FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

Autor: Rawshan Choudhury, Nadhim Bayatti, Richard Scharff, Ewa Szula, Viranga Tilakaratna, Maja Søberg Udsen, Selina McHarg, Janet A. Askari, Martin J. Humphries, Paul N. Bishop, Simon J. Clark

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract Retinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch�

Externí odkaz: https://doaj.org/article/744e5ccb41c64bcf9d0d0a1eaadb8a8c

Multiple Proteins of

Autor: Cecile, El-Chami, Rawshan, Choudhury, Walaa, Mohammedsaeed, Andrew J, McBain, Veera, Kainulainen, Sarah, Lebeer, Reetta, Satokari, Catherine A, O'Neill

Publikováno v: Frontiers in microbiology. 13

We have previously shown that lysates of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0da0a39bb8e52092da6375778bfffb9
https://pubmed.ncbi.nlm.nih.gov/35633665

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

Autor: Martin J. Humphries, Paul N. Bishop, Nadhim Bayatti, Maja Søberg Udsen, Rawshan Choudhury, Viranga Tilakaratna, Selina McHarg, Richard Scharff, Ewa Szula, Simon J. Clark, Janet A. Askari

Publikováno v: Scientific Reports
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M, Mcharg, S, Askari, J, Humphries, M J, Bishop, P & Clark, S 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, no. 1, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M S, McHarg, S, Askari, J A, Humphries, M J, Bishop, P N & Clark, S J 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Retinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch’s membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd44c6c515f5cf3e410767874f2acb8
https://pubmed.ncbi.nlm.nih.gov/34239032

Differential Clathrin Binding and Subcellular Localization of OCRL1 Splice Isoforms

Autor: Christopher J. Noakes, Martin Lowe, Corinne Kox, Edward A. McKenzie, Rawshan Choudhury

Publikováno v: Journal of Biological Chemistry. 284:9965-9973

Mutation of the inositol polyphosphate 5-phosphatase OCRL1 causes the X-linked disorder oculocerebrorenal syndrome of Lowe, characterized by defects in the brain, kidneys, and eyes. OCRL1 exists as two splice isoforms that differ by a single exon enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954e4a919b7d774a9130f9f8a3e9da49
https://doi.org/10.1074/jbc.m807442200

Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway

Autor: Catrin Williams, Rawshan Choudhury, Edward A. McKenzie, Martin Lowe

Publikováno v: Journal of cell science. 120(Pt 22)

The inositol polyphosphate 5-phosphatase INPP5B is closely related to the Lowe syndrome protein OCRL1, sharing a similar substrate specificity, domain organisation and an ability to compensate for loss of OCRL1 in knockout mice. The cellular localisa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d0251bf57a9bb074086408b8883baf
https://pubmed.ncbi.nlm.nih.gov/17956944