Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis

Autor: Xianhui Ruan, Wei Yan, Minghui Cao, Ray Anthony M. Daza, Miranda Y. Fong, Kaifu Yang, Jun Wu, Xuxiang Liu, Melanie Palomares, Xiwei Wu, Arthur Li, Yuan Chen, Rahul Jandial, Nicholas C. Spitzer, Robert F. Hevner, Shizhen Emily Wang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Breast cancer metastasis to the brain is a clinical challenge rising in prevalence. However, the underlying mechanisms, especially how cancer cells adapt a distant brain niche to facilitate colonization, remain poorly understood. A unique me

Externí odkaz: https://doaj.org/article/5c970c2a746849fab76890be4746d396

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia

Autor: Ehsan Ghayoor Karimiani, Laura E. Kuil, Tjakko J. van Ham, Irene J. Chang, Robert F. Hevner, Reza Maroofian, C. Dirk Keene, Dana M. Jensen, Lee Astle, Caitlin S. Latimer, Herma C. van der Linde, Giridhar M. Shivaram, Nynke Oosterhof, Jeroen Demmers, Erica Young, Emily Loter, Ray A. M. Daza, James T. Bennett

Publikováno v: American Journal of Human Genetics, 104(5), 936-947. Cell Press
American Journal of Human Genetics, 936-947. CELL PRESS
STARTPAGE=936;ENDPAGE=947;ISSN=0002-9297;TITLE=American Journal of Human Genetics

Microglia are CNS-resident macrophages that scavenge debris and regulate immune responses. Proliferation and development of macrophages, including microglia, requires Colony Stimulating Factor 1 Receptor (CSF1R), a gene previously associated with a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7691d605562e8ec60c91756d238346
https://research.rug.nl/en/publications/88cf7183-11a2-4b12-a5cf-8996726812b7

Unipolar (Dendritic) Brush Cells Are Morphologically Complex and Require Tbr2 for Differentiation and Migration

Autor: Ray A M Daza, Ashley McDonough, Olivia M DelleTorri, Amelia R Bachleda, Robert F. Hevner, Gina E. Elsen, Donald P. Pizzo

Publikováno v: Frontiers in Neuroscience, Vol 14 (2021)
Frontiers in Neuroscience

Previous studies demonstrated specific expression of transcription factor Tbr2 in unipolar brush cells (UBCs) of the cerebellum during development and adulthood. To further study UBCs and the role of Tbr2 in their development we examined UBC morpholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f835a26f92fce2319fbff6ace215525
https://www.frontiersin.org/articles/10.3389/fnins.2020.598548/full

Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis

Autor: Robert F. Hevner, Seungshin Ha, Ray A. M. Daza, David R. Beier, Prem Prakash Tripathi

Publikováno v: Journal of Developmental Biology
Volume 8
Issue 3
Journal of developmental biology, vol 8, iss 3
Journal of Developmental Biology, Vol 8, Iss 20, p 20 (2020)

We have previously described hypomorphic reelin (Reln) mutant mice, RelnCTRdel, in which the morphology of the dentate gyrus is distinct from that seen in reeler mice. In the RelnCTRdel mutant, the infrapyramidal blade of the dentate gyrus fails to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fde39c2e5953ea10a0c4a3baa0d150
https://doi.org/10.1101/543074

Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity

Autor: Francesco Bedogni, Anca B. Mihalas, Robert F. Hevner, Sebastian J. Arnold, Gina E. Elsen, Ray A. M. Daza, Kevyn A. Ramos-Laguna

Publikováno v: Cell Reports, Vol 16, Iss 1, Pp 92-105 (2016)

SummaryIntermediate progenitors (IPs) amplify the production of pyramidal neurons, but their role in selective genesis of cortical layers or neuronal subtypes remains unclear. Using genetic lineage tracing in mice, we find that IPs destined to produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e326ed40d794bca0bcc1e621c0ef753
http://www.sciencedirect.com/science/article/pii/S2211124716306854