The AML1-ETO Fusion Gene and the FLT3 Length Mutation Collaborate in Inducing Acute Leukemia in a Murine Bone Marrow Transplantation Model

Autor: Scheßl, C, Rawat, VPS, Cusan, M, Deshpande, A, Kohl, TM, Rosten, PM, Spiekermann, K, Humphries, RK, Schnittger, S, Kern, W, Hiddemann, W, Quintanilla-Martinez, L

Publikováno v: 27. Deutscher Krebskongress; 20060322-20060326; Berlin; DOCOP103 /20060320/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1175::d2c525d4eb6375f60d03f08ddfdefc07
http://www.egms.de/en/meetings/dkk2006/06dkk213.shtml

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A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.

Autor: Bamezai S; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Pulikkottil AJ; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Yadav T; Department of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA., Vegi NM; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Mueller J; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Mark J; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Mandal T; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany.; Department of Oncology Pathology, Karolinska Institute, Stockholm, Sweden., Feder K; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Ihme S; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Song C; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany., Rosler R; Core Unit Mass Spectrometry and Proteomics, Faculty of Natural Science, Ulm University, Ulm, Germany., Wiese S; Core Unit Mass Spectrometry and Proteomics, Faculty of Natural Science, Ulm University, Ulm, Germany., Hoell JI; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Hematology and Oncology, Martin Luther University Halle-Wittenberg, Halle, Germany., Kloetgen A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany., Karsan A; Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada., Kumari A; Basepair Technology Inc, New York, NY., Wojenski L; Basepair Technology Inc, New York, NY., Sinha AU; Basepair Technology Inc, New York, NY., Gonzalez-Menendez I; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180), Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Quintanilla-Martinez L; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180), Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany., Donato E; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center and DKFZ-ZMBH Alliance, Heidelberg, Germany., Trumpp A; HI-STEM-Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center and DKFZ-ZMBH Alliance, Heidelberg, Germany., Kruse E; Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Munich, Germany., Hamperl S; Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Munich, Germany., Zou L; Department of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA., Rawat VPS; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany.; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India., Buske C; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany.

Publikováno v: Blood [Blood] 2023 Jul 06; Vol. 142 (1), pp. 90-105.

TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways.

Autor: Pulikkottil AJ; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Bamezai S; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Ammer T; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Mohr F; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Feder K; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Vegi NM; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Mandal T; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Kohlhofer U; Institute of Pathology, University Hospital Tübingen, Tübingen, Germany., Quintanilla-Martinez L; Institute of Pathology, University Hospital Tübingen, Tübingen, Germany., Sinha A; Basepair, New York, NY, USA., Buske C; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany. christian.buske@uni-ulm.de., Rawat VPS; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany. vijaypsrawat@mail.jnu.ac.in.; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. vijaypsrawat@mail.jnu.ac.in.

Publikováno v: Leukemia [Leukemia] 2022 Feb; Vol. 36 (2), pp. 416-425. Date of Electronic Publication: 2021 Aug 30.

TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.

Autor: Bamezai S; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Demir D; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Pulikkottil AJ; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Ciccarone F; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy., Fischbein E; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Sinha A; Basepair, New York, NY, USA., Borga C; Department of Women's and Children's Health, University of Padova, Padova, Italy., Te Kronnie G; Department of Women's and Children's Health, University of Padova, Padova, Italy., Meyer LH; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Mohr F; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Götze M; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Caiafa P; Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy., Debatin KM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Döhner K; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Döhner H; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., González-Menéndez I; Institute of Pathology, University of Tübingen, 72076, Tübingen, Germany., Quintanilla-Fend L; Institute of Pathology, University of Tübingen, 72076, Tübingen, Germany., Herold T; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.; German Consortium for Translational Cancer Research (DKTK), Partnering Site Munich, Munich, Germany., Feuring-Buske M; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany.; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Buske C; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany. christian.buske@uni-ulm.de., Rawat VPS; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany. vijay.rawat@uni-ulm.de.

Publikováno v: Leukemia [Leukemia] 2021 Feb; Vol. 35 (2), pp. 389-403. Date of Electronic Publication: 2020 May 15.