Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.

Autor: Sasmal PK; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India. Electronic address: pradipks@drreddys.com., Krishna CV; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Adabala SS; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Roshaiah M; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Rawoof KA; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Thadi E; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Sukumar KP; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Cheera S; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Abbineni C; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Rao KV; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Prasanthi A; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Nijhawan K; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Jaleel M; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Iyer LR; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Chaitanya TK; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Tiwari NK; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Krishna NL; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Potluri V; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Khanna I; Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India., Frimurer TM; 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark; NNF, Center for Protein Research and NNF Center for Basic Metabolic Research, University of Copenhagen, Denmark., Lückmann M; NNF, Center for Protein Research and NNF Center for Basic Metabolic Research, University of Copenhagen, Denmark., Rist Ø; 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark., Elster L; 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark., Högberg T; 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark. Electronic address: thomas.hogberg@leo-pharma.com.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 887-92. Date of Electronic Publication: 2015 Jan 06.

PROTACs: Current Trends in Protein Degradation by Proteolysis-Targeting Chimeras.

Autor: Madan J; Aurigene Discovery Technologies Limited, 39-40, KIADB Industrial Area, Electronic City, Phase-2, Bangalore, 560100, India., Ahuja VK; Aurigene Discovery Technologies Limited, 39-40, KIADB Industrial Area, Electronic City, Phase-2, Bangalore, 560100, India., Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia., Samajdar S; Aurigene Discovery Technologies Limited, 39-40, KIADB Industrial Area, Electronic City, Phase-2, Bangalore, 560100, India., Ramchandra M; Aurigene Discovery Technologies Limited, 39-40, KIADB Industrial Area, Electronic City, Phase-2, Bangalore, 560100, India., Giri S; Aurigene Discovery Technologies Limited, 39-40, KIADB Industrial Area, Electronic City, Phase-2, Bangalore, 560100, India. sanjeev_g@aurigene.com.

Publikováno v: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy [BioDrugs] 2022 Sep; Vol. 36 (5), pp. 609-623. Date of Electronic Publication: 2022 Sep 13.

Fluorine in Heterocyclic Chemistry Volume 1 : 5-Membered Heterocycles and Macrocycles

Autor: Valentine Nenajdenko

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second v