Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ray Pillai"'
Autor:
Anastasia-Maria Zavitsanou, Ray Pillai, Yuan Hao, Warren L. Wu, Eric Bartnicki, Triantafyllia Karakousi, Sahith Rajalingam, Alberto Herrera, Angeliki Karatza, Ali Rashidfarrokhi, Sabrina Solis, Metamia Ciampricotti, Anna H. Yeaton, Ellie Ivanova, Corrin A. Wohlhieter, Terkild B. Buus, Makiko Hayashi, Burcu Karadal-Ferrena, Harvey I. Pass, John T. Poirier, Charles M. Rudin, Kwok-Kin Wong, Andre L. Moreira, Kamal M. Khanna, Aristotelis Tsirigos, Thales Papagiannakopoulos, Sergei B. Koralov
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113295- (2023)
Summary: Lung cancer treatment has benefited greatly through advancements in immunotherapies. However, immunotherapy often fails in patients with specific mutations like KEAP1, which are frequently found in lung adenocarcinoma. We established an anti
Externí odkaz:
https://doaj.org/article/240bdf74cb4547dea3fb1640afd7bcf5
Autor:
Leopoldo N. Segal, Thales Papagiannakopoulos, Kwok-Kin Wong, Richard Bonneau, Huilin Li, Jose C. Clemente, Harvey I. Pass, Daniel H. Sterman, William N. Rom, Adriana Heguy, Aristotelis Tsirigos, William Moore, Andre L. Moreira, Cynthia A. Loomis, Valeria Mezzano, Sergei B. Koralov, Anastasia-Maria Zavitsanou, Ray Pillai, Kevin Felner, Harald Sauthoff, Robert L. Smith, Jamie L. Bessich, Samaan Rafeq, Gaetane Michaud, Linchen He, Nan Shen, James T. Morton, Michelle Badri, Mariam El-Ashmawy, Tadasu Iizumi, Joseph Carpenito, Brendan Franca, Luisannay Perez, Evan Olsen, Peter Meyn, Ting-An Yie, Yonghua Li, Rosemary Schluger, Katherine Gershner, Imran Sulaiman, Benjamin G. Wu, Jun-Chieh J. Tsay
Supplementary Figure 1-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45084f004644904ab2ad94b1c40f082a
https://doi.org/10.1158/2159-8290.22535168
https://doi.org/10.1158/2159-8290.22535168
Autor:
Leopoldo N. Segal, Thales Papagiannakopoulos, Kwok-Kin Wong, Richard Bonneau, Huilin Li, Jose C. Clemente, Harvey I. Pass, Daniel H. Sterman, William N. Rom, Adriana Heguy, Aristotelis Tsirigos, William Moore, Andre L. Moreira, Cynthia A. Loomis, Valeria Mezzano, Sergei B. Koralov, Anastasia-Maria Zavitsanou, Ray Pillai, Kevin Felner, Harald Sauthoff, Robert L. Smith, Jamie L. Bessich, Samaan Rafeq, Gaetane Michaud, Linchen He, Nan Shen, James T. Morton, Michelle Badri, Mariam El-Ashmawy, Tadasu Iizumi, Joseph Carpenito, Brendan Franca, Luisannay Perez, Evan Olsen, Peter Meyn, Ting-An Yie, Yonghua Li, Rosemary Schluger, Katherine Gershner, Imran Sulaiman, Benjamin G. Wu, Jun-Chieh J. Tsay
In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs, and ex vivo models support that some of these bacteria can trigger host transcriptomic signatures associated with carcinogenesis. Here, we show that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4661dacabf76498f52c10e3d10efe956
https://doi.org/10.1158/2159-8290.c.6547772.v1
https://doi.org/10.1158/2159-8290.c.6547772.v1
Autor:
Leopoldo N. Segal, Thales Papagiannakopoulos, Kwok-Kin Wong, Richard Bonneau, Huilin Li, Jose C. Clemente, Harvey I. Pass, Daniel H. Sterman, William N. Rom, Adriana Heguy, Aristotelis Tsirigos, William Moore, Andre L. Moreira, Cynthia A. Loomis, Valeria Mezzano, Sergei B. Koralov, Anastasia-Maria Zavitsanou, Ray Pillai, Kevin Felner, Harald Sauthoff, Robert L. Smith, Jamie L. Bessich, Samaan Rafeq, Gaetane Michaud, Linchen He, Nan Shen, James T. Morton, Michelle Badri, Mariam El-Ashmawy, Tadasu Iizumi, Joseph Carpenito, Brendan Franca, Luisannay Perez, Evan Olsen, Peter Meyn, Ting-An Yie, Yonghua Li, Rosemary Schluger, Katherine Gershner, Imran Sulaiman, Benjamin G. Wu, Jun-Chieh J. Tsay
Supplementary File Table 1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ec0cdbe1fcc5c0d7d0a974f6ab8fd
https://doi.org/10.1158/2159-8290.22535165.v1
https://doi.org/10.1158/2159-8290.22535165.v1
Autor:
Leopoldo N. Segal, Thales Papagiannakopoulos, Kwok-Kin Wong, Richard Bonneau, Huilin Li, Jose C. Clemente, Harvey I. Pass, Daniel H. Sterman, William N. Rom, Adriana Heguy, Aristotelis Tsirigos, William Moore, Andre L. Moreira, Cynthia A. Loomis, Valeria Mezzano, Sergei B. Koralov, Anastasia-Maria Zavitsanou, Ray Pillai, Kevin Felner, Harald Sauthoff, Robert L. Smith, Jamie L. Bessich, Samaan Rafeq, Gaetane Michaud, Linchen He, Nan Shen, James T. Morton, Michelle Badri, Mariam El-Ashmawy, Tadasu Iizumi, Joseph Carpenito, Brendan Franca, Luisannay Perez, Evan Olsen, Peter Meyn, Ting-An Yie, Yonghua Li, Rosemary Schluger, Katherine Gershner, Imran Sulaiman, Benjamin G. Wu, Jun-Chieh J. Tsay
Supplementary Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4d3bab28bde65ec906d8c7d1902d7d
https://doi.org/10.1158/2159-8290.22535162
https://doi.org/10.1158/2159-8290.22535162
Autor:
Ray Pillai, Sarah LeBoeuf, Ali Rashidfarrokhi, Shih Ming Huang, Triantafyllia Karakousi, Anastasia-Maria Zavitsanou, Warren Wu, Volkan Sayin, Robert Wild, Sergei Koralov, Thales Papagiannakopoulos
Publikováno v:
Cancer Research. 83:4904-4904
KEAP1 is mutated in approximately 20% of non-small cell lung cancer (NSCLC) and is associated with poor response rates to checkpoint blockade. Given the therapeutic challenge presented by KEAP1 mutant tumors and the great potential held by immunother
Publikováno v:
Cancer Discov
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf59c368ffb5282e9b93bc794bb5154
https://europepmc.org/articles/PMC8904278/
https://europepmc.org/articles/PMC8904278/
Autor:
Hongyu Ding, Katherine Wu, Sarah E. LeBoeuf, Warren L. Wu, Shih Ming Huang, Thales Papagiannakopoulos, Ray Pillai, Zihong Chen, Joshua D. Rabinowitz
Publikováno v:
Science Advances
Description
In Nrf2-activated tumors, G6pd inhibition depletes TCA intermediates and suppresses tumor growth.
The KEAP1/NRF2 pathway promotes metabolic rewiring to support redox homeostasis. Activation of NRF2 occurs in many cancers, often
In Nrf2-activated tumors, G6pd inhibition depletes TCA intermediates and suppresses tumor growth.
The KEAP1/NRF2 pathway promotes metabolic rewiring to support redox homeostasis. Activation of NRF2 occurs in many cancers, often
Autor:
Imran Sulaiman, Ray Pillai, Leopoldo N. Segal, Yi Li, J. Carpenito, Jun-Chieh J. Tsay, Benjamin G. Wu
Publikováno v:
TP94. TP094 DISCOVERIES IN BACTERIAL AND VIRAL PNEUMONIA PATHOGENESIS.
Autor:
Sarah LeBoeuf, Ray Pillai, Shih Ming Huang, Triantafyllia Karakousi, Warren Wu, Volkan Sayin, Robert Wild, Thales Papagiannakopoulos
Publikováno v:
Cancer Research. 82:2174-2174
Treating KRAS mutant lung adenocarcinoma (LUAD) remains a major challenge for clinical oncology. Approximately 20% of KRASmutant LUAD tumors carry loss-of-function mutations in KEAP1, a negative regulator of NRF2, which is the master transcriptional