Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Ray Luo"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6201 (2024)
SHP2, a pivotal component downstream of both receptor and non-receptor tyrosine kinases, has been underscored in the progression of various human cancers and neurodevelopmental disorders. Allosteric inhibitors have been proposed to regulate its autoi
Externí odkaz:
https://doaj.org/article/cc9c4386ca904787bdd28d09c2f8f85a
Autor:
Edward King, Sarah Maxel, Yulai Zhang, Karissa C. Kenney, Youtian Cui, Emma Luu, Justin B. Siegel, Gregory A. Weiss, Ray Luo, Han Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Engineering enzymes to accept noncanonical cofactor biomimetics is difficult. Here, the authors establish a self-sufficient growth selection method and demonstrate its application in engineering the Lactobacillus pentosus NADH oxidase to efficiently
Externí odkaz:
https://doaj.org/article/41cd426163c543aaa20d2d073663935b
Autor:
Linyue Zhang, Edward King, William B. Black, Christian M. Heckmann, Allison Wolder, Youtian Cui, Francis Nicklen, Justin B. Siegel, Ray Luo, Caroline E. Paul, Han Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Engineering enzymes to utilize the noncanonical redox cofactors such as nicotinamide mononucleotide (NMN + ) is challenging. Here, the authors report a growth-based selection platform for NMN + -reducing enzyme engineering and show its application in
Externí odkaz:
https://doaj.org/article/75d6e8408c81418bb081b0cb20fbd5ad
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0287465 (2023)
According to WHO 2019, Hepatocellular carcinoma (HCC) is the fourth highest cause of cancer death worldwide. More precise diagnostic models are needed to enhance early HCC and cirrhosis quick diagnosis, treatment, and survival. Breath biomarkers know
Externí odkaz:
https://doaj.org/article/565339e4eb0a4ef6893f519ccbb23933
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8310 (2023)
Living cells are extremely complicated systems and composed of hundreds of thousands of diverse biomolecules, such as proteins, nucleic acids, and carbohydrates [...]
Externí odkaz:
https://doaj.org/article/90a1f4923d2a41668ce39214bbb5a015
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The grand challenge in structure-based drug design is achieving accurate prediction of binding free energies. Molecular dynamics (MD) simulations enable modeling of conformational changes critical to the binding process, leading to calculation of the
Externí odkaz:
https://doaj.org/article/2d57e19c0f43462492e0d19ae18cb8d3
Autor:
Ray Luo, Akira Uematsu, Adam Weitemier, Luca Aquili, Jenny Koivumaa, Thomas J. McHugh, Joshua P. Johansen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Fear memories are overcome only when it is ascertained that fearful responses are not appropriate. Here the authors demonstrate that activity in dopamine neurons is necessary to extinguish fear responses and two distinct dopamine neuron projections e
Externí odkaz:
https://doaj.org/article/ab9559fb1bd242d5b4772bf9b61f7537
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7562 (2020)
Polyketides are a large class of structurally and functionally diverse natural products with important bioactivities. Many polyketides are synthesized by reducing type II polyketide synthases (PKSs), containing transiently interacting standalone enzy
Externí odkaz:
https://doaj.org/article/d22810cd64d447c1ac0a974df077ec7a
Publikováno v:
Catalysts, Vol 10, Iss 8, p 935 (2020)
Cyclohexanone monooxygenase (CHMO) from Acinetobacter sp. NCIMB 9871 is characterized as having wide substrate versatility for the biooxidation of (cyclic) ketones into esters and lactones with high stereospecificity. Despite industrial potential, CH
Externí odkaz:
https://doaj.org/article/113808512cf04055a7bb4e8fdd65d9de
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2018)
The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been widely applied as an efficient and reliable free energy simulation method to model molecular recognition, such as for protein-ligand binding interactions. In this revie
Externí odkaz:
https://doaj.org/article/b20434ef92aa4ef28370f99683978855