δ-Valerolactamic Quaternary Amino Acid Derivatives : Enantiodivergent Synthesis and Evidence for Stereodifferentiated β-Turn-Inducing Properties

Autor: Sandrine Py, Arnaud Martel, Sullivan Bricaud, Romain Ligny, Sopa Chewchanwuttiwong, Mathieu Y. Laurent, Rawan Hadade, Corentin Jacquemmoz, Jérôme Lhoste, Gilles Dujardin, X. M. Zhang

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2021, 86 (12), pp.8041-8055. ⟨10.1021/acs.joc.1c00456⟩

International audience; Enantiopure (R) and (S) cyclic α,α-disubstituted amino acid derivatives displaying a δ-valerolactam side chain were prepared from a common isoxazolidine precursor. The (R)-configured δ-valerolactam 11 was converted into di

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