Výsledky vyhledávání - "Ray Valencia"

First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy

Autor: Jennifer R. Diamond, Valentina Boni, Emerson Lim, Grzegorz Nowakowski, Raul Cordoba, Daniel Morillo, Ray Valencia, Isabelle Genvresse, Claudia Merz, Oliver Boix, Melanie M. Frigault, Joy M. Greer, Ahmed M. Hamdy, Xin Huang, Raquel Izumi, Harvey Wong, Victor Moreno

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 28(7)

Purpose: To report on the first-in-human phase I study of VIP152 (NCT02635672), a potent and highly selective cyclin-dependent kinase 9 (CDK9) inhibitor. Patients and Methods: Adults with solid tumors or aggressive non–Hodgkin lymphoma who were ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582d063ddff9137ec0209cc07474e6d1
https://pubmed.ncbi.nlm.nih.gov/35046056

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Using electronic health records to derive a synthetic control arm for a historical trial on relapsed/refractory multiple myeloma

Autor: Alessandra Bisquera, Jamie Wallis, Ray Valencia, David Ruau, Nicholas Scott-Ram, Lewis Carpenter

Publikováno v: Journal of Clinical Oncology. 40:e20025-e20025

e20025 Background: It is increasingly challenging and ethically questionable to recruit patients on control arms when a vast body of information is readily available through electronic health records (EHR). Synthetic Control Arms (SCA) may reduce the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f15676c3f8e9d5d99571c73a939b4bd9
https://doi.org/10.1200/jco.2022.40.16_suppl.e20025

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Parametric Binding Images of the TSPO Ligand F-18-DPA-714

Autor: Robert C. Schuit, Jonas Eriksson, Merja Haaparanta-Solin, Bart N.M. van Berckel, Juha O. Rinne, Ray Valencia, Nina Savisto, Andrea Thiele, Pauliina Luoto, Jere Virta, Olof Solin, Adriaan A. Lammertsma, Anja Hoffmann, Geert Jan Groeneveld, Albert D. Windhorst, Erik T. te Beek, Ronald Boellaard, Sandeep S.V. Golla, Vesa Oikonen

Publikováno v: Golla, S S V, Boellaard, R, Oikonen, V, Hoffmann, A, van Berckel, B N M, Windhorst, A D, Virta, J, te Beek, E T, Groeneveld, G J, Haaparanta-Solin, M, Luoto, P, Savisto, N, Solin, O, Valencia, R, Thiele, A, Eriksson, J, Schuit, R C, Lammertsma, A A & Rinne, J O 2016, ' Parametric Binding Images of the TSPO Ligand F-18-DPA-714 ', Journal of Nuclear Medicine, vol. 57, no. 10, pp. 1543-1547 . https://doi.org/10.2967/jnumed.116.173013
Journal of Nuclear Medicine, 57(10), 1543-1547. Society of Nuclear Medicine Inc.

Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide (18F-DPA-714) is a radioligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e3aa3b5aa870179529d7ab98ed51db
https://doi.org/10.2967/jnumed.116.173013

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Phase I Study of the PTEFb Inhibitor BAY 1251152 in Patients with Acute Myelogenous Leukemia

Autor: Daniel Morillo, Martin Wermke, Mark G. Frattini, Raul Cordoba, Ioannis Mantzaris, Oliver G. Ottmann, Daniel J. Lee, Michael Byrne, Arne Scholz, Fabricio Souza, Stuart Ince, Ray Valencia

Publikováno v: Blood. 132:4055-4055

Introduction: The critical role of cyclin-dependent kinases in cell division and gene transcription has made them targets for anti-cancer therapies. Positive transcription elongation factor b (PTEFb)/cyclin-dependent kinase 9 (CDK9) plays a key role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8d0f8de614492401cfccae837f9886d
https://doi.org/10.1182/blood-2018-99-117257

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Phase I dose escalation study of the first-in-class selective PTEFb inhibitor BAY 1251152 in patients with advanced cancer: Novel target validation and early evidence of clinical activity

Autor: Claudia Merz, John Lettieri, Ray Valencia, Victor Moreno, Raul Cordoba, Valentina Boni, Jennifer R. Diamond, Emerson A. Lim, Stuart Ince, Charles Cai

Publikováno v: Journal of Clinical Oncology. 36:2507-2507

2507Background: PTEFb/CDK9 mediated transcription of short-lived anti-apoptotic survival proteins and oncogenes like MYC and MCL-1 plays a critical role in a variety of cancers. We present findings...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbfab51377abf27ac0af7b99a45bfb6f
https://doi.org/10.1200/jco.2018.36.15_suppl.2507

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Dosimetry and first clinical evaluation of the new 18F-radiolabeled bombesin analogue BAY 864367 in patients with prostate cancer

Autor: Linjing Mu, Thomas F. Hany, Ludger Dinkelborg, Sandra Borkowski, Keith Graham, Claudia Bacher-Stier, Niklaus Schaefer, Peter J. Wild, Ananth Srinivasan, Roger Schibli, Bert-Ram Sah, Irene A. Burger, Ray Valencia, Matthias Friebe

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 56(3)

372 Objectives To evaluate a noninvasive whole-body parametric image generation technique with high resolution PET-CT. Methods Patlak plot and a linear regression with spatial constraint (LRSC) algorithm was used to generate parametric images of FDG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3a7880f83606232fadd7fc4d62b44d
https://pubmed.ncbi.nlm.nih.gov/25678494

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