Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rawad Farhat"'
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 2, Pp n/a-n/a (2021)
Abstract Aim It has been suggested that repeated activation of the adrenergic system during antecedent episodes of hypoglycaemia contributes to the development of counterregulatory failure. We previously reported that treatment with carvedilol, a non
Externí odkaz:
https://doaj.org/article/dc0099b2817e42308ede83084b55b628
Autor:
Rawad Farhat, Julian Aiken, Ninoschka C. D'Souza, Daniel Appadurai, Grayson Hull, Eric Simonson, Richard T. Liggins, Michael C. Riddell, Owen Chan
Publikováno v:
Diabetes, obesitymetabolismREFERENCES. 24(5)
To evaluate the pharmacokinetics and efficacy of a novel somatostatin receptor 2 antagonist, ZT-01, to stimulate glucagon release in rats with type 1 diabetes (T1D).The pharmacokinetics of ZT-01 and PRL-2903 were assessed following intraperitoneal or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22553c402eb17fd95d966fb64cf4990f
https://pubmed.ncbi.nlm.nih.gov/35060297
https://pubmed.ncbi.nlm.nih.gov/35060297
Publikováno v:
Endocrinology, Diabetes & Metabolism
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 2, Pp n/a-n/a (2021)
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 2, Pp n/a-n/a (2021)
Aim It has been suggested that repeated activation of the adrenergic system during antecedent episodes of hypoglycaemia contributes to the development of counterregulatory failure. We previously reported that treatment with carvedilol, a non‐specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94d801f3a5421f7973458e0df31b448
https://doi.org/10.1002/edm2.226
https://doi.org/10.1002/edm2.226
Autor:
Anne-Sophie Sejling, Peili Wang, Daniel A. Appadurai, Owen Chan, Nicholas Knight, Wanling Zhu, Rawad Farhat
Publikováno v:
Endocrinology
Activation of the adrenergic system in response to hypoglycemia is important for proper recovery from low glucose levels. However, it has been suggested that repeated adrenergic stimulation may also contribute to counterregulatory failure, but the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c57871f6da1114da291890934e99d16
https://pubmed.ncbi.nlm.nih.gov/33367607
https://pubmed.ncbi.nlm.nih.gov/33367607
Autor:
Julian Aiken, Michael C. Riddell, Richard Liggins, Eric Simonson, Rawad Farhat, Owen Chan, Ninoschka C. D’Souza
Publikováno v:
Diabetes. 69
Iatrogenic hypoglycemia remains one of the most serious risks for people with type 1 diabetes (T1D) undergoing intensive insulin therapy. Development of counterregulatory failure, occurring in the early stages of diabetes, highlighted by loss of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4572e9e96aaba5f52a2080253ad38ae
https://doi.org/10.2337/db20-9-lb
https://doi.org/10.2337/db20-9-lb
Publikováno v:
Diabetes. 69
Restoration of the lost glucagon response to hypoglycemia may be an effective means to prevent the onset of hypoglycemia in patients with type 1 diabetes (T1D). Elevation of the inhibitory hormone somatostatin in T1D may act on alpha cells, via the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abfe2730b55645f7bc34ac2d86d94a99
https://doi.org/10.2337/db20-12-lb
https://doi.org/10.2337/db20-12-lb
Publikováno v:
Diabetes. 68
It has been suggested that repeated activation of the adrenergic system during antecedent episodes of hypoglycemia may contribute to the development of counterregulatory failure. We previously showed that treatment with the non-specific β-blocker, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4afa4f37ac95f293015f1ef60ea0acf
https://doi.org/10.2337/db19-117-or
https://doi.org/10.2337/db19-117-or
Publikováno v:
Diabetologia. 62(4)
AIMS/HYPOTHESIS: This study evaluates whether the non-selective β-blocker, carvedilol, can be used to prevent counterregulatory failure and the development of impaired awareness of hypoglycaemia (IAH) in recurrently hypoglycaemic rats. METHODS: Spra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a41f07144dde706aa7b284b5d8ddb5
https://pubmed.ncbi.nlm.nih.gov/30627753
https://pubmed.ncbi.nlm.nih.gov/30627753
Publikováno v:
Diabetes. 67
We showed previously that recurring activation of β2-adrenergic receptors in the ventromedial hypothalamus (VMH) leads to the development of counterregulatory failure, in part by increasing local lactate levels. The current study evaluates whether t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5ccc3dfe32b155c62d5e6eb2c578a13
https://doi.org/10.2337/db18-200-or
https://doi.org/10.2337/db18-200-or
Autor:
Haree K. Pallera, Pamela S. Hair, Parvathi S. Kumar, W. Thomas Bass, Frank A. Lattanzio, Tushar A. Shah, Jasmine E. Nejad, Rawad Farhat, Neel K. Krishna
Publikováno v:
Pediatric research. 81(4)
Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the multifactorial mechanisms by which HT impacts HIE are incompletely understood. The complement system plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952b32accc66807e639be37d12477a6d
https://pubmed.ncbi.nlm.nih.gov/28002390
https://pubmed.ncbi.nlm.nih.gov/28002390