Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Rawan, Shraim"'
Autor:
Guillem Pascual-Pasto, Brendan McIntyre, Margaret G. Hines, Anna M. Giudice, Laura Garcia-Gerique, Jennifer Hoffmann, Pamela Mishra, Stephanie Matlaga, Simona Lombardi, Rawan Shraim, Patrick M. Schürch, Mark Yarmarkovich, Ted J. Hofmann, Fatemeh Alikarami, Daniel Martinez, Matthew Tsang, Luis Gil-de-Gómez, Timothy T. Spear, Kathrin M. Bernt, Adam J. Wolpaw, Dimiter S. Dimitrov, Wei Li, Kristopher R. Bosse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive pediatric solid tumor that expresses cell-surface GPC2 and GD2 with a tumor microenv
Externí odkaz:
https://doaj.org/article/b2ad4e5f753a46548b7df6730192b457
Autor:
Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz:
https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
Autor:
Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2
Externí odkaz:
https://doaj.org/article/a888480056e0487995e0516acf1b06ce
Autor:
Paul M Sondel, Amy K Erbe, Daniel Martinez, Samantha N Buongervino, Kristopher R Bosse, Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Doncho V Zhelev, Shakhnozakhon Sadirova, Anna M Giudice, Laura Garcia-Gerique, Dimiter S Dimitrov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Antibody–drug conjugates (ADCs) that deliver cytotoxic drugs to tumor cells have emerged as an effective and safe anticancer therapy. ADCs may induce immunogenic cell death (ICD) to promote additional endogenous antitumor immune response
Externí odkaz:
https://doaj.org/article/01e319d8e2634ac2869c9e31926d7548
Autor:
Karen L. Bride, Hai Hu, Anastasia Tikhonova, Tori J. Fuller, Tiffaney L. Vincent, Rawan Shraim, Marilyn M. Li, William L. Carroll, Elizabeth A. Raetz, Iannis Aifantis, David T. Teachey
Publikováno v:
Haematologica, Vol 107, Iss 8 (2021)
Despite improvements in outcomes for children with B- and T-cell acute lymphoblastic leukemia (B-ALL and T-ALL), patients with resistant or relapsed disease fare poorly. Previous studies have demonstrated the essential role of cyclin D3 in T-ALL dise
Externí odkaz:
https://doaj.org/article/5de625346f4e411da1839face46afb2f
Autor:
Caroline Diorio, Rawan Shraim, Regina Myers, Edward M. Behrens, Scott Canna, Hamid Bassiri, Richard Aplenc, Chakkapong Burudpakdee, Fang Chen, Amanda M. DiNofia, Saar Gill, Vanessa Gonzalez, Michele P. Lambert, Allison Barz Leahy, Bruce L. Levine, Robert B. Lindell, Shannon L. Maude, J. Joseph Melenhorst, Haley Newman, Jessica Perazzelli, Alix E. Seif, Simon F. Lacey, Carl H. June, David M. Barrett, Stephan A. Grupp, David T. Teachey
Publikováno v:
Clinical Cancer Research. 28:3804-3813
Purpose: To study the biology and identify markers of severe cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment. Experimental Desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35fa230d856563f2e452186b3a0a53ac
https://doi.org/10.1158/1078-0432.ccr-22-0822
https://doi.org/10.1158/1078-0432.ccr-22-0822
Autor:
Andrei Thomas-Tikhonenko, Sarah K. Tasian, Yoseph Barash, Marco Ruella, Kristen W. Lynch, Nathan Singh, Maureen M. O'Brien, Susan R. Rheingold, Deanne M. Taylor, Rawan Shraim, Mukta Asnani, Carolin Schmidt, John Chukinas, Asen Bagashev, David A. Hottman, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Zhiwei Ang, Katharina E. Hayer, Ammar S. Naqvi, Elisabeth Gillespie, Sisi Zheng
Supplementary Data from Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab6aeb24bca7462aba4fb3d2d8eb381
https://doi.org/10.1158/2643-3230.22544534.v1
https://doi.org/10.1158/2643-3230.22544534.v1
Autor:
David T. Teachey, Stephan A. Grupp, David M. Barrett, Carl H. June, Simon F. Lacey, Alix E. Seif, Jessica Perazzelli, Haley Newman, J. Joseph Melenhorst, Shannon L. Maude, Robert B. Lindell, Bruce L. Levine, Allison Barz Leahy, Michele P. Lambert, Vanessa Gonzalez, Saar Gill, Amanda M. DiNofia, Fang Chen, Chakkapong Burudpakdee, Richard Aplenc, Hamid Bassiri, Scott Canna, Edward M. Behrens, Regina Myers, Rawan Shraim, Caroline Diorio
Supplementary Figure from Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ea37624a911897821d7d53eaf0e21b
https://doi.org/10.1158/1078-0432.22486239
https://doi.org/10.1158/1078-0432.22486239
Autor:
David T. Teachey, Stephan A. Grupp, David M. Barrett, Carl H. June, Simon F. Lacey, Alix E. Seif, Jessica Perazzelli, Haley Newman, J. Joseph Melenhorst, Shannon L. Maude, Robert B. Lindell, Bruce L. Levine, Allison Barz Leahy, Michele P. Lambert, Vanessa Gonzalez, Saar Gill, Amanda M. DiNofia, Fang Chen, Chakkapong Burudpakdee, Richard Aplenc, Hamid Bassiri, Scott Canna, Edward M. Behrens, Regina Myers, Rawan Shraim, Caroline Diorio
Purpose:To study the biology and identify markers of severe cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment.Experimental Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0ed49ad93e8dcfdff405cac8704407
https://doi.org/10.1158/1078-0432.c.6532275
https://doi.org/10.1158/1078-0432.c.6532275
Autor:
David T. Teachey, Stephan A. Grupp, David M. Barrett, Carl H. June, Simon F. Lacey, Alix E. Seif, Jessica Perazzelli, Haley Newman, J. Joseph Melenhorst, Shannon L. Maude, Robert B. Lindell, Bruce L. Levine, Allison Barz Leahy, Michele P. Lambert, Vanessa Gonzalez, Saar Gill, Amanda M. DiNofia, Fang Chen, Chakkapong Burudpakdee, Richard Aplenc, Hamid Bassiri, Scott Canna, Edward M. Behrens, Regina Myers, Rawan Shraim, Caroline Diorio
Supplementary Data from Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bf1b3153cfa9dbdf9e5f69f61e1b03
https://doi.org/10.1158/1078-0432.22486251
https://doi.org/10.1158/1078-0432.22486251