Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Raya Eilam"'
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models
Autor:
Ilaria Marrocco, Donatella Romaniello, Itay Vaknin, Diana Drago‐Garcia, Roni Oren, Mary Luz Uribe, Nishanth Belugali Nataraj, Soma Ghosh, Raya Eilam, Tomer‐Meir Salame, Moshit Lindzen, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Some antibacterial therapies entail sequential treatments with different antibiotics, but whether this approach is optimal for anti‐cancer tyrosine kinase inhibitors (TKIs) remains open. EGFR mutations identify lung cancer patients who can
Externí odkaz:
https://doaj.org/article/f40e6d84396d426eb6294535a2d589ba
Autor:
Ron Hadas, Eran Gershon, Aviad Cohen, Ofir Atrakchi, Shlomi Lazar, Ofra Golani, Bareket Dassa, Michal Elbaz, Gadi Cohen, Raya Eilam, Nava Dekel, Michal Neeman
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Successful implantation is associated with a unique spatial pattern of vascular remodeling, characterized by profound peripheral neovascularization surrounding a periembryo avascular niche. We hypothesized that hyaluronan controls the formation of th
Externí odkaz:
https://doaj.org/article/ca89c7389330469687f57f5bfe731197
Autor:
Shaul Lerner, Elmira Anderzhanova, Sima Verbitsky, Raya Eilam, Yael Kuperman, Michael Tsoory, Yuri Kuznetsov, Alexander Brandis, Tevie Mehlman, Ram Mazkereth, Robert McCarter, Menahem Segal, Sandesh C.S. Nagamani, Alon Chen, Ayelet Erez, Fabienne Dietrich Alber, Talin Babikian, Heidi Bender, Christopher Boys, David Breiger, Corinna Buerger, Peter Burgard, Mina Nguyen-Driver, Benjamin Goodlett, Elizabeth Kerr, Casey Krueger, Eva Mamak, Jacqueline H. Sanz, David Schwartz, Susan Caudle, Arianna Stefanos, Rachel Tangen, Magdalena Walter, Susan Waisbren, Greta Wilkening
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2144-2153.e7 (2019)
Summary: Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the cen
Externí odkaz:
https://doaj.org/article/976ff388391d44aba3c02d09b832485b
Autor:
Adi Sagiv, Amir Bar-Shai, Naama Levi, Miki Hatzav, Lior Zada, Yossi Ovadya, Lior Roitman, Gal Manella, Ofer Regev, Julia Majewska, Ezra Vadai, Raya Eilam, Sara W. Feigelson, Michael Tsoory, Michel Tauc, Ronen Alon, Valery Krizhanovsky
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3468-3479 (2018)
Summary: The tumor suppressor p53 limits tumorigenesis by inducing apoptosis, cell cycle arrest, and senescence. Although p53 is known to limit inflammation during tumor development, its role in regulating chronic lung inflammation is less well under
Externí odkaz:
https://doaj.org/article/3f1c19548e7f4fcf87e7ad6139d3663b
Autor:
Maicol Mancini, Hilah Gal, Nadège Gaborit, Luigi Mazzeo, Donatella Romaniello, Tomer Meir Salame, Moshit Lindzen, Georg Mahlknecht, Yehoshua Enuka, Dominick GA Burton, Lee Roth, Ashish Noronha, Ilaria Marrocco, Dan Adreka, Raya Eilam Altstadter, Emilie Bousquet, Julian Downward, Antonio Maraver, Valery Krizhanovsky, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 294-308 (2018)
Abstract Epidermal growth factor receptor (EGFR) mutations identify patients with lung cancer who derive benefit from kinase inhibitors. However, most patients eventually develop resistance, primarily due to the T790M second‐site mutation. Irrevers
Externí odkaz:
https://doaj.org/article/29209c6b4c714c0b85c5ff5816ce736b
Autor:
Rina Aharoni, Raya Eilam, Shaul Lerner, Efrat Shavit-Stein, Amir Dori, Joab Chapman, Ruth Arnon
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13419 (2021)
Axonal and neuronal pathologies are a central constituent of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), induced by the myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. In this study, we in
Externí odkaz:
https://doaj.org/article/a02eb4baca554e88871e90e91370be8d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5904 (2021)
In multiple sclerosis (MS), astrocytes respond to the inflammatory stimulation with an early robust process of morphological, transcriptional, biochemical, and functional remodeling. Recent studies utilizing novel technologies in samples from MS pati
Externí odkaz:
https://doaj.org/article/144e1a38ee5c49949499eef0f54da45f
Autor:
Donatella Romaniello, Ilaria Marrocco, Nishanth Belugali Nataraj, Irene Ferrer, Diana Drago-Garcia, Itay Vaknin, Roni Oren, Moshit Lindzen, Soma Ghosh, Matthew Kreitman, Jeanette Clarissa Kittel, Nadege Gaborit, Gretchen Bergado Baez, Belinda Sanchez, Raya Eilam, Eli Pikarsky, Luis Paz-Ares, Yosef Yarden
Publikováno v:
Cancers, Vol 12, Iss 9, p 2394 (2020)
Although two growth factor receptors, EGFR and HER2, are amongst the best targets for cancer treatment, no agents targeting HER3, their kinase-defective family member, have so far been approved. Because emergence of resistance of lung tumors to EGFR
Externí odkaz:
https://doaj.org/article/11675062ac2d451c8ec22e88b30f6136
Autor:
Hadas Cohen‐Dvashi, Nir Ben‐Chetrit, Roslin Russell, Silvia Carvalho, Mattia Lauriola, Sophia Nisani, Maicol Mancini, Nishanth Nataraj, Merav Kedmi, Lee Roth, Wolfgang Köstler, Amit Zeisel, Assif Yitzhaky, Jacques Zylberg, Gabi Tarcic, Raya Eilam, Yoav Wigelman, Rainer Will, Sara Lavi, Ziv Porat, Stefan Wiemann, Sara Ricardo, Fernando Schmitt, Carlos Caldas, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 299-314 (2015)
Abstract Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we identify Navigator‐3 (NAV3), a gene frequently mutated or deleted in human tumors, as a regulator of epithelial migration and invasion. Following i
Externí odkaz:
https://doaj.org/article/8bb330c162f842b8ac6599b923fe4cb2
Publikováno v:
eLife, Vol 5 (2016)
Cortical blood flow can be modulated by local activity across a range of species; from barrel-specific blood flow in the rodent somatosensory cortex to the human cortex, where BOLD-fMRI reveals numerous functional borders. However, it appears that th
Externí odkaz:
https://doaj.org/article/c8dc6c36230943098112f746237cd80e