Sweden., Choudhury K; Science for Life Laboratory, Department of Physics, Royal Institute of Technology, Solna, Sweden., Bandaru TS; Science for Life Laboratory, Department of Physics, Royal Institute of Technology, Solna, Sweden., Fouda MA; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.; Department of Pharmacology and Toxicology, Alexandria University, Alexandria, Egypt., Rayani K; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Rusinova R; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY., Phaterpekar T; Department of Molecular Biology and Biochemistry/Physics, Simon Fraser University, Burnaby, BC, Canada., Nelkenbrecher K; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC, Canada., Watkins AR; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Poburko D; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Thewalt J; Department of Molecular Biology and Biochemistry/Physics, Simon Fraser University, Burnaby, BC, Canada., Andersen OS; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY., Delemotte L; Science for Life Laboratory, Department of Physics, Royal Institute of Technology, Solna, Sweden., Goodchild SJ; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC, Canada., Ruben PC; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2021 May 03; Vol. 153 (5).

Binding of calcium and magnesium to human cardiac troponin C.

Autor: Rayani K; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, British Columbia, Canada., Seffernick J; Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA., Li AY; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada., Davis JP; Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA., Spuches AM; Department of Chemistry, East Carolina University, 300 Science and Technology Building, Greenville, North Carolina, USA., Van Petegem F; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada., Solaro RJ; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA., Lindert S; Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA., Tibbits GF; Molecular Cardiac Physiology Group, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada; Cardiac Group, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Electronic address: tibbits@sfu.ca.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100350. Date of Electronic Publication: 2021 Feb 03.