Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ray C. Bartolo"'
SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia
Autor:
Lauren M. Brown, Soroor Hediyeh-zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J. Sandow, Ray C. Bartolo, Hansen J. Kosasih, Nadia M. Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew I. Webb, Seong L. Khaw, Alicia Oshlack, Melissa J. Davis, Paul G. Ekert
Publikováno v:
Blood advances. 6(7)
Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expression profile resembling Philadelphia chromosome–positive ALL (Ph+ ALL) in the absence of BCR-ABL1. Tyrosine kinase–a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b322d3db730c9959c4cf2b501e4fa1ff
https://pubmed.ncbi.nlm.nih.gov/35061886
https://pubmed.ncbi.nlm.nih.gov/35061886
Autor:
Francoise Mechinaud, Lauren M Brown, Jackie Challis, Seong Lin Khaw, Dong-Anh Khuong-Quang, Ian Brooks, Breon Schmidt, Vida Petrovic, Paul G Ekert, Ray C Bartolo, Ian J. Majewski, Nadia M Davidson, Alicia Oshlack
Publikováno v:
Pediatric bloodcancerREFERENCES. 66(10)
We report two patients with leukaemia driven by the rare CNTRL-FGFR1 fusion oncogene. This fusion arises from a t(8;9)(p12;q33) translocation, and is a rare driver of biphenotypic leukaemia in children. We used RNA sequencing to report novel features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f042e23ed47de8d6d108b3e0338b0204
https://pubmed.ncbi.nlm.nih.gov/31250523
https://pubmed.ncbi.nlm.nih.gov/31250523
Autor:
Alicia Oshlack, Belinda Phipson, Lauren M Brown, L Morenos, Hansen J. Kosasih, Stefanie Eggers, Simon N. Willis, Paul G Ekert, L Zhou, Gregory J. Goodall, Gabriela Brumatti, Ray C Bartolo, N Narayan, Richard Saffery, Najoua Lalaoui, Daniel Catchpoole
Enforced expression of microRNA-155 (miR-155) in myeloid cells has been shown to have both oncogenic or tumour-suppressor functions in acute myeloid leukaemia (AML). We sought to resolve these contrasting effects of miR-155 overexpression using murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad78c945a90f390de55f593af8b2b4
https://hdl.handle.net/11541.2/126085
https://hdl.handle.net/11541.2/126085
Publikováno v:
Journal of Experimental Biology. 215:1218-1230
SUMMARYThe cystic fibrosis transmembrane conductance regulator (CFTR) is central to anion secretion in both the possum and eutherian small intestine. Here, we investigated its role in the possum proximal colon, which has novel transport properties co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7e2259c366c0474e020cdffa6eddc2
https://doi.org/10.1242/jeb.061176
https://doi.org/10.1242/jeb.061176
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences. 279:2599-2608
Like many desert animals, the spinifex hopping mouse, Notomys alexis , can maintain water balance without drinking water. The role of the kidney in producing a small volume of highly concentrated urine has been well-documented, but little is known ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e4237f1d846f998148d4a7ff7f4c0c
https://doi.org/10.1098/rspb.2011.2627
https://doi.org/10.1098/rspb.2011.2627
Publikováno v:
Journal of Experimental Biology. 212:2645-2655
Fluid secretion is essential for intestinal function and, in eutherian mammals, is driven by electrogenic Cl(-) transport, which is dependent upon a bumetanide-sensitive, basolateral Na(+)/K(+)/2 Cl(-) cotransporter, NKCC1. However, ileal secretion i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83f9bb227c73db3cd948b5d6934151
https://doi.org/10.1242/jeb.028928
https://doi.org/10.1242/jeb.028928
Publikováno v:
Journal of Comparative Physiology B. 179:997-1010
The colon of the brushtail possum does not have an electrogenic secretory response. Given the functional significance of electrogenic Cl(-) secretion in the intestine of eutherian mammals, we have investigated the secretory response in the small inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e34563d18cafba63f77520d7863c16
https://doi.org/10.1007/s00360-009-0379-8
https://doi.org/10.1007/s00360-009-0379-8
Autor:
Ray C. Bartolo, John A. Donald
Publikováno v:
Journal of Experimental Biology. 211:852-859
SUMMARYIn desert rodents, the production of concentrated urine is essential for survival in xeric environments in order to conserve water. Reabsorption of water in the kidney is dependent on large osmotic gradients in the renal medulla. This causes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17b583e1c2f0c3f2155be18f7afc59b
https://doi.org/10.1242/jeb.006395
https://doi.org/10.1242/jeb.006395
Autor:
John A. Donald, Ray C. Bartolo
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 148:853-860
Hyaluronan (HA) is a glycosaminoglycan that is synthesized by a family of enzymes called hyaluronan synthases (HASs), of which there are three isoforms (HAS1, 2 and 3) in mammals. The HASs have different tissue expression patterns and function, indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca78f4f29e296eb6eb35892f28acc98c
https://doi.org/10.1016/j.cbpa.2007.08.027
https://doi.org/10.1016/j.cbpa.2007.08.027
Publikováno v:
General and Comparative Endocrinology. 148:181-186
C-type natriuretic peptide (CNP) is a crucial osmoregulatory hormone in elasmobranchs, participating in salt secretion and drinking. In contrast to teleosts and tetrapods in which the NP family is composed of a group of structurally related peptides,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8f533a5aa957808daaf4279b573437
https://doi.org/10.1016/j.ygcen.2006.02.014
https://doi.org/10.1016/j.ygcen.2006.02.014