Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes

Autor: Fatemeh Moadab, Sepideh Sohrabi, Xiaoxing Wang, Rayan Najjar, Justina C. Wolters, Hua Jiang, Wenyan Miao, Donna Romero, Dennis M. Zaller, Megan Tran, Alison Bays, Martin S. Taylor, Rosana Kapeller, John LaCava, Tomas Mustelin

Publikováno v: Mobile DNA, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating with more stable disease. SLE is characterized by broad immune activation and autoantibodies ag

Externí odkaz: https://doaj.org/article/fe6226e258ca424d9883469888357136

Prediction of alternative pre-mRNA splicing outcomes

Autor: Rayan Najjar, Tomas Mustelin

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract To understand the biological impact of alternative pre-mRNA splicing, it is vital to know which exons are involved, what protein domains they encode, and how the translated isoforms differ. Therefore, we developed a computational pipeline (R

Externí odkaz: https://doaj.org/article/e2d1e491b4ab4f5eb5ea0156f700e16a

Non‐English Language Preference Associated With Decreased Rheumatology Telehealth Use During the COVID‐19 Pandemic

Autor: Jenna Thomason, Alison Bays, Bryanna Mantilla, Irvin Huang, Rayan Najjar, Namrata Singh, Katherine Wysham, Grant Hughes

Publikováno v: ACR Open Rheumatology, Vol 4, Iss 5, Pp 385-394 (2022)

Objective The study objective was to assess sociodemographic disparities in telehealth use among patients in an urban adult rheumatology clinic during the coronavirus disease 2019 (COVID‐19) pandemic. Methods In this retrospective cohort study, pat

Externí odkaz: https://doaj.org/article/3ce155ed70814db2a9a5fffa699accf3

Expression of Envelope Protein Encoded by Endogenous Retrovirus K102 in Rheumatoid Arthritis Neutrophils

Autor: Amanda Laine, Xiaoxing Wang, Kathryn Ni, Sarah E. B. Smith, Rayan Najjar, Leanne S. Whitmore, Michael Yacoub, Alison Bays, Michael Gale, Tomas Mustelin

Publikováno v: Microorganisms, Vol 11, Iss 5, p 1310 (2023)

Many patients suffering from autoimmune diseases have autoantibodies against proteins encoded by genomic retroelements, suggesting that normal epigenetic silencing is insufficient to prevent the production of the encoded proteins for which immune tol

Externí odkaz: https://doaj.org/article/352ff31df8624e8a8791342210f63991

Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain.

Autor: Rayan NA; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore, 138672, Singapore., Aow J; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore, 138672, Singapore.; NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lim MGL; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore, 138672, Singapore., Arcego DM; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Ryan R; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Nourbakhsh N; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore, 138672, Singapore., de Lima RMS; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Craig K; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Zhang TY; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Goh YT; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore, 138672, Singapore., Sun AX; Duke-NUS Graduate Medical School, Signature Research Program in Neuroscience and Behavioural Disorders, 8 College Road, Singapore, 169857, Singapore., Tompkins T; Lallemand Bio-Ingredients, 1620 Rue Prefontaine, Montréal, QC, H1W 2N8, Canada., Bronner S; Lallemand Health Solutions, Rosell Institute for Microbiome and Probiotics, 6100 Avenue Royalmount, Montréal, QC, H4P 2R2, Canada., Binda S; Lallemand Health Solutions, Rosell Institute for Microbiome and Probiotics, 6100 Avenue Royalmount, Montréal, QC, H4P 2R2, Canada., Diorio J; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Parent C; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada., Meaney MJ; NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. michael.meaney@mcgill.ca.; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, QC, H4H 1R3, Canada. michael.meaney@mcgill.ca.; Singapore Institute for Clinical Sciences, A*STAR, Singapore, 117609, Singapore. michael.meaney@mcgill.ca.; Brain-Body Initiative, Institute for Cell & Molecular Biology, A*STAR, Singapore, Singapore. michael.meaney@mcgill.ca., Prabhakar S; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore, 138672, Singapore. prabhakars@gis.a-star.edu.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore. prabhakars@gis.a-star.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. prabhakars@gis.a-star.edu.sg.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2024 Nov; Vol. 29 (11), pp. 3653-3668. Date of Electronic Publication: 2024 Jun 06.